University of Southern California

Feasibility of Real‐Time Central Risk Assignment for Children's Oncology Group Pediatric Renal Tumor Trials

BACKGROUND: The Children's Oncology Group (COG) AREN03B2 Renal Tumor Biology and Classification Study undertook real-time central reviews to enable accurate risk stratification for enrollment on therapeutic trials. The present study assessed the feasibility of the central review...

Polarity-aware knowledge graph reveals diet–microbiome–health mechanisms with relevance to muscle, immune and metabolic aging

Diet profoundly influences gut microbial composition and metabolism, yet mechanistic pathways linking dietary exposures to human health remain fragmented across the literature. To systematically organize and integrate this evidence, we constructed an evidence-weighted Diet-Microb...

The Tissue Systems Pathology Test Guides Physician Recommendations for Patients With Non-Dysplastic Barrett’s Esophagus: A Case Series From a Gastrointestinal Surgery Center

Background: Management strategies that rely on clinicopathologic factors have limited ability in risk-stratifying patients with Barrett’s esophagus (BE). The tissue systems pathology test (TissueCypher, TSP-9) is clinically validated to risk stratify patients with BE for progress...

Form and function of actin impacts actin health and aging

Abstract The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and pharmacologic perturbations of actin...

E-cigarette use and nicotine dependence among hospitalized youth: influence of nicotine metabolism and CYP2A6 variability

Background Youth e-cigarette use is a public health concern, yet cessation approaches remain suboptimal. In adults, faster nicotine metabolism is linked with better cessation outcomes with varenicline compared to nicotine replacement therapy (NRT). This remains unexplored in yout...

A Commotion in the Mind: Direct and Indirect Associations of Moral Injury Symptom Severity and Stoicism with Suicide Risk in U.S. Military Veterans

Moral injury (MI) and stoicism have mixed independent associations with suicide risk among U.S. military veterans, yet little is known about how these constructs interact. We examined direct and indirect associations among MI symptom severity, stoicism, and suicide risk. Study pa...

Neanderthal’s heel: How the Neanderthal’s external calcaneal shape uniquely differs from that of modern humans

Neanderthals exhibit unique morphological adaptations in their calcaneus compared to Homo sapiens , shedding light on distinct evolutionary pressures and functional requirements shaping their respective foot anatomy. This study assesses which calcaneal traits represent plesiomorp...

P1.141. A Machine Learning Model for Assessment of Conduit Perfusion in Robotic Assisted Minimally Invasive Esophagectomy Using Indocyanine Green

Abstract Topic Esophageal Cancer: Other Background Anastomotic leak remains a major complication in esophagectomy. Indocyanine Green (ICG) can assist with the assessment of conduit perfusion but remains subjective and prone to bias. Our lab has worked to design a computer vision...

Echoes across the divide: incivility and the fragmentation of issue publics in immigration discourse

As immigration remains one of the most polarizing issues in U.S. politics, public discourse around it has become increasingly uncivil, especially on social media. This longitudinal study examines how incivility spreads and escalates across ideologically opposed issue publics on X...

Conformal network link prediction with false discovery rate control under unstructured missingness

We propose a new method for predicting multiple missing links in partially observed networks while controlling the false discovery rate (FDR), a largely unresolved challenge in network analysis. The main difficulty lies in handling complex dependencies and unknown missing pattern...

Analysis and experiments of the dissipative Twistcar: direction reversal and asymptotic approximations

Abstract Underactuated wheeled vehicles are commonly studied as nonholonomic systems with periodic actuation. Twistcar is a classical example inspired by a riding toy, which has been analyzed using a planar model of a dynamical system with nonholonomic constraints. Most of the pr...

Insights into the relationship between menopausal timing and risk of cardiovascular disease: a systematic review and meta-analysis of Mendelian randomization analyses

Cardiovascular disease (CVD) is the leading cause of death and imposes a substantial burden on women’s health. Early onset of menopause, as a unique trait of reproductive aging, has been associated with a higher risk of adverse cardiovascular events in traditional observational s...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

The impact of NaOH, CaO, and [Ca 2+ ] + [HCO 3 − ] additions on PIC and POC formation in Los Angeles Harbor Waters

Abstract. Negative CO2 emission technologies such as ocean alkalinity enhancement, in tandem with emissions reduction are necessary to keep the climate system below a critical tipping point. While the biogeochemical consequences of alkalinity enhancement remain poorly constrained...

High-Value Care in Pediatric Critical Care: Intravenous to Enteral Gastrointestinal Medications

Advancing pediatric critical care medicine includes identifying and reducing health care costs while maintaining—and even enhancing—the delivery of high-value care. Gastrointestinal (GI) prophylaxis (PPX) is commonly prescribed for children in the pediatric intensive care unit (P...

Temporally regulated FGFR2-retinoic acid signaling mediates dura mater-suture mesenchyme interactions to prevent craniosynostosis in mice

Congenital anomalies often arise during critical developmental time windows, yet the underlying mechanisms remain unclear. Here, we identify a time-specific FGFR2-retinoic acid signaling axis regulating postnatal coronal suture development through dura mater-suture mesenchyme int...

Semi-universality of CFT$_d$ entropy at large spin

The thermal partition function, Z <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mi>Z</mml:mi> </mml:math> , of a CFT_d <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow> <mml:mi>C</mml:mi> <mml:mi>F</mml:mi> <mm...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Circles of Confidence for Multi‐Label Geometry Completion

Abstract Inside–outside classification is widely used for geometry processing tasks such as surface reconstruction, geometry completion, and calculating signed distance fields. We introduce a new integral formulation of this problem, which assigns confidence scores that points ar...

Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex

Understanding how cellular architecture organizes cortical function requires mesoscopic approaches that resolve structure-function coupling in vivo. Here we introduce cerebral blood flow (CBF) and cell-body staining intensity (CSI) similarity index (CCSI), a localized similarity...