University of Southern California

Circulating 27-hydroxycholesterol, sex steroid hormones, and risk of mortality among postmenopausal females with breast cancer: The Multiethnic Cohort Study

Abstract Background: Biomarkers in the hormonal and metabolic pathways linking obesity and mortality can influence survival after breast cancer diagnosis. Methods: We prospectively examined associations with mortality for pre-diagnostic plasma levels of circulating 27-hydroxychol...

Big data and psychiatry: advances, constraints and future directions.

Early work in psychiatry research, often involving single sites, small samples, and limited variables, has shifted to contemporary research involving multiple sites, large samples, and many variables. Such research raises important questions, including concerns about data quality...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Mortality Research With Artificial Intelligence Tools: Applying Language Models to the National Violent Death Reporting System Suicide Narratives, 2003-2023.

. 2026;116(10):1550-1556. https://doi.org/10.2105/AJPH.2026.308618).

The global burden of metabolic and alcohol-associated liver disease (MetALD).

Chronic liver disease is a leading cause of global morbidity and mortality, with an evolving etiologic landscape driven by rising metabolic dysfunction and persistent alcohol use. The introduction of metabolic and alcohol-associated liver disease (MetALD) recognizes the coexisten...

Rapid urban land uplift enhanced by crustal faults during groundwater recovery

Abstract Urban land subsidence driven by groundwater extraction is widespread, but the processes governing how groundwater recovery translates into spatially variable surface uplift remain poorly understood. We use satellite geodesy and multi-decadal groundwater observations to m...

Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in a multiethnic US population

Abstract Neuroinflammation is associated with depression and anxiety risk, both of which demonstrate a bilateral relationship with cardiometabolic disorders. Systemic inflammation was also commonly described in patients with cardiometabolic disorders. It is, thus, unclear whether...

Achieving physiologic distensibility targets frequently requires modification of standard cruroplasty during anti-reflux surgery

Abstract Background Intraoperative EndoFLIP provides objective assessment of esophagogastric junction (EGJ) distensibility during anti-reflux surgery, and final distensibility index (DI) values of 2.0–3.5 mm 2 /mmHg have been associated with improved reflux control while minimizi...

Predictive Performance of Screening Methods for Neonatal Opioid Withdrawal Syndrome

BACKGROUND: Routine urine substance screening (USS) in pregnant women for perinatal substance exposure is associated with bias and has limited evidence supporting its use. We evaluated agreement between maternal disclosure, maternal and neonatal USS, and their predictive abilitie...

The downward legacy of a phytoplankton bloom in the oligotrophic North Pacific Subtropical Gyre

Abstract Ocean particles are a heterogeneous collection, including living and dead cells, feces, mucus‐rich aggregates, and mineral shells and frustules. In the well‐lit upper ocean, phototrophic processes fuel production of particulate matter; however, only a relatively small pe...

Neuroepithelial regulation across development, regeneration, aging, and sex

The skin is a highly innervated organ in which neural circuits continuously interact with epithelial, immune, and stromal compartments to coordinate tissue function. Historically, sensory and sympathetic nerves were viewed primarily as conduits for environmental input and autonom...

Amphiphilic Peptide Fusion Promotes Endocytic Uptake of Nanodiscs

A major limitation across nanoparticle delivery platforms is inefficient intracellular delivery following cellular uptake, often resulting from sequestration within endosomal compartments. Here, we show that peptide architecture can influence intracellular trafficking and reduce...

HSV-1 UL42 and UL47 hijack cellular nucleotide synthetic enzyme CAD to promote lytic replication

ABSTRACT Cellular metabolic enzymes are well defined for their roles in metabolism, and their function beyond metabolism is poorly defined. Here, we report that herpes simplex virus 1 (HSV-1) couples evasion of the inflammatory response to metabolic activation to promote lytic re...

Cost analysis of venous stent reconstruction in the treatment of chronic lower extremity venous occlusive disease

As healthcare costs approach 20% of the United States’ gross domestic product, accurate healthcare cost accounting has become increasingly important [ 1 ]. Increases in the direct cost of hospital-based care have been predominant drivers of overall healthcare spending [ 1 , 2 , 3...

Causal Language in Post Titles Shapes Deeper Topological Structures of Online Conversations

Causal reasoning is fundamental to human understanding and information organization. People prefer causal explanations because they offer coherence, predictability, and a sense of control. Conversational structures shape how knowledge and perspectives are shared, validated, and a...

Bridging Knowledge Gaps in Clinical AI: An Activity Theory Perspective on Interdisciplinary Data Work for Telehealth

Advanced AI technologies are increasingly integrated into clinical domains to advance patient care. The design and development of clinical AI technologies necessitate seamless collaboration between clinical and technical experts. However, such interdisciplinary teams are often un...

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower‐risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo‐controlled trial

BACKGROUND: Vitamin C (VitC) is a cofactor for TET enzymes involved in DNA demethylation and epigenetic regulation. Mutations in TET2 are common drivers of leukemia. Preclinical studies suggest that VitC may delay leukemia progression. This study aimed to evaluate the biological...

Non-stabilizerness and violations of CHSH inequalities

We study quantitatively the interplay between entanglement and non-stabilizer resources in violating the CHSH inequalities. We show that, while non-stabilizer resources are necessary, they must have a specific structure, namely they need to be both asymmetric and (surprisingly) l...

JuRa: The Juventas Radar on Hera Mission to Probe Internal Structure of Didymos and Dimorphos Asteroids

Abstract JuRa, the Juventas Radar, is the sounding radar of the Hera/ESA mission on cruise to the asteroid Didymos and its moon, Dimorphos. In 2027, it will, for the first time, do direct observation of the internal structure of an asteroid for the benefit of both science and pla...

Multiparadigm Benchmark of Molecular Docking: From Physics to Co-Folding and Hybrid Models

Abstract Generalizability of molecular docking predictions across novel protein targets and distinct small-molecule chemotypes is key to the successful application of deep learning co-folding approaches in drug discovery, as highlighted by recent benchmarks, including Runs-n-Pose...