Wuhan University

Adjunctive n-3 PUFA supplementation improves niacin skin flush response and shows biomarker-stratified signals in schizophrenia

BACKGROUND: Findings regarding the efficacy of n-3 polyunsaturated fatty acid (PUFA) supplementation as an adjunct treatment for schizophrenia (SZ) have been inconsistent. This study investigated whether n-3 PUFA supplementation was associated with changes in niacin skin flush re...

Semantic Segmentation for 3D Point Clouds with Curvature-Aware Sampling and Inverse-Density Weighting

Point cloud classification and part segmentation require effective downsampling methods that reduce computational cost while preserving object boundaries, thin structures, and other informative geometric regions. However, raw point clouds are often large, irregular, and non-unifo...

The Risk Spillover Within a Financial System: Evidence from China

In this paper, by proposing a new risk measure called CoRVaR, we explore the risk spillover effect within a financial system consisting of the banking, security and insurance industries. To be precise, we examine the risk spillover effect from each industry to the other. Moreover...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Museum lighting strategies for sculptural non-photosensitive exhibits: the role of bottom illumination and optimal CCT

Lighting design is a key component of indoor museum environments, influencing both object visibility and viewers’ visual experience. However, existing studies have mainly focused on planar artworks or general interior lighting, while three-dimensional, non-photosensitive ceramic...

Odometry and Mapping for Complex Environment Perception Under Partial-View Sensing

Dense partial-view LiDAR observations are attractive for outdoor perception, but limited overlap and viewpoint sensitivity make odometry and mapping less reliable than with spinning LiDARs. Many recent algorithms for this sensing regime are built as LiDAR-inertial odometry framew...

RNA-Binding Protein MBNL2 Drives Cardiac Hypertrophy and Dysfunction by Facilitating TPM3 Splicing

BACKGROUND: Cardiac hypertrophy is a major contributor to heart failure development, making its prevention and treatment critical for reducing heart failure–associated mortality. Although alternative splicing is recognized as a key regulatory mechanism in myocardial hypertrophy,...

Experiences of social participation and inclusion among primary caregivers of children with cerebral palsy in China: a qualitative descriptive study

Primary caregivers of children with cerebral palsy (CP) may experience challenges affecting their social participation and inclusion. However, these experiences remain insufficiently understood in the Chinese context. Understanding these experiences is important for family-centre...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long‐Term Stability

ABSTRACT The dense packing of cells within tissues poses challenges for studying cellular properties. Sparse labeling, genetically targeting a small subset of densely distributed cells, provides a powerful approach to investigate cellular morphology, connectivity, dynamics, and f...

SLC7A11-associated astrocyte states are linked to redox imbalance and synaptic microenvironment remodeling in multiple sclerosis: translational implications

Abstract Background Multiple sclerosis (MS) is characterized by inflammatory demyelination, oxidative stress, and neurological dysfunction. Despite disease-modifying therapies, chronic active lesions and ongoing neurodegeneration remain largely untreated, highlighting the need fo...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dent...

Serum miR-378d is associated with liver stiffness and fibrosis risk in patients with metabolic dysfunction-associated steatotic liver disease

Tissue biopsy is the gold standard for diagnosing metabolic dysfunction-associated steatohepatitis (MASH), but it is invasive and time-consuming to analyze. This paper aimed to explore the association between serum miR-378d and liver stiffness and fibrosis risk in patients with m...

Classifications of Substorms With MLT Patterns of SMU‐SML Indices Based on Convection Properties

Abstract During substorms, magnetospheric convection and magnetotail current sheet disturbances are two critical processes, both driving ionospheric electrojets. Dusk‐side SMU and dawn‐side SML (SuperMAG Electrojet indices) enhancements reflect two‐cell convection. Using this rel...

Integrated O 2 and H 2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

ABSTRACT Impaired wound healing in diabetes is closely associated with cellular ferroptosis. Microneedle‐assisted gas therapy exerts molecular regulation of ferroptosis, representing a promising approach for accelerating diabetic wound healing. To date, O 2 and H 2 gas therapies...

MRIo3DS-Net: a mutually reinforcing images to 3D surface RNN-like framework for model-adaptation indoor 3D reconstruction

Currently, deep neural networks (DNNs) have made some progresses in local region feature extraction, image matching under difficult conditions and point cloud surface optimization in photogrammetry and computer vision. However, there have been being no reports on an end-to-end hi...

Identification of Ferro‐Aging‐Related Biomarkers for Ulcerative Colitis Through Integrated Machine Learning, Single‐Cell Analysis, and Spatial Transcriptomics

Ulcerative colitis (UC) is characterized by chronic mucosal inflammation, epithelial injury, oxidative stress, and marked molecular heterogeneity. Ferro-aging has recently been proposed as an ACSL4-associated, iron-dependent aging-related state in primates, but whether its associ...

Escalating Uncertainty Under Increasing Risk in Compound Heat and Precipitation Extremes

Abstract Projection uncertainty fundamentally constrains climate adaptation, yet its evolution in compound heat and precipitation extremes (CHPE) remains poorly understood. Here we quantify CHPE uncertainty using 14 CMIP6 models and two single‐model initial‐condition large ensemb...

A Coupled LBM‐FDEM Framework for Simulating Solute Transport and Mineral Dissolution Under H‐M‐C Conditions

Abstract The injection of CO 2 into geological reservoirs can acidify the reservoir environment, leading to the dissolution of mineral grains and increasing the risk of CO 2 leakage. A deeper understanding of these micro‐scale dissolution mechanisms is therefore essential for the...