Paracelsus Medical University

Chimeric Antigen Receptor T‐Cell Therapy in T Cell/Histiocyte‐Rich Large B‐Cell Lymphoma: A Systematic Review and Meta‐Analysis

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare subtype of B-cell non-Hodgkin lymphoma with an aggressive clinical course and poor prognosis in the case of relapsed or refractory (r/r) disease. Recently, anti-CD19 chimeric antigen-receptor (CAR) T-cell therapy ha...

Exploring Pathophysiological Processes Shared Between Type 2 Diabetes Mellitus and Osteoarthritis

Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are highly prevalent chronic disorders with increasing global burdens that frequently coexist and share common risk factors, including obesity, aging and chronic low-grade inflammation. This narrative review aims to summariz...

Vitamin D status and adiposity in children with low-energy fractures: a prospective case–control study

Fractures in children are influenced by both skeletal biology and mechanical factors. While alterations in vitamin D and other metabolic markers have been proposed as contributors to fracture risk, their role in predicting fractures in otherwise healthy pediatric populations rema...

Deep whole genome sequencing of epileptogenic brain lesions

Abstract Objective Malformations of cortical development and low‐grade epilepsy‐associated tumors often cause drug‐resistant lesional focal epilepsy (LFE) amenable to surgical treatment. Genetic testing of resected brain tissue can provide diagnostic and mechanistic information a...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Determination of inter-individual differences in humeral head centre translations in subjects with healthy shoulders

Abstract The aims of this study were to (i) quantify glenohumeral (GH) joint translations in healthy shoulders, (ii) assess subject-specific variability in GH translations, (iii) determine whether bony joint geometry (glenoid height, width, retroversion, inclination, GH aspherici...

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

Place and cause of death among people with chronic neurological diseases in Munich: a population-based study using death certificates

Abstract Introduction Access to palliative care is often delayed and fragmented for patients with chronic neurological diseases. This study aimed to characterize the place and cause of death among individuals with chronic neurological diseases to help identify potential gaps in p...

Febrile seizures in pediatrics

Abstract Background A febrile seizure (FS) is the most common type of seizure without underlying neurological disease in pediatrics. Due to their sudden onset and striking symptoms, FS cause uncertainty among parents and medical staff. This places high demands on the healthcare s...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

TAPESTRY study: impact of prior transurethral resection of the prostate on outcomes after robot-assisted radical prostatectomy: a propensity score-matched cohort study

Abstract Prior transurethral resection of the prostate (TURP) may distort bladder neck and apical anatomy and complicate robot-assisted radical prostatectomy (RARP). Its effect on anastomotic recovery and oncological control remains controversial. To evaluate perioperative, anast...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

Exploring patients' and family members’ perspectives on intensive care unit experiences through unsolicited feedback: A qualitative content analysis

Background Intensive care unit (ICU) stays are profound and distressing experiences for critically ill patients and their family members, often resulting in physical, psychological, cognitive, and social sequelae. Existing knowledge stems largely from structured interviews or que...

THE REPRODUCTION OF THE NATIVE LAXITY PHENOTYPE GUARANTEES A MORE NATURAL KNEE KINEMATICS COMPARED TO THE RESTORATION OF THE STATIC MORPHOTYPE: A GAIT ANALYSIS EVALUATION FOLLOWING TOTAL KNEE ARTHROPLASTY

Introduction Alternative alignments in total knee arthroplasty (TKA) are gaining popularity over mechanical alignment because they aim to replicate patients’ natural alignment and restore the original joint line position and obliquity as measured on preoperative weight-bearing X-...

Predictors of Severe Course in Odontogenic Cervicofacial Infections: A Prospective Multicenter Cohort Study

Background: Odontogenic cervicofacial infections are prevalent and can progress to life-threatening conditions, imposing a substantial burden on both patients and healthcare systems. The present study evaluated the association of presentation delay and comorbidities with clinical...

From load-bearing to load-sharing: contact-driven transitions in locked plate constructs

Abstract Locked plate osteosynthesis functions as an internal fixator, yet load-induced plate–bone and fragment–fragment contacts – key transitions from load-bearing to load-sharing – remain poorly characterized. This study quantified their effects on construct stiffness, plate s...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...

AI-Derived Pericardial Effusion Volume and Long-Term Mortality After Transcatheter Aortic Valve Implantation

Background: Pericardial effusion is a common finding on pre-procedural computed tomography (CT) in patients undergoing transcatheter aortic valve implantation (TAVI). However, its clinical significance remains uncertain. Using artificial intelligence (AI)-based image analysis, we...

Disentangling the role of adaptive immunity in Alzheimer’s disease

Abstract Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is characterized by progressive synaptic and neuronal loss, amyloid-β deposition, hyperphosphorylated tau accumulation, and chronic neuroinflammation, traditionally attributed primarily to...