Imperial College London

Shaping light in 3D for direct asymmetric photochemistry: a 1000-fold enantioselectivity enhancement

Abstract Shaping electronic motion with tailored light enables unprecedented control over matter: from realising topological states in quantum materials to steering chemical reactions along specific pathways. Yet, despite the vital roles of molecular chirality across nature, stan...

Nanoparticle accumulation in the lymph node is impaired in aged mice

Abstract Vaccine responses are impaired in aged mice and older people. A key first step in mounting successful responses to vaccines is for antigens to access the draining lymph node from the site of injection. Here we tested the hypothesis that nanoparticle drainage to the lymph...

Quantifying the Photoelectrochemically Active Surface Area for Oxygen Evolution Metal Oxide Photoelectrocatalysts

Abstract Nanostructuring is established as a photoelectrode performance enhancing route for solar-driven catalytic processes. However, it is often unclear to what extent the increase in photoelectrode physical surface area directly results in a commensurate increase in photoelect...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

Data-Driven Aerodynamic Kernel Functions for Boundary Element Flow Models

A method for predicting aerodynamic flows using learned kernel functions for the underlying boundary element problem is introduced. A formulation for the baseline potential flow kernels is presented, followed by the methodology of learning the kernel from a computational fluid dy...

Few-shot neuromorphic vision in a nonlinear photonic network laser

With the growing prevalence of artificial intelligence (AI), demand increases for hardware that mimics the brain’s ability to extract structure from limited data. In the retina, ganglion cells detect features from sparse inputs via lateral inhibition, where neurons antagonistical...

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a major therapeutic target in type 2 diabetes and obesity. Missense variation in GIPR could confer phenotypic effects through alterations to constitutive activity or functional responses to GIP or pharmacological...

Decomposition of wastewater sources in England

Abstract The flow arriving at a wastewater treatment plant mixes municipal sewage, rainfall, soil moisture and groundwater, yet is routinely interpreted as if its composition were fixed. Despite the uncertainty this introduces to any case where the signal is used, from combined s...

Six weeks of isometric resistance training led to evidence of corticospinal but not reticulospinal adaptation in previously untrained adult males

Abstract The latest hypothesis regarding the source of enhanced neural activation from resistance training is the reticulospinal rather than the corticospinal tract, based on invasive animal and emerging human data. The present study employed a six-week isometric resistance train...

Formalizing Multi-graded Brenner–Schröer Proj Schemes and Dilatations of Rings in Lean4

Abstract We present a formalization in Lean4 of some multi-graded algebraic geometry constructions, focusing on the Brenner–Schröer Proj construction and algebraic dilatations of rings. Multi-graded Proj schemes, defined from rings graded by more general monoids than $$\mathbb {N...

Phase Transitions for Interacting Particle Systems on Random Graphs

Abstract. In this paper, we study weakly interacting diffusion processes on random graphs. Our main focus is on the properties of the mean-field limit and, in particular, on the nonuniqueness and bifurcation structure of stationary states. By extending classical bifurcation analy...

Techno–economic optimisation of hydrogen geological storage in UK depleted gas reservoirs

Long-duration energy storage is becoming critical in the UK to manage renewable intermittency, prolonged low-generation periods, and energy curtailment. Depleted natural gas reservoirs offer a promising option for large-scale underground hydrogen storage because of their substant...

Autoimmune-associated thrombosis: mechanisms, population burden, and prevention strategies

Autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, and systemic vasculitis, are associated with increased risk of thrombosis, accelerated atherosclerosis, cardiovascular-events, and premature mortality. Heparin-induced th...

Primary care quality and secondary healthcare utilisation in patients with multimorbidity: a retrospective cohort study

Background High-quality primary care can improve multimorbidity management but little evidence is available to understand its impact on secondary care use over time. Aim To assess the concurrent and lagged associations between quality of primary care and planned and unplanned sec...

Overall and serotype-specific dengue virus transmission intensity in Mexico, 2016–2023: A modelling study of case-notification data

Background Mexico, and the Americas region more widely, have experienced increased dengue incidence in recent years, and there are concerns that the changing climate may enhance dengue virus (DENV) transmission in the future. Whilst previous studies have characterised spatial het...

Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure

Abstract Introduction Perianal pouch fistula can significantly affect quality of life, yet no disease-specific patient reported outcome measure (PROM) exists. We have developed and validated a 14-item PROM—the Pouch Anal and Vaginal Fistula Quality of Life scale (PAVF-QoL-14). Me...

Applying a systemic approach that extends beyond the brain to Alzheimer’s disease pathogenesis

Traditional dementia research often isolates single aspects, biomarkers or symptoms, overlooking complex interactions shaping disease risk and progression. Lysosomal and mitochondrial dysfunction, reflecting systemic processes, may explain links between Alzheimer’s and metabolic,...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

OligoSeq: Rapid nanopore-sequencing of single-stranded oligonucleotides

Nanopore-based DNA sequencing technology has achieved remarkable success in sequencing increasingly long DNA strands (e.g. over a million nucleotides long) for genomics research and biotechnology applications. However, the same level of progress has not been achieved for DNA olig...

Population genomics, resistome and plasmidome of invasive Klebsiella pneumoniae isolates in adults hospitalised in Johannesburg, South Africa

Abstract Klebsiella pneumoniae (KPn) is a leading cause of healthcare-associated infections in adults in low- and middle-income countries. We conducted laboratory-based surveillance between 2023 and 2024 in Johannesburg, South Africa, and analysed 508 KPn whole genomes isolated f...