University of Southern California

JuRa: The Juventas Radar on Hera Mission to Probe Internal Structure of Didymos and Dimorphos Asteroids

Abstract JuRa, the Juventas Radar, is the sounding radar of the Hera/ESA mission on cruise to the asteroid Didymos and its moon, Dimorphos. In 2027, it will, for the first time, do direct observation of the internal structure of an asteroid for the benefit of both science and pla...

Longitudinal electric vehicle adoption patterns and neighborhood predictors in California

Objective Prior studies of determinants of Zero-Emission Vehicle (ZEV) adoption have relied largely on cross-sectional data, obscuring temporal variation. We identified ZEV adoption trajectories in California ZIP Code Tabulation Areas (ZCTAs) and related them to neighborhood dete...

A phase 4, open-label efficacy and safety study of methotrexate and monthly pegloticase co-administration in patients with uncontrolled gout

Abstract Background Pegloticase is an infused pegylated uricase enzyme indicated for the treatment of uncontrolled gout in adults who did not respond to or cannot tolerate oral urate-lowering therapies; pegloticase is administered as 8-mg infusions every 2 weeks (Q2W). However, f...

Tangier Disease

Abstract Purpose of Review We describe two patients with Tangier disease (TD) and provide a narrative review of its clinical features, genetics, diagnosis, and management. A literature search of PubMed and Google Scholar was performed to identify English-language publications on...

Use of cannabidiol products in Canada, United States, Australia, Aotearoa New Zealand, United Kingdom and Germany: products, sources and reasons for use

Background Cannabidiol (CBD) has attracted scientific, clinical, and public interest due to its perceived therapeutic benefits and favourable safety profile. However, a gap remains in understanding how different CBD-only regulatory frameworks shape consumers interaction with the...

Do rights offerings reduce bargaining complexity in Chapter 11?

This paper investigates the role of rights offerings in U.S. Chapter 11 reorganizations as a new market-based mechanism for mitigating bargaining frictions. Using novel hand-collected data, I document three facts: (i) over the past two decades, rights offerings financed 35% of la...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

A standardized field framework for integrated microbiological and geochemical sampling of deeply-sourced seeps across large-scale geological gradients

Accessing the deep subsurface biosphere remains a major challenge in Earth and planetary sciences. Drilling provides direct access but is costly, spatially restricted, and difficult to deploy at the scales required to investigate interactions between geological processes and micr...

Adolescents’ Experiences of Online Harms by Platform

Importance Concerns about the risks adolescents face online are rising, and existing research on online harms rarely examines platform-level differences. Objective To estimate the prevalence of negative experiences reported by US adolescents online, offline, and across 20 differe...

From influence to empowerment: Unpacking capacity building and social learning in virtual communities

This study explores how independent travel empowers women travel influencers and how meanings of empowerment are negotiated through interactions with their followers by examining the empowerment process at both individual and social levels. Drawing on capacity building theory and...

Predictable and Scalable Analog Matrix–Vector Multiplication in Memristor Crossbars via Closed‐Form Wire‐Resistance Compensation

ABSTRACT Wire resistance in memristor crossbars introduces geometry‐dependent voltage attenuation that degrades analog matrix–vector multiplication (MVM), while parasitic sneak paths further distort output currents as array dimensions scale. Here, we develop a closed‐form distrib...

Prospective associations between living in a smart growth community and children’s obesity risk measured by BMI percentile and waist circumference‑to‑height ratio

Obesity continues to be among the leading health concerns in the U.S. Smart Growth (SG) community development principles encourage physical activity and social engagement, which hold the potential to mitigate obesity risks in youth. This study examined the prospective association...

Phase-field analysis of fracture in casing–cement–rock wellbore systems: Effects of casing eccentricity and cement–rock interface strength

Predicting the initiation and propagation of cracks in heterogeneous wellbore systems under complex in-situ conditions remains challenging. We present a hybrid phase-field fracture framework to model crack growth in heterogeneous wellbore systems with weak interfaces. The framewo...

Console-Associated Surgical Workflow Performance in Vitreoretinal Surgery: A Comparative Time-and-Motion Study of UNITY VCS and CONSTELLATION Vision Systems

Vitreoretinal operating rooms face increasing challenges, including workforce shortages and growing patient demand from aging populations. This comparative time-and-motion study assessed if the UNITY® Vitreoretinal Cataract System (UNITY VCS) was associated with differences in co...

Client-Level Effects of States’ Mental Health Agency Expenditures and Mental Health Parity Legislation

OBJECTIVE: Despite federal parity legislation, gaps in access to behavioral health care persist across the United States. Stronger parity implementation has been associated with an improved system-level mental health infrastructure. The authors determined whether parity and highe...

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

In vitro studies of cancer cell behavior are often limited in translational capability due to the absence of in vivo characteristics, such as the tumor microenvironment (TME), that largely govern this behavior. The TME includes a dense, highly organized network of proteins that f...

“Provided power is there, it will be a good initiative”: healthcare provider perspectives on diagnostic screening for curable STIs during pregnancy in Botswana

Diagnostic screening for curable sexually transmitted infections (STIs) during antenatal care has the potential to improve health outcomes among women and infants in low- and middle-income countries (LMICs). To inform roll-out and scale up of antenatal STI screening in LMICs, it...

Pharmacokinetics and Physiologically Based Pharmacokinetic Modeling of Mycobacteriophages: Insights into Pulmonary Distribution and Clearance

Abstract Bacteriophage therapy is being explored as an alternate therapeutic approach for treating drug-resistant bacteria, including mycobacteria. However, rational phage dosing remains limited by scarce pharmacokinetic (PK) data and an incomplete understanding of tissue distrib...

Impact of post‐chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children’s Oncology Group AREN0532, AREN0533, and AREN03B2 studies

Abstract Background Improvements in therapy for patients with favorable histology Wilms tumor (FHWT) have relied on refinement of risk stratification for therapeutic assignment through identification of favorable and unfavorable prognostic factors. Although well established in In...

DELAYED ADMINISTRATION OF DIRECT ORAL ANTICOAGULANTS REDUCES TRANSFUSION RISK WHILE NOT INCREASING VENOUS THROMBOEMBOLISM RISK FOLLOWING REVISION TOTAL KNEE ARTHROPLASTY

Introduction Direct oral anticoagulants (DOACs) such as apixaban and rivaroxaban are effective prophylactic agents for preventing venous thromboembolism (VTE) following revision total knee arthroplasty (rTKA). However, the optimal timing for postoperative initiation of these agen...