University of Southern California

Postoperative Interventions and Cost Associated With Disposition After Tonsil and Adenoidectomy

OBJECTIVE To evaluate postoperative disposition and resource use among patients admitted to the inpatient unit or pediatric intensive care unit (PICU) following tonsillectomy, adenoidectomy, and tonsillectomy/adenoidectomy (T/A). PATIENTS AND METHODS This retrospective cohort stu...

Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation

Insulin resistance (IR) has emerged as a risk factor for lactation insufficiency and delays the onset of milk secretion after childbirth, termed secretory activation (SA). This may cause inadequate infant weight gain and early breastfeeding cessation. However, the mechanisms unde...

Forest canopy decline under elevated CO 2 during the Paleocene-Eocene Thermal Maximum

Uncertainty remains regarding the impact of rapid anthropogenic warming on forest ecosystem structure, biodiversity, and function. As an analog, we reconstruct forest canopy density and compositional change in Wyoming, USA, through the Paleocene-Eocene Thermal Maximum (PETM), an...

Demographic and Service-related Correlates of Moral Injury Symptoms in U.S. Military Populations

Introduction: Moral injury, the psychological distress from perceived transgressions of deeply held moral values, is distinct from moral distress and fear-based conditions such as PTSD. While combat exposure has received significant attention, less is known about how demographic...

“We cannot rely on foreign entities to take care of our health… we need to change our mindset”: immediate impacts of the 2025 U.S. government funding cuts on health in Kenya

In 2024, the United States Government (USG) distributed $730 million of development assistance for health to Kenya, much of which supported HIV care; in early 2025, almost all USG funding was abruptly halted. This study explores the impacts of the funding cuts on uptake of health...

Exohedral 1:2Complexes of Lanthanide Atoms with theC60 Fullerene: What Hapticity Is Preferred, η10, η11, or η12?

Abstract The structure of crystalline lanthanide–C60 fullerides allows for the Ln atom coordination to two rings of adjacent fullerene molecules simultaneously, where the resulting Ln hapticity can be η10, η11, or η12. We analyze the geometries, bonding strength, charge, spin, an...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

Cancer Screening and Citizenship Status in the US

Importance: Immigrants without US citizenship, or noncitizens, disproportionately endure poverty, labor exclusions, and inadequate health care access-structural drivers of adverse cancer outcomes. While screening is critical for preventing cancer deaths, and cancer is the leading...

Microstructure and microhardness of molybdenum processed by monotonic and cyclic high-pressure torsion

Abstract High-pressure torsion (HPT) was employed to investigate the effects of monotonic and cyclic shear deformation on the microstructural evolution and hardness of commercial purity molybdenum processed at room temperature (RT). Disks were subjected to monotonic HPT (m-HPT) a...

A spatially discretized convolutional neural mass model for studying meso-scale spatio-temporal transformations in the rat hippocampus

The brain operates across multiple spatial and temporal scales, necessitating computationally efficient models that link micro-scale mechanisms to meso- and macro-scale dynamics. Here, we introduce a novel convolutional neural mass model (CNMM) that computes the meso-scale activi...

Ultrafast Auger-MediatedInterlayer Electron Transferin 2D Perovskites: Ab Initio Quantum Dynamics Simulation

Abstract Interlayer charge transport in two-dimensional perovskites is limited by the electronically insulating nature of spacer cations. Here, we identify an unconventional, highly efficient mechanism that overcomes this limitation. Ab initio quantum dynamics reveals that spacer...

Protocol of a randomized controlled trial evaluating telehealth delivery of the Brief Alcohol Screening and Intervention for College Students (BASICS) program

This study is a randomized controlled trial evaluating a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS) program as an equally efficacious alternative to the traditional in-person implementation. The study will recruit 600 college...

Five Myths About Influence Operations: What 25 Million Tweets Across Seven State Campaigns Reveal

A set of “stylized facts” about state-backed influence operations now circulates across journalism, policy, and the peer-reviewed literature: that they are monolithic troll armies; that they win by weaponizing moral-emotional language; that they manufacture their own virality; th...

“Molecular divergence shapes lung- and liver-preferential metastasis in HER2-positive breast cancer”

Abstract Metastatic colonization of distant organs remains the primary cause of breast-cancer-specific mortality, yet the underlying mechanisms governing organ-preferential colonization remain poorly understood. To better delineate the underlying mechanisms to establish successfu...

Assessing spatial heterogeneity of active layer thickness over Arctic-foothills tundra, North Slope Alaska

Abstract. Changes in active layer thickness (ALT) are used as an indicator of permafrost degradation. Increases in ALT can lead to increased greenhouse gas emissions, altered hydrology and ecology, ground instability, and a positive climate feedback. Quantifying ALT spatial heter...

Pseudo-RGB Slice Stacking in 2D ResUNet for High-Sensitivity Multiple Sclerosis Lesion Segmentation

Background: Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, affecting more than 2.8 million individuals worldwide. Automated segmentation of white matter lesions on fluid-attenuated inversion recovery (FLAIR) magnetic resonance...

Shifts in Clinical Practice–Changing Acute Ischemic Stroke Research Over the Past Decade

BACKGROUND: The past decade has witnessed rapid growth of clinical trial programs in Europe and Asia, with randomized clinical trials (RCTs) publications from these regions outpacing those of the United States. However, limited data exist quantifying their relative influence on p...

Lifestyle Medicine Competencies in Women’s Health: Consensus-Based Standards From the International Board of Lifestyle Medicine

Lifestyle medicine (LM) takes an evidence-based approach to the prevention and management of many conditions affecting women; however, no dedicated competency framework currently guides its application across the life span. We aimed to develop a comprehensive set of core competen...

Deformation behavior of plastic-metal hybrid components for optical image stabilization: from injection molding to thermal processing

Abstract Micro-structured plastic-metal hybrid (MPMH) components fabricated by insert injection molding are widely used in miniaturized optical modules because of their structural integration and multifunctional performance. However, the multi-stage processes from injection moldi...

A comprehensive assessment of tandem repeat genotyping methods for Nanopore long-read genomes

Tandem repeats play critical roles in human disease and phenotypic diversity but are among the most challenging classes of genomic variation to measure accurately. Long-read sequencing has the potential to accurately characterize long and complex tandem repeats. While an increasi...