Yale University

Dispersive Optical Activity of ( S )-2-Methylaziridine: Intrinsic Properties and Extrinsic Solvation Effects

Abstract The dispersive optical activity of conformationally flexible S-2-methylaziridine (S-2-MeAz) has been investigated experimentally under isolated and solvated conditions to elucidate the impacts of large-amplitude (conformational) and small-amplitude (vibrational) nuclear...

Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG

Abstract Non-invasive recordings using brain electrophysiology provide credible insights into decline in neuronal functioning with age. New approaches are required to translate these results into compelling clinical metrics and meet the global challenge of preserving brain health...

High-performance parallel implementation of spin-free high-order coupled-cluster theories

High-order coupled-cluster theories with iterative triples (CCSDT), perturbative quadruples [CCSDT(Q)], and iterative quadruples (CCSDTQ) provide benchmark-quality correlation energies, but their steep computational scalings, O(N8), O(N9), and O(N10), together with the large memo...

Path dependence in alchemical calculations of water chemical potential in aqueous electrolytes

Accurate calculation of free energies and their derivatives is central to assessing the thermodynamic stability of molecular and particulate systems across length scales. Yet, such quantities can be difficult to compute reliably in strongly interacting systems, such as solutions...

From protogalaxy through thick and thin: Why did the Milky Way evolve in three kinematic phases?

Abstract APOGEE and Gaia data suggest the Milky Way’s kinematic structure evolved through three distinct phases: a disordered protogalaxy, which ‘spun up’ into a thick stellar disk, and then ‘cooled down’ to a final cold, thin stellar disk. We use a suite of FIRE-2 cosmological z...

Genetic Variants in Intracranial Atherosclerotic Disease: A Systematic Review and Targeted Meta‐Analysis Highlighting the RNF213 rs112735431

Background Intracranial atherosclerotic disease (ICAD) is a leading cause of ischemic stroke and premature mortality, with higher prevalence in specific ethnic groups. Multiple studies have evaluated the association of ICAD and genetic variants. This study aims to systematically...

Prior preferences interfere with the associative learning of food values

Addressing unhealthy behaviors requires learning and implementing healthier options. Ecologically, we rarely undergo associative learning in naive environments; our prior preferences confound the learning process. This is perhaps especially true for food, for which we have strong...

Simultaneous PSF Matching via Dual Kernel Optimization

Abstract Standard point spread function (PSF) matching algorithms consider one image as the reference and aim to find a convolution kernel such that, when applied to the reference image, the PSFs of the reference and non-reference images are matched. This method works well if one...

HIV transmission behaviors, detectable HIV-RNA and curable STI prevalence among Ugandan men with HIV with reproductive goals, with and without infertility experiences

Many men with HIV (MWH) want children. MWH with unmet reproductive goals may prioritize conception over preventing HIV/STI transmission. Therefore, we evaluated whether MWH with unmet versus met reproductive goals were more likely to have detectable HIV-RNA or STIs, and explored...

Weaving a theory of change: mapping the pathway for Peer Support implementation in community mental health services in Brazil through co-produced participatory workshops

Abstract Background Peer Support (PS) has gained increasing recognition as a recovery-oriented practice in mental health services by valuing the experiential knowledge of individuals with lived experience of psychological distress. While PS has been widely implemented in high-inc...

Tobacco use moderates associations between cannabis use, psychiatric symptoms, and cognitive performance in psychosis spectrum disorders

Tobacco and cannabis use are highly prevalent among individuals with psychotic disorders. Tobacco use has been consistently linked to poorer clinical and cognitive outcomes, whereas findings regarding cannabis use remain mixed. The present study was a secondary analysis of cross-...

Addressing non-communicable diseases and injuries through an equity lens: insights from the Cameroon non-communicable disease and injury (NCDI) Poverty Commission

Background: Non-communicable diseases and injuries (NCDIs) constitute a leading cause of premature mortality globally, disproportionately affecting low- and middle-income countries (LMICs). To curb the rising burden of NCDIs in Cameroon, the Ministry of Public Health established...

Neonatal Dried Blood Spot Metabolomics Reveals Signatures of Early‐Onset Myeloproliferative Neoplasms

ABSTRACT The etiology of myeloproliferative neoplasms (MPN) is poorly understood. We investigated the possible role of early‐life exposures in the pathogenesis of MPN diagnosed among children and young adults in a population‐based case–control study in California. Untargeted meta...

Facilitating best practices in practicum training in clinical neuropsychology: introducing the North American Association of practicum sites in neuropsychology (NAPSN) organizational training guidelines

INTRODUCTION: The North American Association of Practicum Sites in Neuropsychology (NAPSN) was established in 2023 to support external practicum programs in urban, suburban, and rural areas in the United States and Canada by providing resources for member practicum programs and s...

INCREASED PREVALENCE OF PANCREATIC CYSTS IN NONSECRETOR (FUT2 NULL) INDIVIDUALS UNDER PANCREATIC SURVEILLANCE

Abstract Background: Pancreatic surveillance commonly detects pancreatic cysts, most of which are presumed intraductal papillary mucinous neoplasms (IPMN). FUT2, the gene responsible for secretor status, has been implicated in IPMN development, although not with pancreatic cancer...

Targeted Analysis of >1500 Plasma Proteoforms via Individual Ion Mass Spectrometry

Abstract Plasma proteomics has emerged as a powerful approach for interrogating human biology, identifying disease-associated proteomic changes, and advancing precision diagnostics. In recent years, affinity-based plasma proteomics platforms with predefined protein panels, such a...

Demystifying Prediction-Powered Inference

Machine learning predictions are increasingly used to supplement incomplete or costly-to-measure outcomes in fields such as biomedical research, environmental science, and social science. However, treating predictions as ground truth introduces bias while ignoring them wastes val...

Teaching the past, informing the present? School history education and attitudes toward foreign countries

Abstract How does school history education emphasizing past grievances with other countries impact attitudes toward conflict and cooperation with the countries today? We examine this question using original data from 34 classrooms across 17 high schools in Seoul, South Korea. We...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Entropic Optimal Transport Eigenmaps for Nonlinear Alignment and Joint Embedding of High-Dimensional Datasets

Abstract. Embedding high-dimensional data into a low-dimensional space is an indispensable component of data analysis. In numerous applications, it is necessary to align and jointly embed multiple datasets from different studies or experimental conditions. Such datasets may share...