Wuhan University

Physiologically Robust Ultralong Aqueous Phosphorescence With Quantitative Hypoxia Sensing Through Hydrophobic‐Hydrophilic Engineering

ABSTRACT Organic room‐temperature phosphorescence (RTP) materials hold great promise as bioimaging agents due to their long‐lived emission and high signal‐to‐background ratios. However, their application in physiological environments is often hampered by water‐induced quenching....

The COACH theory formalizes clinical reasoning in the development and validation of medical artificial intelligence systems

The development and deployment of medical artificial intelligence (AI) systems are limited by two persistent gaps: clinician knowledge is often introduced late in development as labels or annotations, and deployed systems often provide outputs that are difficult to reconcile with...

A Multi-Source Cross-Domain Data Fusion Framework for Ordinal Health-State Assessment: A Reproducible Surrogate Benchmark Motivated by Hydrogen-Cooled Turbogenerators

Real-world fault data for hydrogen-cooled turbogenerators are scarce and largely proprietary, which hinders data-driven health assessment aligned with severity standards. This paper proposes a standards-aligned, multi-source ordinal fusion framework and demonstrates it, as a proo...

Mitral leaflet aneurysm and perforation: healed endocarditis mimicking degenerative valve disease

A 27-year-old male presented with six months of chest tightness, nocturnal diaphoresis, and progressive palpitations. He had no cardiac or rheumatic history; his only prior surgery was a remote hae...

Mechanical responses, failure behaviours and stability of soft–hard interbedded antidip slopes under various degrees of anisotropy

Purpose This study was aimed at investigating the mechanical responses and failure characteristics of soft–hard interbedded rock samples under uniaxial compression and Brazilian splitting tests with varying strength ratios between the hard and soft layers (i.e. anisotropy degrees...

Early-mid Holocene Ross Sea extreme wave heights reflect sea ice retreat and ocean-atmosphere interactions

Abstract Antarctic coastal systems preserve valuable records of postglacial environmental change and extreme storm events. On Inexpressible Island, Ross Sea, we integrated geomorphic mapping, boulder measurements, exposure dating, radiocarbon constraints, and hydrodynamic analysi...

Environmental pollutant UV-328 exacerbates chronic colitis and is associated with altered cholesterol metabolism

Environmental exposure is increasingly recognized as an important contributor to the onset and progression of inflammatory bowel disease (IBD). Although the benzotriazole ultraviolet stabilizer UV-328 is widely present in environmental matrixes and biological samples, and exhibit...

Research on Spatial Equity of Urban Residential Areas and Its Association with Summer Thermal Environment Risk: A Case Study of Wuhan, China

As global warming intensifies and extreme heat events occur frequently, the human thermal environment is under severe threat. In this study, the thermal environment risk and spatial equity issues in residential areas of humid and hot summer cities have become increasingly promine...

MINK1 inhibition suppresses triple-negative breast cancer by abrogating ALDOA S39 phosphorylation and reprogramming glucose metabolism

Triple negative breast cancer (TNBC) represents the most malignant subtype of breast cancer, with heightened invasiveness, frequent recurrence and poor prognosis. Deciphering the molecular mechanisms underlying TNBC pathogenesis and drug resistance is critical for developing prec...

Alternating-chiral charge density waves and associated spin polarization in monolayered NbTe2

Intertwining of different quantum degrees of freedom manifests exotic quantum phenomena in many-body systems, especially in reduced dimensionality. Here we show that monolayered NbTe2 serves as a promising platform where lattice, charge, and spin degrees of freedom manifest coope...

Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles

During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report that conditional deletion of Mdm2, an E3...

Spatiotemporal Sonodynamic‐Nanozymic Therapy for Infected Jawbone Defects

ABSTRACT Infectious jawbone defects, arising from open fractures, surgical contamination, or hematogenous pathogen spread, represent severe orthopedic complications characterized by concurrent bone loss and chronic infection. Precise control of pathogen colonization, effective mo...

Indicator system for regional public health emergency response capacity based on ternary space theory: construction and empirical study in China

Abstract Background Establishing a comprehensive national public health emergency management system is essential for ensuring population health. However, pronounced disparities in economic development and healthcare resources among China’s provinces have led to heterogeneous publ...

Prognostic model for gastric cancer integrating immune biomarkers and machine learning approaches

Prognostication for advanced gastric cancer remains sub-optimal because conventional staging systems overlook systemic inflammation and tumour-immune contexture. We investigated whether incorporating routine immune biomarkers into machine-learning survival models improves risk st...

A partially supervised joint segmentation method for farmland and rural roads from single-class annotated remote sensing datasets

Accurate segmentation of co-existing land-cover objects in high-resolution remote sensing imagery is essential for precision agriculture and rural planning. Although multi-class datasets are increasingly available, many high-quality annotations remain task-specific, where only a...

Prone CT Is Associated With Improved Safety and Stone-Free Outcomes in Prone PCNL: A Propensity-Matched Comparative Study

Purpose: To evaluate whether prone-position computed tomography (CT) is associated with improved perioperative outcomes in patients undergoing prone percutaneous nephrolithotomy (PCNL) compared with conventional supine CT. Patients and Methods: This single-center retrospective st...

The evolving role of TP53 mutation in hepatocellular carcinoma (HCC)

Hepatocellular carcinoma (HCC) is one of the most common cancer types globally, which is characteristically aggressive, with a poor prognosis and a high mortality rate. The pathways leading to the development and progression of this fatal disease have been studied at the macro an...