Yale University

Portable Low-Field MRI of the Brain in Clinic and Community Settings

This cohort study evaluates portable, low-field magnetic resonance imaging (MRI) against conventional MRI in memory clinic and community cohorts.

Making the Case: Demonstrating the Value of Pediatric Hospital Medicine to Hospital Leadership

Pediatric hospital medicine (PHM) has become a foundational component of inpatient pediatric care; however, its value is frequently evaluated through a narrow financial lens. This C-suite series piece examines how PHM's contribution to 'value' encompasses not only professional re...

26. MULTI-ANCESTRY STRUCTURAL VARIANT ASSOCIATIONS WITH ALCOHOL USE DISORDER USING SRWGS FROM THE ALL OF US RESEARCH PROGRAM

Background Alcohol use disorder (AUD) genetic risk is only partly captured by common single-nucleotide variants identified through genome-wide association studies (GWAS). Structural variants (SVs), a broad class of genomic alterations including deletions (DELs), duplications (DUP...

MULTI-ANCESTRY GWAS OF GENERALIZED ANXIETY DISORDER IN THE MILLION VETERAN PROGRAM

Generalized anxiety disorder (GAD) remains underpowered in genetic studies relative to other psychiatric traits. We conducted a multi-ancestry genome-wide association study (GWAS) of GAD in the Million Veteran Program (MVP), including 42,130 cases and 580,993 controls across Euro...

Inscribing chölkha : Census, election, and the making of modern Tibetan diaspora identity

Abstract This article examines the historical formation of modern chölkha identity, a cornerstone of contemporary Tibetan nationalist thought. Rather than a direct continuation of medieval Tibetan identity categories, this article argues that modern chölkha identity is a continge...

27. EPIGENOME-WIDE ANALYSIS REVEALS DISTINCT DNA METHYLATION PROFILES FOR OPIOID DEPENDENCE VERSUS OPIOID EXPOSURE

Background The U.S. opioid epidemic represents a serious public health crisis. While epigenetic mechanisms have been linked to opioid use disorder (OUD), more research is needed to identify actionable biomarkers that distinguish opioid exposure from opioid dependence. In this stu...

POWER, REPLICATION, AND EPIGENETIC SIGNAL IN PSYCHIATRIC DISORDERS: CONTRASTING METHYLOME-WIDE ASSOCIATION STUDIES OF MAJOR DEPRESSIVE DISORDER AND GENERALIZED ANXIETY DISORDER IN THE MILLION VETERAN PROGRAM

Epigenome-wide association studies (EWAS) of psychiatric disorders have historically been limited by modest sample sizes, contributing to inconsistent findings and poor replication. Leveraging DNA methylation data from the Million Veteran Program (MVP), we conducted large-scale m...

Supine Versus Standing Pelvic Radiographs Yield Significantly Different Radiographic Parameters in Femoroacetabular Impingement and Hip Dysplasia: A Systematic Review and Meta‐analysis

Purpose To compare radiographic parameters obtained from supine versus standing pelvic radiographs in patients with femoroacetabular impingement (FAI) and acetabular dysplasia (AD). Methods This study was registered on the International Prospective Register of Systematic Reviews...

“By Helping Others, I Help Me”: Examining the Impact of the Sawubona Healing Circle—A Qualitative Study

Ongoing anti-Black racism impacts daily life for many Black people across the globe. The Association of Black Psychologists developed the Sawubona Healing Circles (SHCs) for Black people to have a space to process and heal from anti-Black racism. The objective of this qualitative...

Running to Stand Still: EHR Efficiency and Workload Across Emergency Medicine Residency

ABSTRACT Objectives The evolution of electronic health record (EHR) burden throughout emergency medicine (EM) residency remains poorly understood. We aimed to quantify EHR use, the composition of work performed outside scheduled hours, and the development of EHR efficiency across...

Chronic diphenhydramine misuse in a patient with schizophrenia mimicking neurocognitive decline: a case report

Pharming, the misuse of prescription or over-the-counter (OTC) medications for psychoactive effects, represents an emerging public health concern that may be underrecognized. Diphenhydramine (DPH), a first-generation antihistamine, is particularly susceptible to misuse due to its...

Anxiety and mood disorders are associated with greater healthcare and procedural utilization in idiopathic intracranial hypertension

Background and purpose Anxiety and mood disorders (AMD) are common in idiopathic intracranial hypertension (IIH), but their association with procedural treatment and healthcare utilization is unclear. We evaluated utilization among patients with AMD documented before or shortly a...

New Technology for the Treatment of Bone Defects and Limb Length Discrepancies with a Motorized Intramedullary Bone Transport Nail

SUMMARY: Bone defects are among the most challenging problems treated by limb reconstruction surgeons and orthopaedic traumatologists. Bone transport is a biological reconstruction technique which harnesses distraction osteogenesis to create new bone in critical bone defect. This...

Consensus-Based Definitions for Vocal Biomarkers: The International VOCAL Initiative.

Introduction: Voice-based health technologies are growing rapidly, but they lack standardized terminology, which hinders interdisciplinary collaboration, research quality, and clinical translation. The objective of this work was to develop universally accepted definitions in the...

National trends in heart failure and hyperlipidemia related mortality in the United States, 1999–2024

Cardiovascular disease remains the leading cause of death in the United States, with heart failure (HF) and hyperlipidemia substantially contributing to mortality. This study aimed to examine national trends in HF-related mortality with coexisting hyperlipidemia from 1999 to 2024...

Toward actionable biomarkers in psychiatry: a collaborative roadmap for precision clinical trials. An ACNP position paper

Abstract Psychiatric drug development remains constrained by diagnostic heterogeneity, insufficient and inconsistent drug response, high placebo response rates, and the absence of validated biomarkers that can reliably guide patient stratification, trial design, and regulatory de...

Missed Opportunities for Stroke Prevention in Patients With Hypertension: A Retrospective Case–Control Study

BACKGROUND: Hypertension is the leading modifiable risk factor for ischemic stroke, yet the adequacy of preventative hypertension care in routine clinical practice remains suboptimal, potentially representing missed opportunities for stroke prevention. We evaluated the associatio...

Implementation of Community-Based Helicobacter pylori Screening and Navigation in High-Risk Immigrant Communities

Gastric cancer remains a major prevention gap in the United States, disproportionately affecting immigrants from high-incidence regions. Although Helicobacter pylori is the leading modifiable risk factor for non-cardia gastric cancer, systematic and equitable pathways for testing...

Feasibility and acceptability of smartphone-based ecological momentary assessment for monitoring suicidal ideation among gay, bisexual, and other men who have sex with men in Nepal

Background Ecological momentary assessment (EMA) measures suicidal thoughts and behaviors in real-time. This study evaluated the feasibility and acceptability of smartphone-based EMA for suicide prevention among gay, bisexual, and other men who have sex with men (GBMSM) in Nepal....

Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study

BACKGROUND: The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in care and survival for people with thoracic aortic disease (TAD) in England. METH...