NIHR Imperial Biomedical Research Centre

Frequency of plastic occurrence varies across phylogeny but not ecology in seabirds

Seabirds are especially vulnerable to ingesting plastic pollution. However, we have a limited understanding of which traits might increase their risk of plastic ingestion. Here, we use a dataset of seabird plastic occurrence records (93 281 birds from 240 species) to investigate...

Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8⁺ T-cell clonal dominance in head and neck cancer

Abstract Concomitant chemoradiotherapy (CRT) is a standard-of-care treatment for unresectable locally advanced head and neck squamous cell carcinoma (LA-SCCHN), but its immune effects, particularly relative to radiotherapy (RT) alone, remain incompletely understood. Using syngene...

Natural methane emissions feedbacks in MAGICC v. 7.6

Literature estimates of natural methane emissions, particularly from wetlands, have a wide range of uncertainty. Meanwhile, few Earth System Models (ESMs) explicitly model wetlands as a potential source of methane. As a result, Simple Climate Models that aim to emulate the behavi...

Generational changes in lung function in adults from several world regions: results from the Burden of Obstructive Lung Disease study

This study estimated birth cohort effects on lung function using BOLD (Burden of Obstructive Lung Disease) data from 28 569 adults born between 1902 and 1976 across 41 sites in 34 countries. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ) and the FEV 1 /FVC...

The Cloud Feedback Model Intercomparison Project (CFMIP) contribution to CMIP7

Cloud processes constitute one of the key uncertainties for climate change projections. The fourth iteration of the Cloud Feedback Model Intercomparison Project, CFMIP4, contributes to the Coupled Model Intercomparison Project phase 7 (CMIP7), by providing a set of global climate...

Exhaled breath aerosol sampling for detection of pulmonary tuberculosis in adults: a study protocol for an exploratory diagnostic accuracy study

Introduction Tuberculosis remains a major global health challenge, causing over one million deaths annually. Current diagnostic techniques depend on restrictive sputum sampling. Better sampling methods are needed to enable early detection and effective management. This study intr...

Spatially Decoupled Electron and Lithium Storage at Fe/Solid Electrolyte Interphase Interfaces

ABSTRACT Extra lithium storage in transition‐metal nanoparticles remains debated because interfacial reactions are difficult to distinguish. Using Fe/C as a model anode, we combine in situ electron paramagnetic resonance (EPR) and magnetometry to resolve two concurrent storage pr...

Demonstration of how group model building can be used to understand barriers and facilitators to “at-risk” young people’s access to community assets for mental health support: a participatory study

Abstract Background Community assets (e.g. green spaces, youth centres) can support the mental health of young people. However, less is known about barriers and facilitators to access these assets. This manuscript aims to demonstrate how group model building – a participatory res...

Human cortical networks trade communication efficiency for computational reliability

Brains are often described as cost-efficient communication networks, optimally balancing the cost of long connections with the benefits of fast communication. Here, inspired by the "use it or lose it" principle, we present a novel game-theoretic model of self-organizing neural un...

22 Quality of life and services use in patients diagnosed with brain tumours: data from a national cancer survivorship study

Abstract Introduction About 13,000 new patients are diagnosed annually with a primary brain tumour in the UK and less than 20% of patients survive 10 years post-diagnosis. Patient-Reported Outcomes and Experiences (PROMs & PREMs) are largely used in clinical trials that recruit f...

Factors for Success and Failure of Allergen Immunotherapy ( AIT ) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergen immunotherapy (AIT) has been acknowledged as the only disease-modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study res...

Mapping System Vulnerabilities in Anaesthesia Safety: A Role‐Based Inquiry in Response to Fatal Fungal Meningitis Outbreaks in Mexico

ABSTRACT Objectives Unsafe anaesthesia practices in Mexico have contributed to repeated outbreaks of fatal fungal meningitis, exposing broader health system vulnerabilities. This study aimed to analyse how structural weaknesses in perioperative care, spanning governance, workforc...

The Zooplankton International Geospatial dataset: A global repository of spatiotemporal freshwater zooplankton community composition data from lakes and reservoirs to support ecological research

Abstract Zooplankton transfer substantial energy in aquatic food webs and are used as indicators of environmental change. Syntheses of zooplankton community dynamics globally require datasets that span a wide range of environmental gradients; however, these datasets are limited d...