Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study
Abstract
This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC increased across successive birth cohorts in both high-income countries (HICs) and low- and middle-income countries (LMICs), with mean values rising steadily with later birth year. In fully adjusted models, FVC increased by 21.4 mL, FEV 1 by 24.6 mL and FEV 1 /FVC by 0.25% per birth year. These positive associations were consistent across sex, smoking status and country-income subgroups (HICs and LMICs).
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Authors: Jixuan Ma, Peter Burney, David Mannino, Christer Janson, Thorarinn Gislason, Daniel Obaseki, Rain Jögi, Valentina Quintero Santofimio, James Potts, Abdul Rashid, Gregory Erhabor, Rune Nielsen, Ali Kocabas, Asaad Nafees, Rana Ahmed, Meriam Denguezli, Cristina Barbara, João Cardoso, Hermínia Brites Dias, Fátima Rodrigues, Dr Dhiraj Agarwal, Sanjay Juvekar, Frits Franssen, Terence Seemungal, Kevin Mortimer, Mohammed El Biaze, Padukudru Mahesh, Parvaiz Koul, Michael Studnicka, Andre Amaral
Institutions: University of Iceland, University of British Columbia, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Imperial College London, University of Liverpool, Huazhong University of Science and Technology, Uppsala University, Obafemi Awolowo University, University of the West Indies, Instituto Politécnico de Lisboa, University of Lisbon, University of Kentucky, University of KwaZulu-Natal, Administração Regional de Saúde de Lisboa e Vale do Tejo, Cukurova University, Maastricht University Medical Centre, University of Monastir, Universidade Nova de Lisboa, University of Bergen, Aintree University Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Paracelsus Medical University, Centre de recherche en Epidémiologie et Santé des Populations, NIHR Imperial Biomedical Research Centre, Tartu University Hospital, University of Sousse, Reykjavík University, National University Hospital of Iceland, JSS Medical College and Hospital, Aga Khan University, Hospital de Santa Maria, Instituto de Saúde, Sher-i-Kashmir Institute of Medical Sciences, Unidade Local de Saúde de São José, RCSI & UCD Malaysia Campus, Agence pour le Développement et la Réhabilitation de la Ville de Fès