University of Southern California

Protocol of a randomized controlled trial evaluating telehealth delivery of the Brief Alcohol Screening and Intervention for College Students (BASICS) program

This study is a randomized controlled trial evaluating a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS) program as an equally efficacious alternative to the traditional in-person implementation. The study will recruit 600 college...

A spatially discretized convolutional neural mass model for studying meso-scale spatio-temporal transformations in the rat hippocampus

The brain operates across multiple spatial and temporal scales, necessitating computationally efficient models that link micro-scale mechanisms to meso- and macro-scale dynamics. Here, we introduce a novel convolutional neural mass model (CNMM) that computes the meso-scale activi...

Cancer Screening and Citizenship Status in the US

Importance: Immigrants without US citizenship, or noncitizens, disproportionately endure poverty, labor exclusions, and inadequate health care access-structural drivers of adverse cancer outcomes. While screening is critical for preventing cancer deaths, and cancer is the leading...

Ultrafast Auger-MediatedInterlayer Electron Transferin 2D Perovskites: Ab Initio Quantum Dynamics Simulation

Abstract Interlayer charge transport in two-dimensional perovskites is limited by the electronically insulating nature of spacer cations. Here, we identify an unconventional, highly efficient mechanism that overcomes this limitation. Ab initio quantum dynamics reveals that spacer...

Microstructure and microhardness of molybdenum processed by monotonic and cyclic high-pressure torsion

Abstract High-pressure torsion (HPT) was employed to investigate the effects of monotonic and cyclic shear deformation on the microstructural evolution and hardness of commercial purity molybdenum processed at room temperature (RT). Disks were subjected to monotonic HPT (m-HPT) a...

Five Myths About Influence Operations: What 25 Million Tweets Across Seven State Campaigns Reveal

A set of “stylized facts” about state-backed influence operations now circulates across journalism, policy, and the peer-reviewed literature: that they are monolithic troll armies; that they win by weaponizing moral-emotional language; that they manufacture their own virality; th...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

“Molecular divergence shapes lung- and liver-preferential metastasis in HER2-positive breast cancer”

Abstract Metastatic colonization of distant organs remains the primary cause of breast-cancer-specific mortality, yet the underlying mechanisms governing organ-preferential colonization remain poorly understood. To better delineate the underlying mechanisms to establish successfu...

Assessing spatial heterogeneity of active layer thickness over Arctic-foothills tundra, North Slope Alaska

Abstract. Changes in active layer thickness (ALT) are used as an indicator of permafrost degradation. Increases in ALT can lead to increased greenhouse gas emissions, altered hydrology and ecology, ground instability, and a positive climate feedback. Quantifying ALT spatial heter...

Pseudo-RGB Slice Stacking in 2D ResUNet for High-Sensitivity Multiple Sclerosis Lesion Segmentation

Background: Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, affecting more than 2.8 million individuals worldwide. Automated segmentation of white matter lesions on fluid-attenuated inversion recovery (FLAIR) magnetic resonance...

Shifts in Clinical Practice–Changing Acute Ischemic Stroke Research Over the Past Decade

BACKGROUND: The past decade has witnessed rapid growth of clinical trial programs in Europe and Asia, with randomized clinical trials (RCTs) publications from these regions outpacing those of the United States. However, limited data exist quantifying their relative influence on p...

Deformation behavior of plastic-metal hybrid components for optical image stabilization: from injection molding to thermal processing

Abstract Micro-structured plastic-metal hybrid (MPMH) components fabricated by insert injection molding are widely used in miniaturized optical modules because of their structural integration and multifunctional performance. However, the multi-stage processes from injection moldi...

Lifestyle Medicine Competencies in Women’s Health: Consensus-Based Standards From the International Board of Lifestyle Medicine

Lifestyle medicine (LM) takes an evidence-based approach to the prevention and management of many conditions affecting women; however, no dedicated competency framework currently guides its application across the life span. We aimed to develop a comprehensive set of core competen...

A comprehensive assessment of tandem repeat genotyping methods for Nanopore long-read genomes

Tandem repeats play critical roles in human disease and phenotypic diversity but are among the most challenging classes of genomic variation to measure accurately. Long-read sequencing has the potential to accurately characterize long and complex tandem repeats. While an increasi...

Infrared spectroscopy of H3+ and Hn+ ions in helium nanodroplets

This work reports the infrared laser spectroscopic study of the H3+ and Hn+ (n = 5, 6, 7, 9) ions in helium droplets. The ions were produced upon electron impact ionization of helium droplets and charge transfer to small hydrogen clusters formed within the He droplets. The spectr...

Electrochemical Evaluation of Polymer-Based Microelectrode Arrays: Analytical Performance on Oxygen and Hydrogen Peroxide

This study investigates the electrochemical properties of polymer-based microelectrode arrays (pMEAs) and their performance in measuring oxygen (O2) and hydrogen peroxide (H2O2). Morphological characterization by scanning electron microscopy (SEM), energy-dispersive X-ray spectro...

Modeling collision-induced fragmentation in commonly-used ionic liquid propellants for electrospray thrusters

The performance of electrospray thrusters is constrained by molecular fragmentation that broadens charge-to-mass distributions and reduces thrust per unit power. To extend understanding beyond the most studied ionic liquid ion source propellants, a comparative collision study was...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...

JNK and p53 cause human and mouse β cell death during excessive unfolded protein response

Endoplasmic reticulum (ER) stress contributes to β cell death in both Type 1 and Type 2 diabetes (T1D and T2D). However, the molecular mechanisms driving β cell death during ER stress remain insufficiently defined, limiting development of protective therapies. GRP78, an ER chaper...

“You have to sell them as much as they’re trying to sell you”: U.S. Local Television News Directors’ Perspectives on the Struggle to Hire Reporters and Producers

This qualitative study examines hiring difficulties in local television (TV) news in small and medium TV markets (DMA #30+). The results of in-depth interviews showed that most interviewed news directors experienced talent shortages in their markets and had fewer and less prepare...