Yale University

Burden of Disease in Pediatric Tumor-Induced Osteomalacia: A Literature Review

Tumor-induced osteomalacia (TIO) is an ultra-rare, paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23 (FGF23). In children, TIO may be mistaken for more common causes of rickets and osteomalacia, including monogenic forms, leading to long diagnostic de...

Bankruptcy Prediction from 10-K Narratives: Evidence from Interpretable Text Scores and Accounting Baselines

This study examines whether context-validated acute distress disclosures in annual Form 10-K filings improve bankruptcy-risk ranking beyond accounting variables. The analysis links U.S. Securities and Exchange Commission filing data, Item 7 Management’s Discussion and Analysis te...

Palliative care documentation in gastrointestinal bleeding hospitalizations: national trends and associated care patterns

BACKGROUND: Gastrointestinal bleeding (GIB) often affects older, medically complex patients, yet national patterns of inpatient palliative care documentation in GIB are unknown. We aimed to characterize trends and factors associated with palliative care documentation and examine...

Identification of a key water molecule involved in the macrophage migration inhibitory factor‐catalyzed tautomerization of para ‐hydroxyphenylpyruvate using neutron crystallography

Neutron crystallography was used to determine a 2.5-Å resolution all-atom structure of macrophage migration inhibitory factor (MIF) interacting with 3-(4-hydroxyphenyl)-pyruvate (HPP). MIF is a pro-inflammatory, pro-tumorigenic protein that may be an attractive therapeutic target...

Voters Support and Are Willing to Pay for Local Climate Adaptation Policies

Cities across the United States are increasingly turning to local climate policy as national climate action stalls. Yet, public opinion research on local climate policies remains sparse. I conducted two national surveys ( N = 4,000) measuring respondent willingness to pay (WTP) a...

Projected lives saved and economic value of mRNA cancer immunotherapies in the United States

Messenger RNA (mRNA) technology helped prevent millions of deaths during the COVID-19 pandemic and is emerging as a promising cancer treatment modality. Early-phase trials suggest mRNA immunotherapies can improve overall and recurrence-free survival. However, the U.S. Department...

Gender-affirming psychiatry: a minority stress and phenomenological framework for child and adolescent mental health

This perspective article introduces Gender Affirming Psychiatry (GAP), a conceptual framework that integrates queer phenomenology, the gender minority stress model, and gender-affirming care to guide psychiatric assessment, formulation, and treatment of transgender and gender div...

Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity

Abstract Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present st...

Calr-mediated calcium buffering: a molecular barrier to in vivo cardiac reprogramming

In a recent publication in Cell Stem Cell , Cai et al. 1 employed an in vivo Perturb-seq strategy to systematically identify molecular barriers that limit direct cardiac reprogramming following myocardial infarction (MI). This study provides a conceptual and technological framewo...

Fire as a productive and preventive technology: traditional knowledge and risk governance in Kalunga agropastoral mosaics

Abstract Background Savanna landscapes have returned to the centre of socio-environmental debate as climate variability, agricultural expansion, and prohibition-oriented policies reshape how fire is understood and governed. Focusing on Brazil’s largest maroon (quilombola) territo...

Nickel(I) in an All-FerricNiFeS Cluster

Abstract Anaerobic carbon monoxide dehydrogenase (CODH) enzymes interconvert CO2 and CO under mild conditions and with near perfect selectivity. The CODH active site, termed the C-cluster, is a [NiFe3S4]-Feu cluster that can reside in several different oxidation states. Despite d...

An entangling gate for dual-rail erasure qubits

Quantum error correction (QEC) will likely be required to realize the full potential of quantum computing, but comes with daunting hardware overheads and demands low gate errors on the physical qubits1–4. These requirements can be eased by engineering qubits with a strong error h...

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata , is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to...

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...

Two cases of pregnancy during the fourth year of 68 mg etonogestrel implant use

PURPOSE: The United States Food and Drug Administration recently expanded approval of the 68 mg radiopaque etonogestrel (ENG) contraceptive implant (Nexplanon, Organon, Oss, The Netherlands) from three years to five years, based on clinical trial data showing no pregnancies in ye...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...

A foundation model for sleep-based risk stratification and clinical outcomes

Abstract Clinical sleep studies capture multiple physiologic signals, yet interpretation is often reduced to single summary measures of limited prognostic value, such as the apnea–hypopnea index. We present a foundation model that learns rich representations of sleep physiology f...

Building Climate-Resilient Mediterranean Olive Systems: Integrating Soil, Water, Carbon, Biodiversity, and Innovation for a Sustainable Future

Abstract Mediterranean olive systems face compound climatic, ecological, and socio-economic pressures. Drawing on the consensus of the International Conference on Sustainability in Olive Cultivation (ICSOC) 2025, we propose an integrated framework structured along three axes: fiv...

Uncertainty and Ethical Permissibility in Youth Gender Care

This Viewpoint discusses how misuse of evidence-based medicine displaces the pediatric ethical principles of proportionality and shared decision-making and risks precluding both access to care and generation of evidence needed to reduce uncertainty.

Continuous Glucose Monitoring for Persons With and Without Diabetes

This JAMA Internal Medicine Patient Page describes use of continuous glucose monitors, as well as their benefits and drawbacks.