Stanford University

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

DOSE: An open-source, iOS watch-based tool for experience sampling

Smartwatches facilitate low-burden rapid-access micro-interactions, making them ideal for Experience Sampling Methods (ESMs). Despite the Apple Watch being the most popular smartwatch in the U.S., it has yet to be utilized in ESM studies due to a lack of accessible frameworks tha...

Algebraic characterization of equivalence between oracle-based iterative algorithms

Abstract When are two algorithms the same? How can we be sure a recently proposed algorithm is novel, and not a minor variation on an existing method? In this paper, we present a framework for reasoning about equivalence between a broad class of iterative algorithms, with a focus...

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed outcomes for melanoma brain metastases (MBM), yet early response assessment remains challenging because currently available tools such as magnetic resonance imaging (MRI) lack molecular specificity and are confounded b...

Therapeutic selective leukotriene b4 antagonism for human lymphedema

Despite a high prevalence and extensive morbidity, there are no approved pharmacological interventions for lymphedema. Selective inhibition of leukotriene B 4 has been identified as a potential therapeutic target to address the morbidity and symptomatology associated with lymphed...

Peripheral blood transcriptomic signature is associated with cognitive impairment and freezing of gait in Parkinson’s disease: a data-driven approach

Abstract Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder with variable long-term outcomes. Blood-based biomarkers for prognostic prediction remain underdeveloped. We aimed to develop a peripheral blood transcriptomic signature for predicting long-term compl...

Early life exposures association with later diagnosis of spondyloarthritis: A population-based case-control study

Objective To assess whether early-life antibiotics are associated with spondyloarthritis (SpA) diagnosed by age 21. Methods In this population-based, matched case–control study, we used Danish live births (1997-2023) restricted to those reaching minimum relevant ages by December...

A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer

PURPOSE: Immune checkpoint inhibitors have limited activity as monotherapy in biliary cancers. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic immune cell growth factor which achieved prolonged survival when combined with ipilimumab in melanoma. We cond...

Tuning Viscoelasticity of Dynamic Covalent Hydrogels for Human Tissue Modeling

ABSTRACT The development of three‐dimensional (3D) in vitro tissue culture models is critical for biomedical research. Hydrogel‐based systems have become preferred scaffolds for 3D models, as they have tunable viscoelastic properties, which are well‐known to influence cell morpho...

Highly attenuated dendritic propagation of isolated synaptic potentials in vivo

The integration of synaptic inputs is a fundamental function of neurons. In the traditional model, excitatory inputs are summed at the soma to generate action potentials. However, how synaptic inputs are integrated by dendrites in vivo remains poorly explored. We used intravital...

Interfacial LithiumRedox Kinetics Regulated by SolventAsymmetry and Moment of Inertia in Li Metal Batteries

Abstract Lithium metal batteries (LMBs) offer high energy density, but interfacial charge-transfer kinetics remain a bottleneck for high-rate operation. In this work, we construct a library of 12 ether solvents with systematic variations in symmetry and fluorination, confirming t...

Aligning protein-generative models to experimental fitness with ProteinDPO

Abstract Biological generative models can predict biological functions without task-specific training data but often under-perform specialized models. This is due to a fundamental ‘alignment gap’, where the rules learned during unsupervised training are not related to the functio...

Drought dynamics explain once in a century yellow fever virus outbreak in Brazil with implications for climate change

While excess rainfall is associated with mosquito-borne disease because it supports mosquito breeding, drought may also counterintuitively increase disease transmission by altering mosquito and host behavior. This phenomenon is important to understand because climate change is pr...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

The choice-wide behavioral association study: data-driven identification of interpretable behavioral components

Behavior contains rich structure across many timescales, but there is a dearth of methods to identify relevant components, especially over the longer periods required for learning and decision-making. Inspired by the goals and techniques of genome-wide association studies, we pre...

Worked and Working Bones—Wild Resource Use in an Agricultural Neolithic Community at Miaodigou Site, China

This paper examines worked-bone production at the Miaodigou (MDG) site, a key Middle Neolithic settlement in northern China, to assess the role of bone objects in craft production, subsistence, and social life. During the expansion of millet agriculture and pig domestication, a s...

Synthesizing Colloidal Bimetallic Nanoparticles in Water Using a Dual‐Ligand Strategy

ABSTRACT Controlled aqueous synthesis of bimetallic nanoparticles below 5 nm remains challenging due to reduction potential mismatches between noble and base metals, which often causes uncontrolled aggregation. Here, we propose a dual‐ligand strategy to assist the commonly used s...

A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks

A century and a half of neuroscience has yielded many divergent theories of the neurobiology of language. Two factors that likely contribute to this situation include (a) conceptual disagreement about language and its component processes, and (b) intrinsic inter-individual variab...

Deep Learning‐Based Enhancement of Already Diagnostic‐Quality MRI for Alzheimer's Disease Classification: Effects on Model Performance and Training Data Requirements

ABSTRACT Background Deep learning (DL)‐based image enhancement is widely used to improve suboptimal medical imaging. Whether it also benefits diagnostic‐quality MRI in downstream task performance and data‐efficiency remains unclear. Purpose To investigate the impact of DL‐based e...