University of Toronto

Why Integration Compounds A Threshold Theory of Technology Transfer and Global Value Chains

The returns to integration into global value chains split by level of development: integration raises productivity and growth in emerging and faster-growing economies, but not in slower-growing developing ones. The split is established, but no formal model accounts for its conseq...

Real-World Shelf Life of Epinephrine Auto-Injectors in Canada: Implications for Renewal Frequency and Patient Burden

Although patients in Canada at risk of anaphylaxis are recommended to maintain access to two in-date epinephrine auto-injectors (EAIs) at all times, underuse during emergencies remains common. Multiple factors contribute to this gap, but the impact of real-world shelf life has be...

Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects

Background/Objectives: Telerehabilitation may extend neurorehabilitation beyond conventional settings, but comparative effects across neurological diagnoses and motor domains remain uncertain. This systematic review and meta-analysis synthesized motor outcomes while distinguishin...

Muometric Data Modulation and State Synchronization Through Obstructed Subsurface Media: A Theoretical Framework, Channel Physics Model, and Protocol Design

Conventional radio-frequency (RF) and acoustic communication channels suffer severe absorption and scattering when traversing dense rock and collapsed subsurface infrastructure [4, 5]. While relativistic muons (µ ±) possess extreme penetration capabilities, their application as p...

Muometric Data Modulation and State Synchronization Through Obstructed Subsurface Media: A Theoretical Framework, Channel Physics Model, and Protocol Design

Conventional radio-frequency (RF) and acoustic communication channels suffer severe absorption and scattering when traversing dense rock and collapsed subsurface infrastructure [4, 5]. While relativistic muons (µ ±) possess extreme penetration capabilities, their application as p...

Evidence-Based Insights for the Development and Talent Promotion of Young Athletes in a National Sports Context

Abstract The development of young athletes continues to be a key concern for sports organizations, coaches and policy makers. In Sweden, the public debate on the balance between early talent promotion programs and more inclusive, long-term athlete development models has recently...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Balancing data quality and participant burden: a comparative analysis of abbreviated vs extended symptom diaries in the CanTreatCOVID trial

Abstract Background Symptom diaries are widely used in acute respiratory infection trials to capture patient-reported symptom severity and recovery. Longer questionnaires may provide a more complete clinical picture but can increase participant burden and reduce adherence. Eviden...

Pharmacological Management of Opioid Use Disorder: A Systematic Review and Network Meta-Analysis: Prise en charge pharmacologique du trouble de l'usage des opiacés : revue systématique et méta-analyse en réseau

Objective To assess the comparative benefits and harms of opioid substitution and antagonist therapies (OSATs) for opioid use disorder (OUD) using a network meta-analysis (NMA) of randomized controlled trials (RCTs). Data Sources Medline, EMBASE, PubMed, PsycINFO, Web of Science,...

Sex & Gender Science: integrating the social with the biological

Abstract For decades, researchers have largely studied aspects of sex and gender separately; the former as a basic science and the latter as a social construct with real world consequences, including health inequities. In recent years, as our collective understanding of how the b...

How do different phonics programs support word decoding? Insights from computational analyses

Abstract Phonics instruction involves teaching grapheme-phoneme correspondences (GPCs) and is widely recognized as an effective method of reading instruction. We examined what GPCs phonics programs teach, how those GPCs support a child’s ability to pronounce written words to unde...

Presence of asymptomatic lesions in myelin oligodendrocyte glycoprotein antibody-associated disease and neuromyelitis optica spectrum disorder: a retrospective study

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD) can present with asymptomatic lesions in the absence of corresponding clinical symptoms. These lesions may represent inter-attack subclinical disease activit...

Estimating dynamic soft continuum robot states from boundaries

State estimation is one of the fundamental problems in robotics. For soft continuum robots, this task is particularly challenging because their states (poses, strains, internal wrenches, and velocities) are inherently infinite - dimensional due to continuous deformability, while...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Leveraging prompt-driven generative AI for systematic reviews in digital psychiatry: A stage-matched comparative proof-of-concept for healthcare researchers and clinicians

The scale and pace of evidence generation in digital psychiatry increasingly exceed the capacity of traditional systematic literature review (SLR) methods. Large language models (LLMs) are gaining traction in evidence synthesis, yet limited guidance exists for integrating generat...

Ecological performance of cultivated and feral populations of an invasive freshwater fish under current and near-future climatic conditions

Goldfish (Carassius auratus), a globally invasive species, is increasing in abundance in lakes and ponds within the Laurentian Great Lakes region. We hypothesized that current and future selection pressures imposed on feral goldfish populations adapted to urban and natural ponds...

Psilocybin

This JAMA Insights discusses the medical use of psilocybin, particularly for depression treatment, including emerging potential indications, safety, and future use.

Extensive and differential platinum chemotherapy mutagenesis in livers of children

Childhood cancer survivors often experience late adverse effects that may be linked to chemotherapy mutagenesis. We studied chemotherapy mutagenesis in normal pediatric tissues using duplex sequencing (NanoSeq) to enable the detection of mutations from single DNA molecules. We fo...

Implementation and evaluation of a technical support center for the Research to Enhance the Adaptation and Implementation of Health Systems Guidelines in LMICs [RAISE] initiative

Abstract Background Capacity-strengthening initiatives for health policy and systems research (HPSR) in low- and middle- income countries (LMICs) are often designed with little consideration of LMIC stakeholder needs. We formed a Technical Support Centre to support research teams...

Motivational profiles and exercise in late adolescents: a cross-sectional study of autonomy and behavioral engagement

Abstract Objective Physical inactivity among adolescents is a worldwide public health concern. This study investigated the psychological motivation of adolescent exercise and the mechanisms by which diverse motives translate into actual behavioral engagement. We aimed to provide...