University of Southern California

Impact of post‐chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children’s Oncology Group AREN0532, AREN0533, and AREN03B2 studies

Abstract Background Improvements in therapy for patients with favorable histology Wilms tumor (FHWT) have relied on refinement of risk stratification for therapeutic assignment through identification of favorable and unfavorable prognostic factors. Although well established in In...

Age-Friendly Health Systems in Hospital at Home: An Integrated Healthcare System Cross-Sectional Survey

Background Age-Friendly Health Systems (AFHS) is an evidenced-based initiative structured on the 4Ms framework (What Matters, Medications, Mentation, and Mobility) to improve care for older adult patients and has been implemented across the United States in various care settings....

Nontraumatic Osteonecrosis of the Femoral Head: An Update.

➢ Nontraumatic osteonecrosis of the femoral head should be suspected in patients who are <50 years of age who have persistent hip pain despite normal radiographs. ➢ Bilateral involvement is common; magnetic resonance imaging (MRI) of the contralateral hip is recommended. ➢ MRI is...

Sex-specific biological aging clocks across organs and omics

Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer’s disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex in...

Virtual parenting intervention to promote positive parenting and prevent child anxiety and depression symptoms among filipino americanfamilies: protocol for a randomized controlled trial

Filipino youth in the U.S. experience higher rates of depression, suicidal ideation, anxiety, and substance use when compared to other Asian subgroups and non-Hispanic whites, yet are less likely to seek help or receive preventive care. Evidence-based parenting interventions have...

Peristaltic forces drive tumor cell invasion in colorectal cancer

Mechanical forces are known to influence the progression of cancer; however, the impact of naturally occurring physical forces remains less well understood. With the advent of organ-on-chip (OOC) technology, preclinical models can now incorporate human-relevant physiological forc...

Asymptotic FDR Control with Model-X Knockoffs: Is Moments Matching Sufficient?

We propose a unified theoretical framework for studying the robustness of the model-X knockoffs framework by investigating the asymptotic false discovery rate (FDR) control of the practically implemented approximate knockoffs procedure. This procedure deviates from the model-X kn...

Artificial Intelligence Across the PET Reconstruction Pipeline: An Update

PET reconstruction has evolved from analytic and iterative physics-based methods toward hybrid approaches that increasingly incorporate artificial intelligence (AI). As digital detectors, long-axial FOV systems, and time-of-flight technology increase data richness and computation...

Endoscopic spine surgery: a bibliometric and citation analysis of the most influential articles and authors across 19 spine journals (1976–2025)

Abstract Purpose To understand the development and trajectory of endoscopic spine surgery. Methods The Web of Science Core Collection was searched for full-endoscopic and microendoscopic spine surgery articles published in 19 spine-related journals. Citation analysis identified t...

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort

Background: Increasing exposure to wildfire fine particulate matter (PM 2.5 ) may pose unique risks to fetal development. We assessed associations between prenatal wildfire PM 2.5 exposure and fetal growth outcomes, including birth weight at term, birth weight for gestational age...

New implementation of mixed-reference spin-flip time-dependent density functional theory and application to molecules with variable diradical character and conical intersections

Mixed-reference spin-flip time-dependent density functional theory (MRSF-TDDFT) improves upon the original spin-flip TDDFT (SF-TDDFT) approach by expanding the configurational space of the response states via a mixed-reference reduced density matrix, specifically, an equal mixtur...

Sexual Harassment and Abuse in Young Adulthood and Mental Health Outcomes

This cohort study analyzes mental health trajectories before and after experiences of sexual harassment and abuse among young adults.

The Scope Creep Myth: How Hierarchical Visibility Drives Escalation Rather Than Departure in Multi-Agent Systems

When an orchestrator delegates a subtask to a worker agent, it must decide how much context from the supervising hierarchy to expose. Current engineering practice diverges sharply: systems either isolate workers to their immediate assignment or forward the full execution transcri...

The Scope Creep Myth: How Hierarchical Visibility Drives Escalation Rather Than Departure in Multi-Agent Systems

When an orchestrator delegates a subtask to a worker agent, it must decide how much context from the supervising hierarchy to expose. Current engineering practice diverges sharply: systems either isolate workers to their immediate assignment or forward the full execution transcri...

A stakeholder-engaged process to design and implement the Assessment of Cognitive Complaints Toolkit for Alzheimer’s Disease (ACCT-AD) in primary care

Background: Dementia is underdiagnosed, particularly in primary care settings where most people receive their healthcare. These is a need for tools to assist with the diagnosis of dementia by primary care clinicians, who greatly outnumber specialists. Objective: To describe the c...

Large-scale benchmarking of prokaryotic annotation tools across thousands of species

Abstract Background Genome annotation is an important step in deriving functional meaning from prokaryotic sequencing data, yet systematic evaluations guiding tool selection are lacking. We present the first large-scale investigation of four prominent open-source annotation tools...

Criminal Trial Attorney Questions About Parent Conflict when Children Testify Against a Parent in Child Sexual Abuse Cases

When a parent is accused of child sexual abuse (CSA), parent conflict raises concerns about allegation credibility. However, little is known about how attorneys question children about parent conflict. We examined 21,863 question-answer pairs from 53 testimonies of 6- to 17-year-...

Meta-regression model choice and the interpretation of trial-level surrogacy

The use of surrogate endpoints can improve feasibility of clinical trials. The results of trial-level analyses are a key factor affecting regulatory policy regarding the uptake of a surrogate endpoint. Trial-level analyses aim to quantify the strength of association between treat...

Psychological Need Satisfaction During Physical Activity: Differences Across Physical and Social Contexts in a Large-Scale Study

Physical inactivity is a public health problem. Accordingly, there is growing interest in whether engaging in physical activity (PA) that satisfies psychological needs (e.g. safety, novelty) is more likely to be sustained. Physical and social PA contexts (e.g. where, with whom, l...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...