Uppsala University

Clinical Outcomes of Fixed Dental Prostheses Supported by Teeth or Implants in the Posterior Region—A Long‐Term Retrospective Multicenter Study

BACKGROUND: Few long-term studies compare tooth- and implant-supported fixed dental prostheses (FDPs) in the posterior region. OBJECTIVES: To compare the 5- and 10-year survival and complication outcomes of tooth- and implant-supported FDPs and to assess patient-reported effects....

Structure-guided allosteric modulation of the delta opioid receptor

Abstract Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid anal...

A comprehensive review of ferrite-based electrical motors for electric vehicle applications

This paper presents a comparative review of ferrite-based traction motors for electric vehicle (EV) applications. While numerous studies have examined ferrite-based motor designs in isolation, the literature still lacks a systematic comparative assessment across three levels: (i)...

Familial Co‐Aggregation of Neurodevelopmental Conditions and Childhood‐Onset Type 1 Diabetes

ABSTRACT Aim Childhood‐onset Type 1 diabetes (T1D) is associated with neurodevelopmental conditions (NDCs). We examined whether this association extends to relatives and assessed phenotypic, genetic, and environmental correlations between T1D and NDCs. Methods Using Swedish regis...

P1.223. Outcomes After Oesophageal Resection in Octogenarians: A Nationwide Population-Based Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background The incidence of oesophageal cancer increases with age, yet octogenarians remain underrepresented in surgical series. Evidence regarding the safety and oncologi...

An additional water is introduced into the manganese cluster during the formation of the S3 state of photosystem II

During photosynthetic water oxidation, the Mn4Ca cluster in Photosystem II progresses through five intermediate Si (i = 0–4) states. X-ray crystallography studies have reported the insertion of one new O ligand during the formation of the S3 state, but recent studies question the...

Why food stays contaminated: a COM-B framework analysis of child feeding practices in Dhaka’s informal settlements

Abstract Background Foodborne diseases are the major public health concerns in low- and middle-income countries, particularly during the complementary feeding period. Children become increasingly exposed to environmental pathogens at this age. Food hygiene during this period is c...

Complementary strengths of the Neyman-Rubin and graphical causal frameworks

This article contributes to the discussion on the relationship between the Neyman-Rubin and the graphical frameworks for causal inference. We present specific examples of data-generating mechanisms — such as those involving undirected or deterministic relationships and cycles — w...

“Acknowledge my grief” - experiences and needs of bereavement support in Sweden following the death of a loved one

<title>Abstract</title> Background Grief affects most people at some point, and is commonly associated with psychological distress, reduced well-being, and difficulties in everyday functioning. Support for the bereaved is crucial for grief management, but there is a lack of evide...

Induction of type I and III interferons by viral and endogenous stimuli in systemic sclerosis

ABSTRACT Objective The interferon (IFN) system is activated in systemic sclerosis (SSc), but the driving mechanisms remain unclear. We asked whether type I and III IFN responses to Toll-like receptor (TLR)-7/8/9 stimulation of leukocytes from patients with SSc differ from healthy...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Dual-Channel Energy Transfer from Ligand-Centered Singlet and Triplet States to Trivalent Lanthanide Ions

Abstract Efficient light harvesting and subsequent energy transfer (EnT) to trivalent lanthanide ions (LnIII) are critical for achieving high-performance luminescent LnIII complexes. However, because of the complexity of the underlying dynamic processes, in-depth investigations o...

Dating low-temperature hydrothermal fluid activity with in situ Rb/Sr geochronology of partially chloritized biotite

Chloritization of biotite by fluids is common in low-temperature tectonic regimes. Using three metapelites from the Tatric Superunit in the Western Carpathians (northern Slovakia), we demonstrated that in situ Rb/Sr geochronology of partially chloritized biotite can be used to da...

The support program Parenting Young Children for parents with intellectual and developmental disabilities: parents’ experiences of the program’s impact on their parenting

Parenting Young Children is a home-based parenting support program for parents with intellectual and developmental disabilities. The program focuses on parents’ ability to care for and interact with their children and is adjusted to each parent’s needs through individualised goal...

Trajectories of refraction and strabismus from 2.5 to 12 years in a national cohort of extremely preterm children‐ the Extremely Preterm Infants in Sweden Study (EXPRESS)

Abstract Purpose To investigate the longitudinal development of refraction and strabismus in a national cohort of children born extremely preterm (EPT) and find relations to perinatal events and neurodevelopmental outcomes. Methods All surviving children born &lt;27‐gestation wee...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

Retired doctors as users of patient-facing electronic health records: a mixed-methods survey in the UK and Spain

<title>Abstract</title> Background Online patient access to electronic records is expanding internationally but remains contested. Although clinicians’ concerns are well documented, less is known about how doctors’ views change when they themselves become patients. Retired doctor...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

Deciphering the evolutionary origin of the enantioselectivity of short-chain dehydrogenases from plants toward 1-borneol

Abstract Enzyme engineering has produced numerous methods to optimize enzymes for biotechnological processes; however, less is known about how natural evolution creates new functionalities. We investigate the evolutionary emergence of enantioselectivity in plant borneol dehydroge...

Solvent‐Induced Structural Modulation in Nanoscale Covalent Organic Frameworks Enables High‐Performance NO 2 Sensing

ABSTRACT Covalent organic frameworks (COFs) offer exceptional structural and functional tunability, enabling performance optimization in separation, catalysis, and sensing applications. Here, we report a solvent‐induced strategy for inducing structural disorder in porphyrin‐based...