Wuhan University

A WOPR transcriptional regulatory network controls the virulence of the opportunistic fungal pathogen Nakaseomyces glabratus

ABSTRACT The WOPR family of transcription factors regulates morphological transitions and virulence in diverse fungal pathogens, yet their roles in Nakaseomyces glabratus —the second leading cause of candidiasis—remain uncharacterized. Through homology searches, we identified two...

Associations of Anatomical Location and Reader Experience With the Diagnostic Performance of Multiparametric MRI ‐Derived VI ‐ RADS for Muscle Invasive Bladder Cancer: A Multicenter Multireader Study

ABSTRACT Background The associations of tumor location and reader experience with Vesical Imaging‐Reporting and Data System (VI‐RADS) performance remain unclear. Purpose To evaluate the associations of tumor location and reader experience with VI‐RADS performance in detecting mus...

Advances in osteoimmunomodulatory biomaterials for periodontal bone regeneration

Abstract Periodontal disease is a highly prevalent chronic inflammatory condition worldwide, significantly impairing patients’ quality of life and imposing a substantial burden on healthcare systems. In recent years, significant progress has been made in the immunopathogenesis of...

Expert knowledge-guided decision calibration for accurate fine-grained tree species classification

Accurate fine-grained tree species classification is critical for forest inventory and biodiversity monitoring. Existing methods predominantly focus on designing complex architectures to fit local data distributions. However, they often overlook the long-tailed distributions and...

Axial behavior of steel tubes strengthened with outer steel tube–concrete jackets

Hollow steel tube (HST) columns are widely used in engineering structures due to their high load-carrying efficiency and excellent ductility. However, strengthening is often required when functional upgrading is needed or when load demands increase. This study investigates the ax...

Wealth-related inequality across the maternal and child continuum of care in low- and middle-income countries: a cross-country panel analysis using the slope index of inequality

Reducing wealth-related inequalities in maternal and child health remains central to universal health coverage (UHC). Prior cross-country analyses have mainly described inequality at single stages of care or relied on simple rich-poor comparisons. Less is known about how country-...

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

ABSTRACT Cardiac hypertrophy is a major pathological response to cardiovascular stress and a critical contributor to heart failure (HF). Gentiopicroside (GPS), a naturally occurring iridoid glycoside derived from Gentiana scabra, exhibits anti‐inflammatory, antioxidant, and anti‐...

Emerging deployment of Engineered Cementitious Composites (ECC) for durable and resilient bridge infrastructure

Abstract Modern bridges are faced with lifecycle challenges of ensuring safety and durability under the combined exposure to traffic and environmental loadings. As an emerging high-performance material, Engineered Cementitious Composites (ECC) possesses ultrahigh tensile ductilit...

Asymmetric epigenetic modifications and transposable elements contribute to subgenome expression dominance in allotetraploid Brassica juncea

Brassica juncea is a widely cultivated and economically important allotetraploid oilseed and vegetable crop. Subgenome expression dominance is a prevalent phenomenon in allopolyploid plants and plays a pivotal role in metabolic regulation, stress responses, environmental adaptati...

Transient phase-based faulty feeder identification for high-impedance faults via autocorrelation entropy difference

In resonant grounding distribution systems (RGDSs), high-impedance faults (HIFs) generate severely attenuated currents and complex arcing behaviors, making faulty feeder identification particularly challenging. Existing magnitude-based methods suffer from significant performance...

Simultaneous temperature and strain monitoring of lithium-ion battery modules using fiber Bragg grating arrays

Lithium-ion batteries are subjected to coupled electrical, thermal, and mechanical stresses during operation, which may lead to significant safety risks. Conventional battery management systems, typically operating at the module level, have difficulty achieving simultaneous cell-...

Preliminary analysis of the materials and production of Shang Dynasty pottery from Zhengzhou Shang City

Zhengzhou City, the capital during the early Shang period, witnessed the Shang Dynasty’s early splendor. This study presents chemical and petrographic analyses of 154 pottery artifacts from the Erligang period, excavated in the Northern Area of Shuyuan Street. The findings reveal...

Epigenetic training licenses naïve CD8 + T cell metabolic fitness and function

Naïve T cells maintain quiescence yet must respond rapidly to antigens, but how they prime this capacity is unclear. We identify histone variant H2A.Z as a key regulator of an epigenetic training program that licenses quiescent naïve CD8 + T cells for future activation. H2A.Z def...

Amine-rich cross-linking templates enabling toughened self-assembled monolayer for stable perovskite solar modules

As the most popular hole-selective materials in efficient p-i-n perovskite solar cells (PSCs), self-assembled monolayers (SAMs) still remain great challenges in long-term stability due to their frail construction and week bonding. To form a toughened donor-acceptor interface, her...

Deciphering Dynamic Self‐Healing for Crystallinity Control in β‐Ketoenamine‐Linked Covalent Organic Frameworks

ABSTRACT Covalent organic frameworks derived from triformylphloroglucinol (Tp‐COFs) represent a prominent branch of COFs due to their high potential in separation, energy storage, and optoelectronics. However, the development of Tp‐COFs is often hindered by limited crystallinity,...

A Random Forest–Based Global Gridded Model for Vertical Correction of Precipitable Water Vapor Accounting for Nonlinear Vertical Variation

Abstract Vertical correction of precipitable water vapor (PWV) is a critical step in PWV fusion and atmospheric research. To address the limited accuracy of traditional global‐scale PWV vertical correction models that do not explicitly account for nonlinear vertical variations, w...

Radiotherapy and immunotherapy for oligometastatic hepatoid adenocarcinoma arising from endometriosis: a case report

Abstract Objectives Hepatoid adenocarcinoma (HAC) arising from endometriosis is an extremely rare malignancy with a poor prognosis and no standard treatment. Radical surgical resection followed by chemotherapy is the commonly used treatment for HAC. The role of radiotherapy and i...

Sketch and paint: A structural–temporal aware refinement network for fine-grained crop mapping on satellite image time series

Crop type mapping based on Satellite Image Time Series (SITS) is a cornerstone of large-scale agricultural monitoring. However, existing methods often struggle in agricultural landscapes characterized by field fragmentation and crop phenological variability, where inter-class bou...

Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

Chronic neuroinflammation and microglial dysfunction lie at the core of Alzheimer’s disease (AD) pathogenesis. The Receptor for Advanced Glycation End-products (RAGE) serves as a pivotal upstream driver of this inflammatory cascade and associated oxidative stress. However, conven...

Early recognition and systemic management of retinal vasculitis in a 15-year-old male

Retinal vasculitis is an inflammatory disorder of the retinal vasculature with diverse etiologies. This case is reported for its relatively uncommon age and distinctive signs, emphasizing the identification of subclinical involvement and the efficacy of early systemic interventio...