Uppsala University

Vancomycin therapeutic drug monitoring: trends and seasonal patterns

Vancomycin is widely used for serious Gram-positive infections, but its narrow therapeutic index necessitates therapeutic drug monitoring (TDM). Over recent decades, monitoring has shifted from trough-based to AUC-guided dosing. This study investigated long-term trends in vancomy...

Governing Solar Geoengineering at Planetary Scale: Pipe Dream or Possibility?

Solar geoengineering is being suggested by some scientists as a partial solution to the climate crisis. However, these hypothetical technologies to reflect parts of incoming sunlight back out into space pose significant governance challenges, due to their ecological risks, planet...

Longitudinal Modeling of Cardiometabolic Dysfunction in Patients With Type 2 Diabetes Using Item Response Theory

ABSTRACT Cardiometabolic dysfunction in patients with type 2 diabetes (T2D) is reflected by multiple risk factors and cannot be fully characterized by any single biomarker. Item response theory (IRT) provides a framework for integrating observed risk factors into latent measures...

Challenges and strategies in the multicultural sexual and reproductive healthcare encounter - a qualitative study on the perspectives of health professionals

BACKGROUND: Sexual and reproductive health (SRH) in Sweden is shaped by strong equity and gender-equality ideals, yet migrant patients continue to experience disparities in SRH outcomes. Social, cultural, and structural factors can complicate clinical encounters, potentially posi...

Multilevel phylogenetic inference of syntactic harmony in Indo-European

Abstract One of the most well-established typological universals is that languages tend to order the grammatical head and its dependents consistently. This harmonic principle has been attributed to cognitive benefits that facilitate language processing and learning efficiency. Ho...

Autonomic function and signal complexity reflect level and severity of traumatic spinal cord injury

Abstract Study design Observational single-centre cohort study. Objectives To investigate heart rate variability (HRV), baroreflex sensitivity (BRS), and signal complexity (SC) and their relationships with neurological injury level and severity, as well as their prognostic value...

Improvement in peripheral airway function after a 12-week exercise intervention in COPD

Abstract Background Exercise is a cornerstone of chronic obstructive pulmonary disease (COPD) management and improves quality of life, exercise capacity, exacerbation frequency and survival. However, the physiological mechanisms underlying these effects remain unclear. Small airw...

On ARX modeling with the ASYM method for errors-in-variables problems

ARX models are often used in system identification. Using high-order ARX models one can well describe arbitrary output noise. Combining high-order ARX models and model reduction techniques, several two-step identification methods are formed, such as the asymptotic method (ASYM) (...

Design, Synthesis, and Comparative Selection Analysis of a Chemically Diverse Peptide-Like DNA-Encoded Library

Abstract DNA-encoded chemical library technology offers a cost-effective method for screening billions of compounds in a single experiment. However, achieving broad coverage of lead-like chemical space remains challenging. Here, we describe the design and synthesis of a three-cyc...

TSD: An Inverse Problem Approach for Recovering the Exoplanetary Atmosphere Transmission Spectrum from High-resolution Spectroscopy

Abstract Our ability to observe, detect, and characterize exoplanetary atmospheres has grown by leaps and bounds over the last 20 yr, aided largely by developments in astronomical instrumentation, improvements in data analysis techniques, and an increase in the sophistication and...

Switching for the better? understanding how contextual conditions influence patients’ choice of primary care provider

Abstract Background Considering current expectations that patients will stimulate competition based on quality among healthcare providers through informed choices, this study aims to advance understanding of patients’ limited engagement in choosing a primary care provider. Method...

A supergene and genomic mosaicism are associated with phenotypic evolution in Galápagos tree finches

Abstract Adaptive radiations provide powerful models to study the origins of phenotypic novelty and species diversity. Darwin’s finches constitute a classic example of adaptive radiation, in which beak morphology is a key trait related to fitness. Here, we focus on Camarhynchus t...

CNS localization drives a profoundly immunosuppressive microenvironment in B‑cell lymphoma

Abstract Primary central nervous system lymphoma (PCNSL) has significantly poorer outcomes than peripheral diffuse large B-cell lymphoma, suggesting need for novel therapies and a deeper understanding of the unique tumor immune microenvironment (TIME) within the brain. To investi...

Long‐COVID Associated With Incident Hypertension: A Population‐Based Cohort Study

Background Long COVID has been linked to persistent autonomic and vascular abnormalities, but its impact on hypertension among non‐hospitalized COVID‐19 convalescents remains unclear. Given the link between blood pressure and cardiovascular morbidity, understanding how long COVID...

On the Discovery of the First Tetrapod Burrow from the Pennsylvanian-Age Clifton Formation, Stonehaven, New Brunswick, Canada

Reported trace fossils from the Clifton Formation, New Brunswick, Canada, are limited to a single occurrence of a temnospondyl trackway and invertebrate trackways identified in the Pennsylvanian continental strata. Our study builds on this with a description of a horizontal burro...

Phase control of interfering stimulated Raman pathways in the XUV regime

Abstract Coherent control uses interference between quantum pathways to enhance or suppress transitions to a target quantum state. In stimulated Raman excitation, such control can be achieved through interference between two indistinguishable pathways connecting the same initial...

That’s So Retro: The Gaia-Sausage-Enceladus Merger Trajectory as the Origin of the Chemical Abundance Bimodality in the Milky Way Disk

Abstract The Milky Way (MW) is thought to have experienced a ∼3:1 mass-ratio merger event near redshift z ∼ 2 with a significantly retrograde trajectory. This now-disrupted dwarf galaxy is commonly known as the Gaia-Sausage-Enceladus (GSE). In this paper, we investigate the impac...

Noncentrosymmetric Manganese Bismuth Thiocyanate Perovskites

Abstract Symmetry-lowering orderings in perovskites can produce a wide range of functions. Thiocyanate based perovskites, AM(SCN)3, have orderings distinct from those of the atomic oxides, enabling new functional behavior. We report four new defect-ordered manganese thiocyanate p...

Andreev exceptional points in Josephson junctions formed by minimal Kitaev chains

We consider Josephson junctions formed by two minimal Kitaev chains and investigate how the interplay between non-Hermiticity and superconducting phase difference enables the realization of stable topological states that do not exist in the Hermitian realm. In particular, we focu...

No effect of short‐term exposure to ocean acidification on individual‐level variation in behaviour and susceptibility to predation in a Great Barrier Reef damselfish

Abstract Ocean acidification, caused by rising carbon dioxide (CO 2 ) in the atmosphere, has been reported to negatively impact a wide variety of behaviours in fishes, including activity, exploration, and predator avoidance. These effects have been documented at the population le...