Wuhan University

High-frequency Earth rotation parameters estimated from VLBI observations during CONT campaigns

The Desai–Sibois high-frequency Earth rotation parameter (HF-ERP) model provides one of the most detailed descriptions of diurnal and sub-diurnal variability up to date. However, it still underrepresents short-period signals, underscoring the need for reliable, observation-based...

Global existence of axisymmetric solutions to 2D relativistic stiff fluid equations

We prove global-in-time existence of smooth axisymmetric solutions to the 2d relativistic Euler equations for stiff matter, which admits linearly degenerate characteristics. By exploiting the decoupling property between the vorticity and the sound wave in the domain containing th...

Porcine Sertoli cell exosomes tune the redox setpoint of spermatogonial stem cells through PSMD11–p38 MAPK signaling to mediate differentiation

Spermatogonial stem cell (SSC) fate—the choice between self-renewal and differentiation—is governed by intercellular signaling within the testicular niche. A central paradigm holds that endogenous reactive oxygen species (ROS) sustain SSC self-renewal through MAPK signaling. Yet...

Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

Chronic neuroinflammation and microglial dysfunction lie at the core of Alzheimer’s disease (AD) pathogenesis. The Receptor for Advanced Glycation End-products (RAGE) serves as a pivotal upstream driver of this inflammatory cascade and associated oxidative stress. However, conven...

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

Abstract Postoperative recurrence remains a critical challenge in cancer management, necessitating innovative strategies to reshape the tumor microenvironment (TME) and enhance immune surveillance. This review highlights nanomedicine‐driven breakthroughs in postoperative immunoth...

Convergent use of aminopeptidase N receptor by hedgehog merbecoviruses

Abstract Coronaviruses circulating in wildlife, such as European and Asian hedgehog merbecoviruses (EriCoVs), pose a potential transmission risk. Knowledge of viral receptors can inform risk assessment and development of countermeasures; however, the functional receptor for EriCo...

Centralized Land Supply Policy and Carbon Emissions Reduction of Listed Companies: A Green Back-Pressure Mechanism Under Land Fiscal Constraints

This paper treats the “Two Centralizations” policy for residential land supply in 22 key cities introduced by China’s Ministry of Natural Resources in 2021 as a quasi-natural experiment. Based on data of A-share non-financial listed companies from 2013 to 2023, we adopt the Diffe...

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (R...

Pulmonary artery catheter trials in cardiac surgery and haemodynamic decision states

Perry et al. show that allocating low-risk cardiac surgical patients randomly to pulmonary artery catheter or central venous catheter monitoring is feasible [1]. The near absence of crossover, low clinician refusal and near-complete follow-up are useful because device preference...

High-resolution land cover mapping from coarse labels via a noisy label learning-guided cross-scale framework

High-resolution remote sensing images (HRSIs) provide essential data support for land cover mapping, where deep learning has shown great promise. However, deep learning-based methods rely on abundant high-quality annotations, while low-resolution coarse labels are difficult to us...

Library strategies differentially shape microbial, functional, and host signals in clinical metagenomic sequencing

Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel...

Willingness to use long-acting injectable HIV pre-exposure prophylaxis (PrEP) among men who have sex with men: A meta-analysis

Background Men who have sex with men (MSM) face a high risk of HIV acquisition globally. Oral pre-exposure prophylaxis (PrEP) is effective but limited by adherence and stigma. Long-acting injectable PrEP (LAI-PrEP) offers a promising alternative, yet global acceptance among MSM r...

REDD1 Silencing Aggravates Aortic Dissection and Promotes VSMC Apoptosis with Autophagy-Related Changes

Background: Aortic dissection (AD) is a life-threatening vascular disease with high mortality, yet its molecular pathogenesis remains incompletely understood. This study investigated the role of regulated in development and DNA damage responses 1 (REDD1) in vascular smooth muscle...

Kinetic Regulation of Intercalation-Assisted Crystallization in Hybrid Evaporation–Solution Perovskite Solar Cells

Abstract Hybrid evaporation–solution processing offers a promising route for high-efficiency perovskite solar cells; however, the dense lead iodide (PbI2) framework leads to competing intercalation and dissolution–recrystallization pathways, resulting in incomplete conversion and...

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Abstract Background Gallstones affect approximately 6%–15% of adults worldwide and represent a common condition that also serves as a risk factor for hepatobiliary malignancies. Conventional ultrasound cannot provide early warning during the early metabolic phase before crystalli...

Longitudinal Study on Post‐Traumatic Stress Disorder, Anxiety, and Depression Among Medical Staff in China

ABSTRACT Background Evidence of the longitudinal relationship between anxiety, depression, and post‐traumatic stress disorder (PTSD) is not uniform. This study aimed to explore the dynamic changes, independent factors, and bidirectional predictive relationships of anxiety, depres...

Field‐Aligned Anisotropy of Electrons in Magnetic Hole Behind the Dipolarization Front in the Flow Braking Region

Abstract Magnetic holes (MHs) are magnetic structures characterized by a depression of magnetic field strength and have been frequently observed around dipolarization fronts (DFs), which are characterized by the increase in the magnetic field B z . Both MHs and DFs are potential...

Combined effects of ceramic polishing powder and GGBS on microstructure and freeze–thaw performance of concrete

The concrete industry faces dual challenges of high carbon emissions and large-scale accumulation of industrial solid wastes, particularly in cold regions where freeze–thaw damage significantly reduces structural durability. This study investigates the combined use of ceramic pol...

CO-Mediated Relay Catalysis Affords Selective CO2 Hydrogenation to Methanol

Abstract Although technologically promising for producing petrochemicals directly from renewable resources, CO2 hydrogenation to methanol remains a formidable challenge due to the activity-selectivity trade-off. Current industrial copper-based catalysts often generate substantial...

Sandwiched thermal management system combining topology-optimized liquid channels and phase-change materials for cylindrical Li-ion batteries

To address lithium-ion battery thermal management challenges under extreme high-rate discharging (5C constant-current, initial ambient temperature of 298.15 K), this study proposes a sandwiched 3D composite system. It integrates a topology-optimized cold plate with phase change m...