Tartu University Hospital

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

CT-based radiological score (AMESI CT-score) for severity of bowel injury in acute mesenteric ischemia

PURPOSE: To evaluate whether common bowel-related CT signs alone can reliably identify irreversible bowel injury in acute mesenteric ischemia (AMI) and to develop a radiological score to enhance reporting and assist clinical decision-making. METHODS: This ancillary analysis of th...

Delivery mode and maternal health conditions before and after childbirth: A population‐based cohort study from Estonia

INTRODUCTION: Cesarean section (CS) is the most common gynecological surgery globally, with rates increasing in many developed countries. In Estonia, the CS rate rose from 6.4% in 1992 to 20.6% in 2021. While CS can be lifesaving when medically necessary, its rising use without c...

Initial diagnosis of extraparatoid Warthin’s tumor in a 64-year-old Syrian patient: a challenging diagnosis

Warthin tumor (WT) is the second most prevalent benign neoplasm of the salivary glands. WT is mainly detected near the mandibular angle in the parotid gland, accounting for 2–15% of parotid gland neoplasms. Extraparotid presentations, on the other hand, occur in less than 1% of c...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Comprehensive NMR metabolomic profiling reveals a pro-atherogenic signature in psoriasis

Abstract Psoriasis (PS) is a chronic inflammatory skin disease associated with cardiometabolic comorbidity. While systemic inflammation is recognized as a major driver of this risk, metabolomic signatures linking PS to cardiometabolic dysfunction remain incompletely defined. The...