University of Kentucky

Prophylactic Negative Pressure Wound Therapy Versus Standard Wound Care Among Lower Extremity Amputations: A Meta-Analysis

Prophylactic closed incisional negative pressure wound therapy (NPWT) has emerged as a promising strategy to reduce postoperative wound complications following lower extremity amputation in patients with peripheral arterial disease (PAD). We conducted a meta-analysis to evaluate...

Hatching plasticity and embryonic learning in chorus frog ( Pseudacris triseriata ) embryos in response to predatory burrowing crayfish ( Lacunicambarus chimera )

Crayfish represent a profound threat to amphibian populations worldwide, often acting as keystone predators that disrupt breeding success and contribute to local declines. In particular, voracious predation on eggs can consume substantial proportions of clutches, exacerbating vul...

A traffic safety resilience assessment incorporating conflict risk: application and comparison on two open roads with lateral interferences

Lateral interferences on open roads cause conflicts and delays that dissipate at varying rates, implying that open roads have different risk-absorption capacities. This study develops a traffic safety resilience (TSR) framework combining crossing time-to-collision (CTTC) with tim...

Co-opted CHIP E3 Ub-ligase provides protein quality control by regulating molecular properties of condensates formed by a positive-strand RNA virus

Positive-strand RNA viruses are important pathogens that built viral replication organelles (VROs) via exploiting co-opted host proteins and intracellular membranes in infected cells. Tomato bushy stunt virus (TBSV) membranous VROs are associated with dynamic virus-induced replic...

Transcutaneous spinal cord stimulation for functional recovery in individuals with hereditary spastic paraplegia: Protocol for a pilot clinical trial

Background Hereditary spastic paraplegia (HSP) is a rare genetic neurodegenerative disorder characterized by progressive lower-extremity spasticity, weakness, and gait impairment resulting from corticospinal tract degeneration. With no disease-modifying therapies available, novel...

Pediatric Mental Health Screening Practices Across Health Systems: A Multistate Survey

Despite an ongoing youth mental health crisis, mental health screening practices by pediatric health systems are unknown. The aim of the current study is to describe mental health screening practices in pediatric health systems and identify potential targets for improvement. Pedi...

Distributed Delay Stabilizes Bistable Genetic Networks

Delay is an inherent feature of genetic regulatory networks. It represents the time required for the assembly of functional regulator proteins. The protein production process is complex, as it includes transcription, translocation, translation, folding, and oligomerization. Becau...

Causal Relationship Network of Risk Factors Impacting Workday Loss in Underground Coal Mines

Purpose: To explore relationships with post-event workday loss in U.S. underground coal mines using Grouped Greedy Equivalence Search (GGES), a prior-knowledge-constrained extension of GES. Methods: The analysis utilizes data obtained from the National Institute for Occupational...

“New Way to Look at Shared Problems”: Team Science in Special Education Research

In special education, the complexity of serving individuals with disabilities and their families necessitates sustained interdisciplinary collaboration. However, little is known about how the principles of team science are valued and enacted within higher education programs that...

Sex work or male-with-male sexual activity and the risks of HIV and hepatitis C acquisition among people who inject drugs: a global systematic review and meta-analysis

Background People who inject drugs (PWID) may engage in sexual behaviours that increase their HIV and hepatitis C virus (HCV) risk, including sex work and male-with-male sexual activity. We undertook a global systematic review to assess whether PWID who engage in these behaviours...

Acute Effects of Impella 5.5 on Biventricular Filling and Pressure–Volume Area in Patients With Heart Failure Associated Cardiogenic Shock

Use of Impella 5.5 in patients with decompensated heart failure-associated cardiogenic shock (ADHF-CS) is increasing as a bridge to advanced therapies. The effects of maximal trans-valvular unloading on biventricular filling and pressure–volume area (PVA) in ADHF-CS are poorly un...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

The Use of Generative Artificial Intelligence by Psychology Graduate Students in the United States

Background Although developed only recently, generative artificial intelligence (AI) applications for everyday use (e.g., ChatGPT) have become part of university life. The academy must navigate AI use in graduate education within several domains (coursework, teaching, research, c...

Risk of Degenerative Spine Disease, Interventional Spine Procedures and Spine Surgery in Patients with Multiple Sclerosis

OBJECTIVES: To determine the association between Multiple Sclerosis (MS) and Degenerative Spine Disease (DSD) and the subsequent utilization of interventional pain (IVP) procedures and spine surgery. DESIGN: A retrospective, active comparator cohort study using TriNetX. Adults wi...

Advanced biochar hybrid systems for adsorptive removal of water contaminants: Progress, mechanisms, and future directions

Abstract Contamination of aquatic systems by organic materials, heavy metals, pharmaceuticals, dyes, pesticides, and emerging pollutants is a pressing problem not only for aquatic systems but also for human health. Among the various treatment technologies, adsorption is among the...

Clinical Development of Antibacterial Drugs: Recent Progress and Future Outlook

The growing burden of antibiotic resistance demands the development of new antibacterials, including those with novel targets and mechanisms of action. This review summarizes key antibacterials that were in clinical development from 2010 to 2026, highlighting their antibacterial...

Latexin deletion in the bone marrow niche suppresses leukemia via LIFR downregulation and immune activation

Acute myeloid leukemia (AML) is the most common adult leukemia diagnosis. Bone marrow (BM) niche significantly influences the initiation and progression of AML. However, our knowledge about the effect of leukemic niche on leukemia stem cells (LSC) and leukemogenesis is limited. I...

Developmental bias of body size and caste by the fire ant social supergene

Abstract Supergenes are clusters of linked genes that drive complex phenotypic divergence. In the fire ant Solenopsis invicta, a supergene determines polymorphic social organization, and its derived (b) haplotype is over-represented among large workers and gynes relative to the a...

Contact Resistance at Interfaces Buried Within Organic Transistors Imaged Using Scanning Microwave Impedance Microscopy

Contact resistance has been a consistent challenge in the 40-year history of the organic thin-film transistor (OTFT). The problem arises because contact resistance at the metal electrode/organic interface is an amalgamation of physical phenomena: From ubiquitous defect states and...

Directing the Labor Market: Shared Directors and Employee Flows

Abstract Using résumé data on over 20 million U.S. workers, we find that the flow of employees between a pair of firms sharply drops by about 20% during periods in which the firms share a board director. This relationship is stronger in settings where firms have greater potential...