Institution
Wuhan University
Recent research
- BiologyOpen access
Cognitive impairment in schizophrenia is inadequately treated. The molecular link between oxidative stress and neuroinflammation in its pathophysiology remains unclear. We measured CB2R in circulating microglia‑derived exosomes from schizophrenia patients and healthy controls. In...
- BiologyOpen access
ABSTRACT Ischemia/reperfusion (I/R)‐induced acute lung injury (ALI) is a severe clinical syndrome characterized by alveolar epithelial damage, oxidative stress, and acute respiratory failure, but the epitranscriptomic mechanisms linking N6‐methyladenosine (m6A) modification to fe...
- Health & MedicineOpen access
Targeted next-generation sequencing (tNGS) is increasingly used for pathogen detection in lower respiratory tract infections. However, real-world data on bronchoalveolar lavage fluid (BALF)-dominant tNGS findings in respiratory and critical care settings remain limited. This sing...
- Materials & EnergyOpen access
ABSTRACT Electrosynthesis of hydrogen peroxide (H 2 O 2 ) via the two‐electron oxygen reduction reaction (2e − ORR) offers a sustainable and decentralized alternative to the anthraquinone process. However, conventional solo‐active‐site catalysts are intrinsically limited by scali...
- BiologyOpen access
Abstract Background Urinary cell-free DNA (ucfDNA) holds promise for liquid biopsies, yet standardized preprocessing protocols are lacking. This study evaluated the impact of several preanalytical variables on ucfDNA quality: ethylenediaminetetraacetic acid (EDTA) concentration,...
- Health & Medicine
ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people wi...
- Society & EconomicsOpen access
Urban energy transition requires the deployment of clean energy alongside technologies that lower the carbon intensity of urban economic activity. Yet the effect of climate-smart technology may change with the stage of technology diffusion. Using city-level data from 282 Chinese...
- BiologyOpen access
Integrating global crop models with knowledge graphs: Evolution, comparison, and future directions
Crop models leverage mathematical methods to simulate plant growth and environmental responses, forming a powerful and critical tool for agricultural decision support in research, management, and policy–making. However, a comprehensive review that systematically integrates global...
- Health & Medicine
BACKGROUND: Available data indicate that people living with HIV (PLWH) have weaker humoral immune responses to COVID-19 vaccines compared to the general population. However, data on cellular immune responses in this group has yet to be established. METHODS: We searched the PubMed...
- Biology
Aims: Oxidative stress–driven cardiac remodeling is a key pathological feature of heart failure and hypertensive heart disease, yet effective antioxidant therapies remain limited. This study aimed to determine whether the natural dihydrochalcone trilobatin (Tri) protects against...
- BiologyOpen access
A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...
- BiologyOpen access
Applications of artificial intelligence in the analysis of alveolar clefts: a scoping review
Background Alveolar clefts are a prevalent clinical manifestation of cleft lip and palate (CLP), and are typically managed with secondary alveolar bone grafting (SABG) during mixed dentition. Nonetheless, considerable variability in the morphology and volume of the defect influen...
- Climate & EnvironmentOpen access
Recent globally synchronous seasonal warm events unprecedented since 850 CE
Spatially synchronous extreme warm events can amplify environmental and societal impacts by affecting multiple regions simultaneously. However, previous studies have largely focused on June–August (JJA) events during the instrumental period, limiting understanding of their season...
- AI & ComputingOpen access
Signal Temporal Logic (STL) is a formal language for specifying real-time behaviors of cyber-physical systems (CPS). Automatically transforming natural language requirements into STL specifications has received growing attention. Recent efforts leveraging large language models (L...
- BiologyOpen access
Abstract Dysregulation of long non-coding RNAs (lncRNAs) plays a significant role in the progression of hepatocellular carcinoma (HCC), yet many underlying mechanisms remain elusive. Recent studies have highlighted the critical importance of internal N 7 -methylguanosine (m 7 G)...
- Materials & EnergyOpen access
Mechanical scratches that penetrate the protective layers expose the steel substrate and establish a zinc–steel galvanic couple beneath an electrolyte film. This study develops a mechanism-oriented multiphysics model of scratch-width-dependent galvanic protection loss in hot-dip...
- Physics & SpaceOpen access
Abstract Extreme positive cloud‐to‐ground lightning over East Asian midlatitudes exhibits a spring–autumn double maximum hidden by the familiar winter climatology. Using 1,838,538 return strokes with absolute peak currents at least 200 kA during 2006–2024, we resolve its annual c...
- Health & MedicineOpen access
The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023
Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...
- Materials & Energy
ABSTRACT Aqueous sulfur electrochemistry holds great promise for high‐energy density storage but is currently constrained by sluggish redox kinetics and severe polarization. Despite extensive efforts in catalyst design to enhance polysulfide adsorption, kinetic improvements have...
- BiologyOpen access
CoxFormer enables spatial omics inference with multimodal generative modeling
Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overco...