Administração Regional de Saúde de Lisboa e Vale do Tejo

Assessing Behavioral and Environmental Facets of Obesity Unobtrusively Utilizing Digital Tools: Introducing the BETTER4U Indicators

ABSTRACT Understanding obesity involves evaluating numerous contributing factors. Collecting the necessary data for this can impose a significant burden on both research participants during clinical studies and real‐life deployments of digital tools aiding obesity management. The...

Unilateral Scrotal Darkening as an Unusual Neonatal Finding: A Case Report

Neonatal testicular torsion (NTT) is a rare condition that carries a substantial risk of ischemia, necrosis, and subsequent testicular loss.When the event occurs before birth, it is classified as prenatal torsion, a typically non-acute entity with an incompletely understood patho...

Synthetic Cannabinoids: Metabolism, Biomarkers of Exposure and Advanced Analytical Strategies in Forensic and Clinical Toxicology

In the last twenty years, synthetic cannabinoid receptor agonists (SCRAs), also frequently known as synthetic cannabinoids, have grown into one of the leading and structurally diverse types of new psychoactive substances. This has brought about major trouble for clinical and fore...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Orthopaedic Management of Bone Metastases from Lung Cancer

Background/Objectives: Bone metastases from lung cancer can cause pain, pathological fracture, spinal instability, metastatic spinal cord compression and loss of independence. Lung cancer-specific evidence for orthopaedically relevant local management remains fragmented. This rev...

Prior percutaneous coronary intervention versus deferral in patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis of randomized controlled trials

Background Coronary artery disease (CAD) is highly prevalent among patients undergoing transcatheter aortic valve implantation (TAVI), yet the optimal management of concomitant coronary lesions remains uncertain. While routine percutaneous coronary intervention (PCI) prior to TAV...

Central nervous system manifestations in hereditary transthyretin amyloidosis: a cross-sectional study with 151 patients

Abstract Background Central nervous system (CNS) dysfunction is increasingly recognized in hereditary transthyretin (ATTRv) amyloidosis. We aimed to characterize CNS manifestations and assess associations with clinical variables and plasma neurofilament light chain (NfL), using h...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Trends in Hospitalization, Case Fatality, and Mortality for Community-Acquired Pneumonia in Portugal over 20 Years

Background: Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality worldwide and a major driver of hospital admissions. Older adults are disproportionately affected, owing to immune senescence and a higher prevalence of chronic comorbidities. This s...

Clinical Outcomes of Patients Ineligible for Arteriovenous Vascular Access: A Retrospective Cohort Analysis

ABSTRACT Background A subset of patients with advanced chronic kidney disease (CKD) or kidney replacement therapy becomes ineligible for arteriovenous vascular access creation due to vascular exhaustion or comorbidity‐driven contraindications. Outcomes following a negative surgic...

Calcium-mediated force–interval relationship drives post-extrasystolic potentiation in premature ventricular complexes: a computational study

Abstract Premature ventricular complexes (PVCs) are common cardiac arrhythmias that can lead to cardiomyopathy when frequent. Post-extrasystolic potentiation (PESP), which is the transient increase in contractility following a PVC, may serve as a predictive marker for heart failu...

Myeloma Elderly Prognostic Score ( MEPS ): A Proposed Prognostic Score Integrating Age, Renal Function, Performance Status, and Ultra‐High‐Risk Cytogenetics

Established disease-centered prognostic systems may be less tailored to elderly/non-transplant-eligible (NTE) patients with multiple myeloma (MM), in whom host-related factors such as age, performance status, and renal function strongly influence all-cause outcomes. We developed...

Impact on health outcomes of treating all eligible large B-cell lymphoma patients with axicabtagene ciloleucel in Portugal – A modeling approach

AIM: This study aimed to quantify the health benefits that can be achieved by treating axicabtagene-ciloleucel (axi-cel)-eligible large B-cell lymphoma patients with axi-cel instead of historical standard of care (hSoC) in Portugal. "Estimated Opportunity Lost" quantified the dif...

Research Priorities in Perioperative Nursing Across the Lifespan: An e-Delphi Consensus Study

Background/Objective: Perioperative nursing care encompasses a diverse patient population with varying needs, anatomical and physiological characteristics, and differing levels of vulnerability, demanding specialized knowledge and skills. This study aims to identify key research...

The Stabilization Technique for Ankle Lateral Repair: An All‐Inside 2‐Portal Arthroscopic Repair With Knotless Suture Anchors and Suture Tape Augmentation

Abstract Lateral ankle sprains are among the most frequent injuries encountered in sports, with the anterior talofibular ligament being the structure most often affected. Although many individuals achieve full recovery, a substantial number experience chronic lateral ankle instab...