Yale University

Estimating genetic correlation jointly using individual-level and summary-level GWAS data

Abstract With the increasing accessibility of individual-level data from genome wide association studies, it is now common for researchers to have individual-level data of some traits in one specific population. For some traits, we can only access public released summary-level da...

RobustCell: a model attack-defense framework for robust transcriptomic data analysis

Abstract Computational methods should be accurate and robust for tasks in biology and medicine, especially when facing different types of attacks, defined as perturbations of benign data that can cause a significant drop in method performance. Therefore, there is a need for robus...

Review of the Acute Interstitial Nephritis (AIN) Risk calculator

The AIN risk calculator was developed to improve non-invasive diagnostic accuracy for acute interstitial nephritis, an asymptomatic and often poorly recognized but potentially reversible cause of acute kidney injury. The equation was developed in a cohort of adult patients who un...

Electroreduction of Activated Esters Catalyzed bya Manganese Complex

Abstract Electrochemical hydrogenation (electrohydrogenation) using electrons and protons as H2 surrogates offers a sustainable alternative to conventional reduction methods. Herein, we report the manganese-catalyzed electroreduction of activated esters employing a derivative of...

From Policy to Practice: A Statewide Model to Expand School-Community Mental Health Partnerships

Abstract Schools are a primary access point for youth mental health services, yet most lack the sustained funding, infrastructure, and partnerships needed to build comprehensive and equitable systems of care. State policy offers a mechanism to address these limitations, but there...

Data-driven prediction of fifteen-year all-cause mortality among 2.3 million individuals in the VA

ABSTRACT We present a data-driven framework to predict 15-year all-cause mortality using outpatient administrative records for 2.3 million Veterans in the largest integrated U.S. healthcare system. Rather than relying on predefined clinical phenotypes, we used the 1,000 most comm...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Fatigue after ischaemic stroke: A five-year longitudinal study of prevalence and latent trajectory subgroups

Objective To investigate the prevalence and longitudinal course of post-stroke fatigue and identify subgroups with distinct fatigue trajectories up to 5 years post-stroke. Design A prospective, longitudinal, multi-centre cohort study. Setting Hospital stroke units in the Central-...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

DOPAL links dopamine dysregulation to neurodegeneration: a translational systematic review and meta-analysis

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is the most reactive dopamine (DA)-derived aldehyde and has been implicated in selective dopaminergic neurodegeneration in α-synucleinopathies, including Parkinson’s disease (PD) and multiple system atrophy (MSA). Here, we present the first...

UltrafastSwitchable Polar and Magnetic Orders byNonlinear Light–Matter Interaction

Abstract An outstanding challenge in materials science and physics is the harnessing of light for switching ferroic orders in, e.g., ferroelectrics. Here, we propose a mechanism through which electrons in few-layer 2D materials excited with above-bandgap light cause ionic structu...

Nanoscale Formation,Structure, and Stability of Phosphate-IronColloids at Anoxic-Oxic Interfaces

Abstract The mobility of phosphorus (P) at anoxic–oxic interfaces is largely controlled by the formation of phosphate-iron (Fe) colloids, yet the nanoscale mechanisms underlying their formation, structure, and stability remain poorly described. Here, we systematically investigate...

Perspectives on an Intervention to Increase Confidence in Newborn RSV Immunoprophylaxis

OBJECTIVES Respiratory syncytial virus (RSV) immunoprophylaxis is efficacious, yet uptake is low in comparison with other recommended newborn interventions. We aimed to identify barriers to and enablers of implementation of an intervention in the well newborn unit to increase par...

LRP5-dependent transport of polyunsaturated fatty acids serves as an immune checkpoint for natural killer cells

Polyunsaturated fatty acids (PUFAs) play a crucial role in tumor development by influencing not only tumor cells but also immune cells within the tumor microenvironment. Here, we explored the mechanisms by which PUFAs are transported and function within immune cells to regulate t...

Physical activity reduces mental health burden in adults with a history of adverse childhood experiences

BACKGROUND: Adverse childhood experiences (ACES) are associated with health issues that can persist into adulthood including mental disorders, behavioral problems, and suicide. Physical activity (PA) is a potential tool in response to these burdens as it is profoundly beneficial...

Oral Contraceptive Use Has Protective Effect Against Ankle Sprains in Women

Background: Ankle sprain (AS) is among the most common musculoskeletal injury, particularly in women. Hormonal fluctuations during the menstrual cycle may contribute to this sex disparity by affecting ligamentous laxity and muscle stiffness. While oral contraceptive pills (OCPs)...

Routine collection of patient reported outcomes in individuals with peripheral artery disease visiting a vascular specialty clinic: workflows, performance metrics, and clinical phenotypes

Patient-reported outcomes (PROs) in peripheral artery disease (PAD) provide valuable insights when assessing meaningful health status improvement after intervention. This study implemented routine PRO workflows in a large academic PAD practice to assess feasibility expressed as c...

Estradiol and Social Withdrawal in Addiction: A Sex-Specific Neuroendocrine Perspective

Abstract Addiction models have traditionally emphasized drug rewards while often underestimating the role of social processes in relapse vulnerability. Converging evidence from preclinical and clinical studies suggests that social withdrawal during substance use and abstinence ma...

Weak and strong memories are equally reactivated during counterfactual learning, but only weak memories are modified

Adaptively updating memories about familiar others is an important social skill. Here, we examined whether strong or weak social memories are more prone to updating when violated. Participants viewed well-known characters’ emotional reactions to food items either repeatedly or on...

Meaning in Religious Contexts: Examining Beliefs in Free Will and Determinism (or Divine Sovereignty and/or Providence) as Christian Meaning Frameworks With Religious Commitment as Moderator in a Moderated Mediation Model

This study examined the associations among beliefs in free will and determinism (or divine sovereignty and/or providence), meaning in life (MIL), and meaning judgment, as well as whether religious commitment moderates these associations. Guided by the Tripartite Meaning in Life M...