Imperial College London

Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy

An urgent requirement in chimeric antigen receptor (CAR) immune cell therapy [e.g., CAR–natural killer (NK) cells] for solid tumors is to engineer the cells for precise tumor targeting. Meanwhile, medical microrobots can be navigated toward specific target sites using external ma...

Aptamer-Based Fluorescent Assays for Detection of the Host-Response Viral Biomarker 3′-Deoxy-3′,4′-Didehydro-Cytidine

Abstract Improved viral diagnostics are urgently needed to strengthen pandemic preparedness and combat antimicrobial resistance, highlighting the importance of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC), a host-derived, pan-viral biomarker that addresses key limitations of PCR-base...

Particle systems and McKean–Vlasov dynamics with singular interaction through local times

We study a system of reflected Brownian motions on the positive half-line in which each particle has a drift toward the origin determined by the local times at the origin of all the particles. If this local time drift is too strong, such systems exhibit a breakdown in their solut...

Functional trait space overlaps reveal ecological resilience of bird communities in Atlantic Forest fragments

While fragmentation is known to affect species diversity, the degree to which functional structure is retained relative to primary forests and the factors driving this retention remain poorly understood. Here, we applied the concept of ecological resilience to forest fragmentatio...

A broad-host-range Rhizobium rhizogenes strain enables transient expression across diverse crop species

Agrobacterium -mediated transient expression has revolutionised plant research, enabling numerous landmark discoveries across diverse areas of plant biology. Yet this powerful approach remains largely confined to solanaceous species, leaving most economically important crop famil...

UK consensus recommendations for onward testing for Lynch syndrome in patients with deficient mismatch repair (dMMR) non-colorectal/non-endometrial cancers

Accepted: 2026) UK consensus recommendations for onward testing for Lynch Syndrome in patients

Recurrent neural chemical reaction networks trained to switch dynamical behaviours through learned bifurcations

Both natural and synthetic chemical systems not only exhibit a range of non-trivial dynamics, but also transition between qualitatively different dynamical behaviours as environmental parameters change. Such transitions are called bifurcations. Here, we show that recurrent neural...

Quantitative CT in the real-world evaluation of progressive pulmonary fibrosis; the REVISE PPF multicentre observational study

Abstract Rationale and Objective We assessed whether an FDA-cleared quantitative CT (qCT) tool (Brainomix, e-Lung) identifies progressive pulmonary fibrosis (PPF) earlier than routine clinical diagnosis and evaluated the prognostic value of baseline and serial imaging biomarkers....

Frequency of plastic occurrence varies across phylogeny but not ecology in seabirds

Seabirds are especially vulnerable to ingesting plastic pollution. However, we have a limited understanding of which traits might increase their risk of plastic ingestion. Here, we use a dataset of seabird plastic occurrence records (93 281 birds from 240 species) to investigate...

Hypertension detection, treatment and control in young adults in Australia

Young adult hypertension increases risk of future cardiovascular disease but is often overlooked. We aimed to identify opportunities to reduce blood pressure among younger adults by determining the drivers of hypertension detection, treatment and control in young adults in Austra...

A 15-year evaluation of two total knee arthroplasty designs

Aims: To compare 15-year patient-reported outcomes measure (PROMs), pain characteristics, implant survivorship, and radiological findings between two total knee arthroplasty (TKA) systems to determine whether modern implant design influenced outcomes. Methods: A minimum 15-year f...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Producing a Red List of Ecosystems for the Brazilian Cerrado

Abstract Land clearance is a key driver of biodiversity loss. This is a particular challenge in the Brazilian Cerrado, the world's most biodiverse savanna biome and a region experiencing a rapid expansion of agriculture. To inform habitat conservation and restoration actions, we...

Growth trajectory and miscarriage diagnosis threshold in early IVF pregnancy: multicenter study

ABSTRACT Objectives To characterize early‐pregnancy ultrasound findings in pregnancies conceived via in‐vitro fertilization (IVF) for which gestational age is known precisely based on the date of embryo transfer (ET), and to examine their association with first‐trimester pregnanc...

Impact and sustainability of master trainer-led obstetric emergency skills training in Uganda: a qualitative study

BACKGROUND: Maternal mortality remains a major challenge in Uganda, where the maternal mortality ratio is 189 per 100,000 births - fifty time higher than in the UK. The Royal College of Obstetricians and Gynaecologists' Excellence in Obstetric Skills (EOS) and Resilience in Obste...

Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8⁺ T-cell clonal dominance in head and neck cancer

Abstract Concomitant chemoradiotherapy (CRT) is a standard-of-care treatment for unresectable locally advanced head and neck squamous cell carcinoma (LA-SCCHN), but its immune effects, particularly relative to radiotherapy (RT) alone, remain incompletely understood. Using syngene...

The Importance of Nanoscale Phenomena in Electrolyte Behavior: Acetonitrile-Aqueous Zinc Sulfate Electrolytes

Abstract Electrolytes composed of mixed solvents are of significant scientific and technological importance in lithium-ion and beyond-lithium-ion batteries, and more broadly across physical chemistry. Their emergence has highlighted the importance of multiscale phenomena, particu...

Integrating Ion Mobility-Resolved Tandem Mass Spectrometry and Microcrystal Electron Diffraction for Structural Elucidation

Abstract Determining the three-dimensional structures of small molecules in complex mixtures remains challenging as current approaches typically require physical isolation and quantities of material that are excessive for many components. Here we present a reciprocal structure-de...

Parallel-in-Time Preconditioning for Time-Dependent Variational Mean Field Games

Abstract We study the numerical approximation of a time-dependent variational mean field game system with local couplings and either periodic or Neumann boundary conditions. Following a variational approach, we employ a finite-difference discretization and solve the resulting fin...

SERINC5 is the primary target of retroviral antagonists among human SERINC paralogs and requires a tri-cysteine motif for its counteraction by HIV-1 Nef

The human transmembrane protein SERINC5 incorporates into budding HIV-1 particles and inhibits virus fusion with target cells. Although three other human SERINC paralogs display antiviral activity, their contribution to retroviral restriction and their susceptibility to viral ant...