University of Southern California

Prevalence and Characteristics of Mental Health Interventions Following Pediatric Hospitalization

BACKGROUND AND OBJECTIVES: As survival after pediatric critical illness improves, attention has shifted to post-intensive care syndrome and the long-term mental health of pediatric intensive care unit (PICU) survivors, who have high rates of posttraumatic stress, anxiety, and dep...

Orthogonal dualities of dynamic stochastic higher spin vertex models, using the Drinfeld twister

Abstract We introduce a new algebraic method to construct duality functions for integrable dynamic models. This method will be implemented on dynamic stochastic higher spin vertex models, where we prove that the resulting duality functions between the dynamic stochastic higher sp...

Initial Z-Drug Prescription Duration and Long-Term Use

This cohort study evaluates the association between the days’ supply of an initial Z-drug prescription and subsequent long-term use.

A Causal Examination of the Solar Influence on Holocene Climate

Abstract Variations in Total Solar Irradiance (TSI) have long been hypothesized to influence global mean surface temperature (GMST) on multidecadal to millennial timescales, but empirical evidence has remained elusive. Here, we explore the link between solar variability and clima...

Socializing in the Digital Era: Examining How Social Activities Influence Momentary Emotions in Mothers of Infants

Abstract The transition to parenthood is a period of heightened emotion; while deeply rewarding, it is also a stressful time, marked by an increased risk of mental health problems. Socializing is vital for parents’ mental health and may buffer these risks. However, little is know...

Evaluating pharmacological targeting of actin regulatory pathways during aging in C. elegans

Abstract Actin is a highly conserved cytoskeletal protein that regulates numerous cellular processes essential for tissue homeostasis and healthy aging. Although genetic studies have established important roles for actin and actin-binding proteins in longevity, pharmacological ap...

Safety and Performance of the Colovac Anastomosis Protection Device. A Pooled Analysis of Prospective Studies Compared With Diverting Loop Ileostomy (SAFE-2025)

Objective: To compare the safety and effectiveness of the Colovac Anastomosis Protection Device with standard diverting ostomy (DO) following low anterior resection (LAR) for rectal cancer. Summary Background Data: DO is standard of care (SOC) following LAR for rectal cancer but...

Pushing the boundaries of virtual screening scale of combinatorial spaces with the V-SYNTHES approach

Computational screening of giga-scale chemical spaces opens a cost-effective path to high-quality hit identification, providing entry points for drug discovery. As these on-demand spaces grow and successful applications multiply, rigorous blind benchmarks like CACHE Challenges pr...

Model Falsification for Predicting Dynamical Responses of Uncertain Structural Systems

Abstract Accurate prediction of the dynamical response of a structural system depends on appropriate modeling of that system. However, modeling becomes increasingly challenging when numerous candidate models are available to describe the system behavior. Although different model...

Delayed submarine caldera subsidence creates extreme tsunami hazard

The 2022 Hunga volcano eruption generated one of the largest and most destructive volcanic tsunamis ever recorded. We interpret the timing, nature and relative hazard of volcanic-tsunamigenic processes by combining geophysical, oceanographic, atmospheric, and eye-witness observat...

Hunting for microsatellite instability in long-read data with Owl

Abstract Microsatellite instability (MSI) is a key biomarker of mismatch repair deficiency and response to immunotherapy, yet most existing genomic detection methods are optimized for short-read sequencing and rely on small panels of homopolymer markers, limiting the ability to c...

Associations of momentary food availability and appetitive drive with adolescents' food intake and dysregulated eating in a community sample of adolescents: The moderating role of trait hedonic hunger

Abstract Using ecological momentary assessment (EMA), we tested whether momentary palatable food availability and appetitive drive predict adolescents' palatable food/drink intake and dysregulated eating and whether trait hedonic hunger moderates these momentary links. Adolescent...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

How to train your resistive network: Generalized equilibrium propagation and analytical learning

Machine learning is a powerful method of extracting meaning from data; unfortunately, current digital hardware is extremely energy-intensive. There is interest in an alternative analog computing implementation that could match the performance of traditional machine learning while...

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

ABSTRACT Synaptic dysfunction is a major driver of cognitive decline in Alzheimer's disease (AD), yet its extent and molecular basis in the retina remain poorly defined. We integrated postmortem retinal and matched brain histopathology with ultrastructural, proteomic, biochemical...

Impact of Fidaxomicin De-Restriction on Clostridioides difficile Episodes in Hospitalized Pediatric Cellular Therapy Patients

Abstract Background Pediatric patients undergoing cellular therapy (CT) with hematopoietic cell transplantation (HCT) or chimeric antigen receptor T-cell (CAR-T) therapy are vulnerable to Clostridioides difficile infection (CDI). Recent guidelines recommend fidaxomicin treatment...

From Locked Out to Opting in: How the Cures Act Reshaped Medicare Advantage Utilization for Beneficiaries With End‐Stage Kidney Disease

OBJECTIVE: To describe how the characteristics of Medicare Advantage (MA) beneficiaries with end-stage kidney disease (ESKD) changed after the 21st Century Cures Act expanded MA eligibility, and to document accompanying changes in utilization. STUDY SETTING AND DESIGN: The 2021 C...

Extended Follow-Up of Botensilimab Plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer Without Active Liver Metastases

PURPOSE: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti-CTLA-...

HIV and STI Co-infection and Migration-Related Social Vulnerability among Venezuelan Gay and Bisexual Migrants in Lima, Peru

BACKGROUND: This study examined HIV, bacterial STI co-infection, and migration-related vulnerability among Venezuelan gay, bisexual, and other men who have sex with men (GBM) in Lima, Peru. METHODS: A total of 306 Venezuelan GBM of any serostatus living in Lima, Peru, were recrui...

Disintermediation Governance and Complementor Innovation: An Empirical Look at Amazon.com

This study investigates how the platform’s disintermediation governance policy (i.e., the policy that disciplines complementors and consumers circumventing the platform to transact directly) affects complementors’ product innovation and launching strategies. We leverage a change...