Dr. D. Y. Patil Medical College, Hospital and Research Centre

Blistered by Benzodiazepines: A Rare Case of Lorazepam-induced Bullous Drug Reaction

Abstract Lorazepam is routinely prescribed for managing alcohol withdrawal. It is particularly useful in patients with liver disease. However, lorazepam can cause side effects, such as sedation, respiratory depression, and ataxia, but cutaneous side effects are rare. A 40-year-ol...

Mapping Research Trends and Future Research Directions in Robo-advisory: A Structural Topic Modelling Approach

Robo-advisory services have revolutionized the investment landscape by leveraging advanced technology to provide automated and personalized investment guidance to investors. We explore key research themes addressed in the literature on robo-advisory and identify research avenues...

Metabolic syndrome prevalence clinical profile and associated metabolic risk factors among women with polycystic ovary syndrome in a tertiary care setting

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting women of reproductive age and is associated with insulin resistance, dyslipidemia, obesity, and an increased risk of metabolic syndrome (MetS). Early identification of metabolic abnormalities...

Laparoscopic Total Hysterectomy with Bilateral Salpingectomy in a Perimenopausal Woman with Chronic Cervicitis and Pelvic Adhesions

Abstract Chronic cervicitis is a common gynecological condition that may present with persistent vaginal discharge and pelvic discomfort. When conservative management fails, surgical intervention may be warranted. We report the case of a 42-year-old perimenopausal woman with chro...

Correlation of Serological Status with Disease Activity Score 28-Erythrocyte Sedimentation Rate Score in Elderly Patients with Rheumatoid Arthritis: A Cross-sectional Study

Abstract Background: Rheumatoid arthritis (RA) in the elderly is a clinically distinct entity with unique presenting features, serological profiles, and high disease burden. Elderly-onset RA (EORA), defined as RA with onset at or after 65 years, remains understudied in the Indian...

Emerging Biomarkers Across the Clinical Spectrum of SARS-CoV-2 Infection and Long COVID

Long COVID, also referred to in the literature as postacute sequelae of SARS-CoV-2 infection (PASC) or postacute COVID-19 syndrome (PACS), is a chronic and heterogeneous multisystem condition persisting beyond acute COVID-19. For consistency, this review uses the term “Long COVID...

Zirconium Dioxide Nanoparticles in Bone Tissue Engineering: Recent Advances, Biological Interactions, and Future Perspectives

Bone defects from trauma, tumor resection, infection, and degenerative disease remain a large clinical problem, and the grafting strategies used to treat them still carry familiar limitations: donor-site morbidity for autografts, variable integration and supply constraints for al...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

Parental Stress in the Pediatric Intensive Care Unit and Its Association with Clinical Outcomes: A Prospective Observational Study

Abstract Background: Children, who represent the emotional center of parents and the future of the nation, when hospitalized in the pediatric intensive care unit (PICU), place caregivers under substantial psychological strain due to disruption of family life and persistent uncert...

Emerging materials and technologies for next-generation sensors in smart IoT systems: a comprehensive review

As the Internet of Things (IoT) continues to advance at an unprecedented rate, there is a growing need for intelligent, adaptable, low-power and sustainable sensing platforms that can operate autonomously over long periods. This paper examines the technological advances in IoT se...

Enhancing blepharoplasty outcomes with a novel floor bite technique

Blepharoplasty is a commonly performed esthetic and functional eyelid surgery. However, post-operative complications such as hematoma formation and wound dehiscence can compromise surgical outcomes. This article presents a novel modification – placing a floor bite during wound cl...

Thymidine kinase 1 is elevated in prostate cancer and correlates with tumor aggressiveness: a systematic review and meta-analysis

Non-invasive biomarkers can inform prostate cancer diagnosis, surgical decision-making, and treatment. However, early screening biomarkers, including prostate-specific antigen (PSA), lack specificity due to elevation in benign conditions. Thymidine kinase 1 (TK1), a DNA synthesis...

Experimental and numerical investigation of voltage-dependent active vibration control on a notch-cracked composite mono leaf spring

This paper presents combined experimental and numerical research on the application of an Active Vibration Control System (AVCS) to a cracked glass-fibre-reinforced polymer (GFRP) composite mono leaf spring for automotive suspension systems, an application that, to the authors’ k...

Volatility-adaptive temporal learning framework using hybrid ARIMA-QuadGRU attention for multi-regime financial forecasting

Abstract Conventional financial market forecasting models are challenged by the non-stationarity, the existence of regime changes, the presence of structural breaks, and the phenomena of volatility clustering in financial markets. Linear approaches have only limited accuracy in t...

Chronic Retained Products of Conception Masked by Müllerian Duct Anomaly: The Diagnostic Value of Hysteroscopy

ABSTRACT: Müllerian duct anomalies are congenital uterine malformations that may present with pelvic pain, menstrual irregularities, or infertility. However, acquired intrauterine pathologies can occasionally mimic congenital anomalies on imaging, leading to diagnostic confusion....

Antitubercular evaluation and synthesis of fused pyrano-thiazole-2-one derivatives via green and efficient protocol

Tuberculosis has become one of the leading causes of mortality worldwide. In developing countries, tuberculosis is one of the 10th leading causes of death, highlighting the urgent need for antitubercular drugs. In this study, we synthesized fused pyrano-thiazole-2-one derivatives...

Resilience and Disparity: A statistical reevaluation of the pandemic-era self-harm crisis using Global Burden of Disease data (1990–2023)

Background Early models projected pandemic-driven increases in suicide and violence. This study utilizes Global Burden of Disease (GBD) 2023 data to evaluate mortality trajectories for self-harm and interpersonal violence (1990-2023), assessing regional and demographic pandemic-e...

Case report on Vitamin B6-Responsive Gyrate atrophy with Cystoid Macular Edema in a Consanguineous Young Male: A Treatable Metabolic Retinopathy

Abstract Gyrate atrophy is a rare autosomal recessive chorioretinal dystrophy caused by ornithine aminotransferase deficiency, resulting in toxic accumulation of plasma ornithine and progressive retinal degeneration. We describe a 20-year-old male, born to consanguineous parents,...

Two Forgotten Ipsilateral Double J Stents Managed in a Single Session: A Rare Endourologic Challenge

ABSTRACT: Forgotten ureteral stents may lead to severe complications such as encrustation, infection, obstruction, and stone formation, especially when retained beyond 12 weeks. Dual forgotten stents in the same renal system managed in a single operative session are rare. A 51-ye...

Coinfection of Two Endemics – Scrub Typhus and Malaria

ABSTRACT: Malaria and scrub typhus are both significant causes of acute febrile illness in the Indian subcontinent. Due to their overlapping clinical manifestations, it can be a challenge to distinguish between the two. Coinfection, although rarely seen, may lead to greater disea...