Wuhan University

Individualized hybrid electroconvulsive therapy (i-HECT) shows rapid anti-depressant effect in young patients with depression

Abstract Background For young patients with depression, electroconvulsive therapy (ECT) is highly effective but causes acute cognitive side effects. We designed a new individualized hybrid electroconvulsive therapy (i-HECT) combines ECT with low-charge electrotherapy (LCE) and in...

Using earth observation for national high resolution dynamic material stock modelling through time; assessing sand consumption in Malaysia from 1989 to 2020

Abstract Understanding the spatio-temporal dynamics of volumes of construction materials is becoming crucial for environmental sustainability and achieving long-term development goals. Whilst direct data collection is always the preferable option it is not always practical. This...

Computationally Efficient Robust Information Filtering for In-Flight GNSS/SINS Tightly Coupled Navigation with High-Dimensional Observations on Small UAVs

The full operation of BDS-3 enables users to obtain high-performance positioning services, benefiting from the surge in the number of Global Navigation Satellite System (GNSS) observations with multi-constellation multi-frequency signals. This overabundance is beneficial to impro...

Biomass-Derived Cooperative Pyridinic/Pyrrolic-N Sites Enable Efficient Metal-Free N-Alkylation of Alcohols with Amines

Abstract N-alkylamines serve as essential structural units in pharmaceuticals, agrochemicals, bioactive molecules, etc. Nevertheless, their conventional syntheses predominantly rely on metal-based catalysts, which frequently encounter challenges including metal leaching, easy poi...

Pathways to clinician-scientist identity among medical PhD candidates: a multi-case ideal-typical analysis

<title>Abstract</title> <bold>Background</bold> : Clinician-scientists are widely regarded as critical for translational medicine, yet many systems struggle to sustain a stable clinician-scientist workforce. Existing research often assumes a single linear identity pipeline and fo...

Embedded Fishbone Foreign Bodies in the Tongue: Clinical Characteristics and Treatment Strategies: A Retrospective Study

BACKGROUND: Lingual fishbone foreign bodies completely embedded in the deep lingual musculature present significant surgical challenges due to imprecise preoperative localization and the risk of iatrogenic injury to neurovascular structures. However, the current literature on thi...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

Reliable Battery-free Backscatter Video Transmission for Ubiquitous Vision-based Sensing

Past decades have witnessed the rapid development of battery-free backscatter-based cameras, opening up promising long-term and sustainable surveillance applications by harvesting wireless energy. However, limited by the fluctuations of the ambient energy, existing backscatter sy...

m6A ‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

ABSTRACT Background Ferroptosis is a non‐apoptotic form of cell death driven by lipid peroxidation. Although elevated lipid peroxidation has been linked to respiratory epithelial injury, its role in allergic rhinitis (AR) remains unclear. Therefore, in this study, we aimed to ass...

In-Situ Growth of Bimetallic ZnCo-ZIF-67 on Carbon Fibers as High-Efficiency Catalyst for Enhancing Thermal Decomposition of Ammonium Perchlorate

Due to its abundant active sites, the bimetallic zeolite imidazole framework ZnCo-ZIF-67 exhibits excellent catalytic performance on the key oxidant ammonium perchlorate in composite solid propellants. In addition, carbon fiber has been proven to promote the combustion of propell...

Associations of outdoor artificial light at night with type 2 diabetes and metabolic syndrome among Chinese adults

This study investigated the associations between outdoor artificial light at night (ALAN) and type 2 diabetes (T2DM) and metabolic syndrome (MetS) and aimed to characterize the dose-response relationships and potential exposure thresholds. This cross-sectional study included 57,8...

Short-Term Electric Vehicle Charging Load Forecasting Based on Sample Entropy and CEEMDAN-TCN-BiGRU Hybrid Model

The large-scale integration of electric vehicles (EVs) brings significant challenges to power grid operation due to the strong nonlinearity and non-stationarity of charging loads. To address the limitations of existing methods in noise suppression and temporal feature extraction,...

Counterintuitive Temperature-Dependent Interfacial Thermal Resistance in Twisted van der Waals Interfaces

Precise control of interfacial thermal resistance (ITR) is essential for thermal management in van der Waals (vdW) devices. Here, we report a counterintuitive temperature-dependent reversal of ITR in twisted PtX2 (X = S, Se, Te) interfaces. At near-commensurate small twist angles...

Work Together With One Heart: Enterprise Digitization and Green Innovation of Supply Chains Collaboration

ABSTRACT Against intensifying market competition, supply chain green collaborative innovation (SCGCI) has evolved into a vital strategic option through which firms reduce operating costs, enhance firm value, and alleviate financing constraints, while digital transformation has be...

Global cloud phase monitoring from FY-3G multi-angle polarimetric observations using the new MAPLE-CP framework with independent multi-site lidar validation

Global cloud-top phase monitoring is constrained by an observing gap: passive imagers provide broad coverage but limited vertical phase information, whereas active sensors provide stronger physical constraints only along narrow tracks. Here we develop MAPLE-CP, a Multi-Angle Pola...

SiCl4-Assisted Calcination Strategy for Lithium Recovery and Regeneration of Cathodes

Abstract The rapid growth of lithium-ion battery (LIB) deployment has intensified the need for efficient and sustainable recycling of spent cathodes. This work introduces a silicon tetrachloride (SiCl4)-assisted calcination strategy that repurposes SiCl4, a hazardous byproduct of...

Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK from Pseudomonas aeruginosa

Resistance–nodulation–cell division (RND) efflux pumps are the major cause of multidrug resistance in Pseudomonas aeruginosa . The inner membrane protein MexK from P. aeruginosa is a narrow-spectrum RND transporter. It assembles with membrane fusion protein MexJ and outer membran...

Study on the Power‐Frequency Arc Extinction Characteristics of Semi‐Closed Short‐Gap Device

ABSTRACT Multi‐chamber arc‐extinguishing devices have a simple structure and excellent arc‐extinguishing performance; thus, they have attracted considerable attention as lightning protection devices. However, the structural parameters of different models of the aforementioned dev...

Atomic-scale engineering of Pt shells on chiral Au nanoparticles for enhanced oxygen reduction

Spin selection in chiral nanocatalysts enabled by the chiral-induced spin polarization (CISS) effect has emerged as a promising strategy for boosting the performance of the oxygen reduction reaction (ORR). However, achieving atomic-scale control of catalytically active surfaces o...

Acoustic higher-order topological metals with bound corner states in the continuum

Two-dimensional topological insulators for first order and higher order, characterized respectively by in-gap edge states and corner states, have attracted tremendous research interest. Different from them, two-dimensional topological metals exhibit topological boundary states in...