Yale University

Human claustrum neurons encode uncertainty and prediction errors during aversive learning

Flexible behavior depends on continuous updating of internal models, yet the neural circuits coordinating this process remain poorly understood. The claustrum, which is reciprocally connected to nearly the entire neocortex, is uniquely positioned to influence cortical processing....

Klebsiella pneumoniae from community-acquired infections and an urban river share antimicrobial resistance profiles and high-risk lineages but differ in virulence

Abstract Klebsiella pneumoniae poses a significant public health threat, but the relationship between community-acquired (CA) infections and environmental isolates remains poorly understood. Therefore, this study aimed to assess whether K. pneumoniae from CA infections share micr...

Moving omics methods beyond the bench to tackle urgent challenges facing the water industry

Advances in multi-omic sequencing have revolutionized our understanding of the composition and potential function of genetic sequences across human, natural, and engineered systems. However, while advancements in omics methods have transformed the medical industry through patient...

Low-coercivity and high-resistivity medium-entropy alloy via binder jetting-enabled in-situ carbon doping

The advancement of power electronics demands soft magnetic materials combining magnetic properties with complex-shape manufacturability. Additive manufacturing (AM) offers a route for complex components but is limited by microstructural heterogeneity and residual stress, which de...

Pediatric Patients–Are Sometimes Just Small Adults

The phrase "children are not small adults" has appropriately emphasized the distinct physiological, developmental, pharmacologic, and psychosocial needs of pediatric patients. Yet when educators and health systems convey this message without placing equal emphasis on Pediatric Re...

Recurrent hypermotif regulatory circuits in developmental programs

During development, cells self-organize into complex spatial and temporal patterns driven by regulatory circuits of transcription factors and morphogen signaling. However, the principles that govern these regulatory interactions remain poorly understood. Here, we introduce a fram...

Organizational Factors Impacting Implementation of Evidence-based Practices for Autistic Youth: A Mixed Methods Evaluation of Virginia’s Community Mental Health System

Abstract Despite elevated rates of co-occurring mental health needs among autistic youth, availability of and access to mental and behavioral health evidence-based practices (EBPs) remain limited in U.S. community-based settings. Further, community-based service systems are compl...

A retrospective mixed methods analysis of maternal psychosocial health during the COVID-19 pandemic in Ghana: lessons for future public health crises

Observed impacts of the COVID-19 pandemic in countries in the global north include increasing rates of maternal anxiety and depression. However, little research has been done in sub-Saharan Africa assessing the impact of the pandemic on maternal psychosocial stress. This study ai...

Association of Race/Ethnicity on Resolving Inactive Kidney Transplant Status Prior to COVID-19

Introduction Minority waitlisted kidney patients are less likely to resolve an inactive status change. We investigate race/ethnicity-based differences in the reasons for and resolution of waitlist inactivation. Methods The Organ Procurement and Transplantation Network database wa...

Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer’s disease

Sporadic Alzheimer’s disease (sAD) lacks effective preventive therapies, underscoring the need to target pathogenic drivers. Aberrant calcium signaling is an established early event in sAD pathogenesis that is closely linked to neuroinflammation. Aged rhesus macaques are predomin...

Characterization of chemoresistant cell populations improves risk stratification and therapy prediction in pediatric acute myeloid leukemia

Most pediatric acute myeloid leukemia (pAML) patients achieve complete remission after chemotherapy, yet nearly 40% ultimately relapse and die from their disease. High risk cases are typically referred for stem cell transplantation (SCT) in first remission, but because SCT is ass...

Benjamin Harshav Reads Poems by Yiddish Poet Moyshe Kulbak

Watch here! Published on April 24, 2015 Recorded on March 2, 2015 in North Haven, CT Video editing and English subtitles by Isaac "Itsik" Bleaman Produced for Leyenzal/Forverts.

US Food and Drug Administration Officials’ Public Statements on Regulatory Flexibility in New Drug Approval, 2021–2024

The US Food and Drug Administration (FDA) has historically exercised substantial regulatory flexibility to adjust the type, amount, and quality of evidence necessary to support drug approval for areas of unmet need. Our objective was to characterize how FDA officials described an...

Immune correlates of protection are exposure-dependent: evidence from the Dominican Republic

Immune protection against infection is often treated as a fixed property of a person’s immune response. But infection risk also depends on the number of infectious contacts a person experiences, which generally increases as community transmission rises. This matters for vaccine e...

TESERA: morphologic subtyping and prognostic stratification of hepatocellular carcinoma from H&E whole-slide images

Background & Aims: Hepatocellular carcinoma (HCC) remains among the most lethal cancers worldwide, yet few tools exist to characterize HCC biology and stratify patient risk at the point of care. We developed TESERA (Tissue Encoded Subtype Elucidation and Risk Assessment), a compu...

The Politics of Form of the Hassidic Tale

The main task of this article is to outline a framework of a theory of the politics of the literary form of the Hassidic tale. The point of departure of this theory is that the basic literary form of the Hassidic tale is a narrative of the accomplishment of a magic act that is co...

Mucinous Adenocarcinoma Arising in a Mature Ovarian Teratoma.

Malignant transformation of a mature cystic teratoma (MCT) is rare, with mucinous adenocarcinoma being an even more uncommon subtype. Accurate diagnosis requires distinction from metastatic gastrointestinal tumors. A woman in her 30s presented with a 19 cm right ovarian mass. She...

Screening and Segmenting: A Consumer Surplus Perspective

We analyze consumer surplus when a monopolist can adjust both prices and product qualities across segments, engaging in secondand third-degree price discrimination simultaneously. We characterize the consumer-optimal segmentation and show that it has a striking structure: Consume...

Decreasing Ghost Scanning in Point-of-Care Ultrasound: Impact of a Visual Prompt to Save Images.

BACKGROUND: Ghost scanning, performance of point-of-care ultrasound without image archival, can adversely affect patient care, billing, quality assurance, and result in medicolegal concerns. This study evaluated the Extended Focused Assessment with Sonography in Trauma (eFAST) gh...

Rust’s Type Checker Implementation Is Unsound: An Empirical Study on Soundness Bugs in rustc

Rust is claimed to be a type-sound language capable of preventing various undesirable behaviors, including memory bugs. However, rustc, the official Rust compiler, is not immune to defects; it contains soundness bugs, where the compiler accepts programs that should be rejected du...