Wuhan University

Cardiac fibroblast-derived GNL3 aggravates acute doxorubicin-induced cardiac injury via FasL-linked fibroblast–cardiomyocyte crosstalk

Doxorubicin (DOX)-induced cardiac injury remains a major clinical challenge in oncology, with limited preventive strategies beyond dexrazoxane. Although cardiomyocyte-centered mechanisms dominate current understanding, the contribution of cardiac fibroblasts (CFs) remains incompl...

Constraining Annual Coal Mine Methane Emissions with Multitemporal Hyperspectral Satellite Observations

Abstract Methane emissions from coal mining are difficult to constrain because of temporal variability and sparse observations. We used multitemporal hyperspectral observations from GF5A, GF5B, ZY1E, and ZY1F to quantify facility-scale emissions and evaluate sampling requirements...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Design of Iron-Based Fischer–Tropsch Synthesis Catalysts for Directly Converting Syngas to Value-Added Chemicals and Clean Fuels

Conspectus Fischer–Tropsch synthesis (FTS) represents a key technology for converting syngas into fuels and value-added chemicals. Despite decades of industrial application, it remains constrained by three persistent challenges: the dynamic reconstruction of active phases under w...

Core-shell Au@HOF nanoradiosensitizers activate potent immunogenic cell death for enhanced radio–radiodynamic–immunotherapy

Radiotherapy (RT) efficacy is constrained by inefficient radiation utilization and inadequate systemic immunity. Although nanoparticle-based radiosensitizers aim to enhance therapeutic outcomes, most existing systems lack effective integration of radiation enhancement, dynamic th...

User engagement behaviours with identity-disclosed social bots on social media: the role of perceived human–machine differences

Purpose This study examines how users interpret identity-disclosed social bots on social media, how perceived human–machine differences shape psychological response orientations and how these orientations are enacted through visible engagement behaviours. Design/methodology/appro...

Bulk 1T-NbSe2 Superconductor Stabilized by the Doped Ti-3d0 Electronic Configuration

Abstract Metastable 1T-phase transition-metal dichalcogenides host rich strongly correlated electronic phenomena, yet the synthesis of bulk 1T-NbSe2 remains a challenge. This difficulty stems from the energetic penalty associated with the octahedral coordination of Nb4+, whose 4d...

Therapeutic targeting of the SLC39A13-AS1/TCF20/RUNX1 axis inhibits glutamine metabolism and ovarian cancer progression

“Glutamine addiction” is among the key features of tumor metabolic reprogramming and is an important target for tumor therapy. Unfortunately, the mechanisms underlying the abnormal expression of genes related to glutamine metabolism in ovarian cancer (OC) remain unclear. Here, we...

Machine Learning-Guided Strategy Selection and Condition Prediction for Photoredox Catalysis

Abstract Photoredox catalysis offers powerful opportunities for organic synthesis, yet its broader application remains limited by the difficulty of identifying viable synthetic routines and conditions. Here, we present an experimentally validated, machine-learning-assisted workfl...

Robust Quasi-Continuous-Wave Exciton–Polariton Lasing in Tin Halide Perovskite Nanowires under Ambient Conditions

Abstract Tin halide perovskites are promising lead-free optical gain media, yet stable quasi-continuous-wave/continuous-wave (quasi-CW/CW) lasing remains challenging under practical operating conditions. Here, we demonstrate robust quasi-CW lasing from single-crystalline CsSnBr3...

Breviscapine attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis via activation of NRF2/SLC7A11/GPX4 pathway

To explore the protective effect of Breviscapine against myocardial ischemia-reperfusion (I/R) injury and its mechanism. The in vivo and in vitro models of myocardial I/R injury were first established and treated with different concentrations of Bre. The myocardial infarct size w...

Sigma-1 receptor protects against renal ischemia-reperfusion injury by enhancing mitophagy via Rac1 regulation

Renal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury, associated with mitochondrial dysfunction, excessive reactive oxygen species (ROS) production, and tubular cell apoptosis. The Sigma-1 receptor (Sigma1R), an intracellular chaperone, plays a crucia...

Biotactic Nanodrugs Induce Tumor‐Localized and Durable Embolization via Programmatic Participation in Physiological Biochemical Reactions

The clinical application of tumor vascular obstruction therapy (TVOT) is mainly hindered by imprecise obstruction localization and transient embolic effects. We developed a biotactic nanodrug termed PDA-A@Fib to achieve precise and sustained TVOT by programmatically participating...

A novel FUT1 mutation c.268G>A ( p.Gly90Ser ) associated with the para‐Bombay B blood phenotype

The authors have disclosed no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Mineralogical Heterogeneity Controls Dissolution-Front Instability and Reactive-Transport Scaling in Porous Media

Abstract Mineral dissolution in multicomponent porous media involves coupled mineral–water reactions, solute transport, and evolving pore topology. However, most continuum reactive-transport models still rely on constitutive relations developed for single-mineral media, and the i...

Advances in osteoimmunomodulatory biomaterials for periodontal bone regeneration

Abstract Periodontal disease is a highly prevalent chronic inflammatory condition worldwide, significantly impairing patients’ quality of life and imposing a substantial burden on healthcare systems. In recent years, significant progress has been made in the immunopathogenesis of...

MicroRNA-2110 acts as a tumor suppressor in gastric cancer via direct targeting of IGF1R

Abstract Background MicroRNA-2110 has been implicated in cancer, but its expression and function in gastric cancer (GC) remain understudied. This study aims to explore the role of miR-2110 in GC and its regulation of IGF1R. Methods RT-qPCR was used to measure miR-2110, IGF1R expr...

Attack Chain Reconstruction Method Based on LLM Prior-Knowledge Guidance and Heterogeneous Graph Reasoning

In the face of multi-stage and cross-device complex network attacks, reconstructing the complete attack link from massive heterogeneous security logs is the core problem of security operation. In the existing methods, the traditional graph model lacks a deep understanding of the...

Novel mTORC1 Booster LAPTM4A Potentiates Pathological Cardiac Hypertrophy

BACKGROUND: Excessive unnecessary protein accumulation in cardiomyocyte is a leading contributor for pathological cardiac hypertrophy and has been found closely regulated by the mTORC1 (mechanistic target of rapamycin complex 1) signaling and lysosome transmembrane proteins. Howe...

A WOPR transcriptional regulatory network controls the virulence of the opportunistic fungal pathogen Nakaseomyces glabratus

ABSTRACT The WOPR family of transcription factors regulates morphological transitions and virulence in diverse fungal pathogens, yet their roles in Nakaseomyces glabratus —the second leading cause of candidiasis—remain uncharacterized. Through homology searches, we identified two...