Yale University

0057Online Prescribing of GLP-1 Receptor Agonists: A Secret Shopper Study

Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and compounded GLP-1RAs—non-FDA approved GLP-1RAs—have become widely available online. Prior telehealth website review suggested limited clinician engagement in obtaining online prescriptions. The extent of clinical...

Per- and polyfluoroalkyl substances levels other than PFOS, PFOA, or PFHxS and liver cancer risk: a nested case-control analysis

Abstract Epidemiologic studies of PFAS and liver cancer risk have produced conflicting results with no strong or clear associations for pre-diagnostic perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS). We now report analyses of nine...

The Syrian Abdāl : The Development of Muslim Eremitic Asceticism on the Black Mountain in the Early Abbasid Period

This article reconstructs an understudied tradition of early Muslim eremitic asceticism centred on Syria’s mountainous frontier, particularly the Black Mountain (Jabal al-Lukkām) and Mount Lebanon, from the eighth through tenth centuries. Drawing primarily on Sufi biographical li...

COVID-19 lockdown and coverage of maternal health and nutrition care in rural West Bengal, India: a single interrupted time-series analysis

Abstract While COVID-19 lockdowns globally disrupted healthcare, the extent of changes in India’s maternal health and nutrition services coverage in rural settings requires further empirical investigation. Utilizing data from 57,371 pregnancies recorded between January 2012 and D...

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

Obesity, hypertension, and hyperuricemia among people living with HIV in Ghana: a cross-sectional study

Abstract Hyperuricemia is highly prevalent among people living with HIV (PLHIV), yet the influence of obesity and hypertension on hyperuricemia remains poorly characterized in sub-Saharan Africa. This study aimed to quantify the association between obesity and hyperuricemia and t...

Menopausal hormone therapy and primary liver cancer: long-term follow-up of the women’s health initiative randomized trials

Abstract Background: Long-term results on liver cancer incidence and mortality are reported from two Women’s Health Initiative randomized trials evaluating menopausal hormone therapy. Methods: 16,608 postmenopausal women with a uterus were randomized to conjugated equine estrogen...

Longitudinal predictors of internalizing and externalizing behaviors in autism: Examining relationships with ritualistic behavior and social diagnostic features

Abstract Autistic youth commonly experience co-occurring mental health conditions. Core autism features have been linked to internalizing and externalizing symptoms, yet longitudinal pathways remain unclear. This study examined how ritualistic and social diagnostic features predi...

Engineered Orthogonal Translation Systems from Metagenomic Libraries Expand the Genetic Code

Abstract Genetic code expansion with noncanonical amino acids (ncAAs) opens new opportunities for the design and engineering of proteins by broadening their chemical repertoire. Unfortunately, ncAA incorporation into proteins is limited both by a small collection of orthogonal am...

Fifty Years After Estelle v. Gamble — Where Does Carceral Health Law Go from Here?

Abstract Fifty years ago, the US Supreme Court decided Estelle v. Gamble — a landmark case commonly known for establishing a duty on the government to provide health services to incarcerated people, whether before or after conviction. In this column, we offer a brief critical rea...

Conceptualizing racial inequalities and injustice in social–ecological systems: A foundation for ecology of segregation

Segregation, or social–economic inequity across space, is a widespread phenomenon. What can ecology, with its fundamental concern for spatial heterogeneity, contribute conceptually and practically to issues of segregation? And what can urban ecology learn? The relationships of fo...

Comparison of Actigraphy and Polysomnography in a Sleep Centre Cohort

ABSTRACT Polysomnography (PSG) is the gold standard for sleep assessment, but actigraphy offers a low‐cost, non‐invasive multi‐night alternative. MotionWatch 8 was compared to PSG in a tertiary sleep centre cohort ( n = 107; age 37.6 ± 14.9 years; 56% female), examining whether a...

The role of multisensory integration in child development: Perception, cognition, and action

Multisensory integration (MSI) is a cornerstone of human development, essential for how children perceive, interact with, and understand the world. This review proposes that the developmental trajectory of MSI is characterized by asynchronous maturation of the different sensory s...

Short-term air pollution exposure and hospitalizations in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry

Abstract Rationale While long-term exposure to ambient air pollution in patients with idiopathic pulmonary fibrosis (IPF) has been associated with an increased risk of disease progression and mortality, the risks associated with acute exposure are less clear. Objective To determi...

What primates know about other minds and how often they use it: A computational approach to comparative theory of mind

Can non-human primates (NHPs) represent other minds? Answering this question is difficult because primates can fail tasks due to a lack of motivation or succeed through simpler strategies. Here, we address these challenges through a computational theory-testing framework for NHP...

Baseline cellular state shapes the molecular impact of mutant KRAS alleles in reconstituted pancreatic cancer cells

KRAS is mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC), where hotspot alterations in codons 12, 13, and 61 drive tumor initiation and progression. Although distinct biochemical properties have been described for individual KRAS mutants, whether they generate uniq...

Rapid increase of climate extremes reveals new areas of concern in Amazonia

Abstract Amazonia is highly sensitive to climate extremes, yet we lack an Amazon-wide assessment that examines the spatial-temporal changes in these extreme conditions. We address this within seasons and across the hydrological year, using a quantiles approach that integrates the...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

In Situ Multiscale Imaging Reveals Cellular Selection and Remodeling of Peptide Assemblies from Membrane Perturbation to Actin Dysregulation

Abstract Enzyme-responsive peptide nanomaterials can induce non-apoptotic cancer cell death, yet the supramolecular states that mediate activity in cellular environments are usually inferred rather than directly resolved. Here, we integrate multiscale in situ imaging with biochem...

Sharp cell type boundaries emerge from coordinated morphogen signaling

Classic models of the French flag problem depict sharp cell type boundaries emerging from threshold responses to morphogen gradients. How discrete cell type boundaries arise from morphogen signals that vary continuously across developing tissues remains incompletely understood. W...