Yale University

AI as a partisan cue: the relational dynamics of AI-assisted campaign messaging in election integrity perceptions

This study examines how AI use in campaign messaging shapes voter perceptions of election integrity and how these perceptions vary by partisan identity. Using an online survey experiment with 3,055 US voters randomly assigned to four conditions (plain campaign letter, AI-assisted...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

A Digital Twin Framework for Per-Fraction Prediction of Normal Tissue Toxicity in Radiotherapy of Non-Small Cell Lung Cancer

Background/Objectives: Stereotactic body radiation therapy (SBRT), often delivered in 3–5 fractions, is a highly effective treatment strategy for early-stage non-small cell lung cancer (NSCLC) in medically inoperable patients. Biology-guided radiotherapy (BGRT), a PET-guided SBRT...

From Ionic Agitation to Precision Neuroablation: A Bioengineering Perspective on the Mechanisms, Modalities, and Clinical Applications of Radiofrequency Technology in Pain Management

Radiofrequency ablation (RFA) is a foundational interventional technology in pain management. Despite the diversity of available systems, conventional thermal, internally cooled, bipolar, and pulsed radiofrequency (PRF) all share one biophysical mechanism: high-frequency alternat...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Comparing subsampling strategies for efficient pairwise analysis of large pathogen genomic and spatial datasets: An application to Mycobacterium tuberculosis transmission

Pairwise analysis of genomic and spatial data offers opportunities to identify and estimate the associations between covariates and the transmission of pathogens between individuals. However, such pairwise analyses are computationally intensive, and may not be feasible to conduct...

Agricultural liming is a carbon sink in the Mississippi River Basin

Application of carbonate minerals to arable lands, known as agricultural liming, is a long-standing practice for counteracting soil acidification1–3. Although liming boosts crop yields4, it is also considered a source of agricultural carbon dioxide (CO2) emissions5. Here we show,...

Conceptus attachment coincides with initiation of an anti-inflammatory cytokine profile in the pig endometrium

Abstract Blastocyst implantation is associated with quasi-inflammatory reactions in the endometrium, which are resolved during the establishment of the definitive placenta. Quasi-inflammatory processes have also been documented in pregnant pigs, even though the blastocyst only at...

Interoceptive Accuracy, Metacognition, and Facial Trustworthiness Perception Across the Adult Lifespan

Abstract Older adults often exhibit more positive impressions when forming trustworthiness impressions based on facial appearance. These judgements influence social decisions in later interpersonal interactions and are thought to put older adults at greater risk of victimization....

Association of Habenula Activity and Volume with Pediatric Irritability: Investigation of Inconsistent Parenting as a Moderator

OBJECTIVE: Irritability significantly impacts the mental health and well-being of youth and their families and is associated with adverse concurrent and future outcomes. Brain abnormalities in the reward system are a potential mechanism underlying irritability. However, the haben...

The Iranian Tanzimat: The Global Codification Movement and Legal Reforms in 19th-Century Iran

Abstract This article analyzes reformist treatises from nineteenth-century Iran that called for tanzimat (re-ordering). Central to this reformist discourse was the demand for the enactment of qānūn (modern law). This new conceptualization of law emerged under the influence of Eur...

The nucleoside analog kamuvudine-9 shows protective and therapeutic efficacy in a mouse model of multiple sclerosis

Innate immune signaling through inflammasome activation has been implicated in the pathogenesis of multiple sclerosis (MS). We previously demonstrated that nucleoside reverse transcriptase inhibitors (NRTIs), drugs approved to treat HIV and hepatitis B virus infections, and kamuv...

The anthropogenic fingerprint on emerging infectious diseases

Abstract Emerging infectious diseases are a hallmark of the Anthropocene 1,2 . Human-driven ecosystem changes and human–wildlife–livestock contact can drive the emergence of zoonotic and vector-borne diseases 3–5 , but how much these processes shape landscapes of outbreak risk is...

Multispectral Analysis Graphical User Interface for Ratiometric Analysis and Background Correction

Chemical imaging is a powerful branch of modern microscopy encumbered by a lack of flexible, high‐throughput analysis tools. Bespoke analytical pipelines typically perform ratiometric analysis on two layers in a multispectral image to describe the relative composition of molecule...

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Objectives Apolipoprotein E ε4 ( APOE ε4 ), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathwa...

Non-resonant background response in nonlinear spectroscopy

The non-resonant background is a well-known source of interference in nonlinear spectroscopy. Usually, the non-resonant response is described by a simple amplitude and phase relationship, an often employed approximation that is subject to breakdown in particular limits. To identi...

Fragility of Magic State Distillation under Imperfect Measurements

Magic state distillation (MSD) is the leading approach for producing the non-Clifford resources required for universal fault-tolerant quantum computation. Most prior analyses of MSD assume ideal projective stabilizer measurements, but this assumption becomes questionable on near-...

CONVERGENT GENETIC ARCHITECTURE AND MOLECULAR PATHWAYS UNDERLYING COMORBIDITY BETWEEN OPIOID USE DISORDER AND OTHER PSYCHIATRIC DISORDERS

Background Opioid use disorder (OUD) is frequently comorbid with other neuropsychiatric disorders (NPDs), leading to worsening of both conditions. Despite decades of research, the molecular and genetic mechanisms underlying these comorbid conditions remain largely unclear. Method...

Predicting the Unpredictable: Development and External Validation of the GO SOAR Surgical Risk Calculator for Data-Driven Predictions of Surgical Complications in Gynaecological Oncology Surgery

Background/Objectives: Universal surgical risk calculators are not validated for use and poorly predict postoperative morbidity and mortality for women undergoing gynaecological oncology surgery. This adversely affects communication of risk resulting in poorly informed decisions...

Inscribing chölkha : Census, election, and the making of modern Tibetan diaspora identity

Abstract This article examines the historical formation of modern chölkha identity, a cornerstone of contemporary Tibetan nationalist thought. Rather than a direct continuation of medieval Tibetan identity categories, this article argues that modern chölkha identity is a continge...