University of Southern California

Electrochemical Evaluation of Polymer-Based Microelectrode Arrays: Analytical Performance on Oxygen and Hydrogen Peroxide

This study investigates the electrochemical properties of polymer-based microelectrode arrays (pMEAs) and their performance in measuring oxygen (O2) and hydrogen peroxide (H2O2). Morphological characterization by scanning electron microscopy (SEM), energy-dispersive X-ray spectro...

Infrared spectroscopy of H3+ and Hn+ ions in helium nanodroplets

This work reports the infrared laser spectroscopic study of the H3+ and Hn+ (n = 5, 6, 7, 9) ions in helium droplets. The ions were produced upon electron impact ionization of helium droplets and charge transfer to small hydrogen clusters formed within the He droplets. The spectr...

Surgical Management of Young Women with High-Risk Breast Cancer Receiving Neoadjuvant Systemic Therapy on the I-SPY2 Trial

BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...

Modeling collision-induced fragmentation in commonly-used ionic liquid propellants for electrospray thrusters

The performance of electrospray thrusters is constrained by molecular fragmentation that broadens charge-to-mass distributions and reduces thrust per unit power. To extend understanding beyond the most studied ionic liquid ion source propellants, a comparative collision study was...

JNK and p53 cause human and mouse β cell death during excessive unfolded protein response

Endoplasmic reticulum (ER) stress contributes to β cell death in both Type 1 and Type 2 diabetes (T1D and T2D). However, the molecular mechanisms driving β cell death during ER stress remain insufficiently defined, limiting development of protective therapies. GRP78, an ER chaper...

“You have to sell them as much as they’re trying to sell you”: U.S. Local Television News Directors’ Perspectives on the Struggle to Hire Reporters and Producers

This qualitative study examines hiring difficulties in local television (TV) news in small and medium TV markets (DMA #30+). The results of in-depth interviews showed that most interviewed news directors experienced talent shortages in their markets and had fewer and less prepare...

Burden of Dementia in Europe, 1990–2023: a systematic analysis from the Global Burden of Disease Study 2023

Background Dementia is a leading cause of disability and mortality in Europe, yet no recent harmonised assessment has described its impact across the European Union (EU-27) and the WHO European Region. Methods We used data from the Global Burden of Disease Study 2023 (GBD 2023) t...

FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging

Aging is a risk factor for the development and progression of metabolic impairments. Dietary protein restriction (DPR) is protective against obesity- and age-related metabolic decline by the induction of the fibroblast growth factor (FGF21), which regulates body weight, lipid han...

Win Probabilities in the First Ahead by at Least k Multinomial Game

Abstract Multinomial trials having probabilities $$p_1, \ldots , p_n$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mi>p</mml:mi> <mml:mn>1</mml:mn> </mml:msub> <mml:mo>,</mml:mo> <mml:mo>…</mml:mo> <mml:mo>,</mml:mo> <mml:msub> <mml:mi>p</...