University of Milan

Is there a new ‘right to Milan’? Neo-normative control and spacing practices in post-pandemic corporate spaces

In this study, we examine the spacing practices through which neo-normative control is both preserved and contested via organizational spatial renovations, focusing on the post-pandemic context of Milanese corporations. Between 2022 and early 2024, we collected field-level data f...

Vitamin D in coronary heart disease: a Mendelian randomization meta-analysis of data stratified by 25(OH)D levels

Maria Fusaro, Pasquale Perrone Filardi, Gianfranco Sinagra, Maria Luisa Brandi, Maurizio Gallieni, Jean-Yves Reginster, Eugene McCloskey, Etienne Cavalier,

What internal characteristics could explain US wineries targeting upper-tier price segments?

Purpose This paper aims to examine how internal strategic and organizational characteristics are associated with upper-tier list-price positioning among US wineries, moving beyond accounts that focus mainly on terroir or regional reputation. Four directional hypotheses, derived f...

Synergistic activity of colistin and stilbenoids against Pseudomonas aeruginosa clinical isolates

ABSTRACT Pseudomonas aeruginosa is a major opportunistic pathogen responsible for chronic lung infections in cystic fibrosis (CF) patients, contributing significantly to morbidity and mortality. In this study, we investigated the synergistic activity of colistin combined with two...

CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT—a systematic review

Abstract Objective Cardiac extracellular volume (ECV) is a quantitative imaging biomarker of myocardial interstitial expansion and diffuse fibrosis, with cardiac magnetic resonance regarded as the reference standard method for assessment. Interest in computed tomography (CT)-deri...

Balancing Risk and Reward: Red Fox Exploitation of Kill Sites in a Wolf‐Occupied Landscape

ABSTRACT In carnivore guilds, apex predators and mesocarnivores may interact through mechanisms ranging from antagonism to facilitation. The recent recolonization of the gray wolf Canis lupus in the Alps offers a valuable opportunity to investigate how wolf kill sites influence m...

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Purpose: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantification. Methods: This was a cross-sectional study. OCT scans of...

Comparative cost analysis of community-based tuberculosis screening: Computer-Aided Detection (CAD) alone versus CAD with point-of-care C-reactive protein testing in South Africa and Lesotho

Community-based active case finding (ACF) for tuberculosis (TB) is recommended in high-burden settings, yet evidence on implementation costs from prospective programmatic data remains limited. We estimated and compared the costs of two community-based ACF screening approaches: Co...

Development of an investigational epigenetic silencer therapy to transcriptionally inactivate viral DNA in chronic hepatitis B

Approved chronic hepatitis B therapies rarely result in functional cure, as they fail to permanently silence all transcriptionally active hepatitis B virus (HBV) DNA. CRMA-1001 employs an optimized epigenetic silencer that represses viral transcription through targeted deposition...

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

Smoking behaviours and attitudes among dental students in three European countries: a multicentre cross-sectional study

Tobacco use remains a major public health concern and a significant risk factor for systemic and oral diseases. Dental students, as future healthcare professionals, are expected to play an important role in tobacco control and smoking cessation. This multicentre study aimed to as...

Exploring the potential of cluster analysis in identifying disease phenotypes in CPPD: Moving from intuition to insight

BACKGROUND: Calcium pyrophosphate deposition (CPPD) disease is a heterogeneous condition and is frequently misdiagnosed due to the different clinical presentations and variable disease progression. Aim of this study is to identify clinical phenotypes of CPPD disease by integratin...

Outcomes and adverse events of postoperative stereotactic interventional radiotherapy/brachytherapy for brain metastases: a systematic review

Postoperative radiotherapy is commonly used after resection of brain metastases, but durable local control with a low rate of adverse events (AEs) remains challenging. This systematic review summarizes outcomes and AEs of postoperative stereotactic interventional radiotherapy (S-...

The Italian Nanomedicine Platform (INP): national integration within the European nanomedicine ecosystem

Italy’s nanomedicine expertise has long developed in fragmented manner, with limited coordination across academia, clinical institutions, industry and regulatory bodies. The Italian Nanomedicine Platform (INP) was established to integrate discovery, preclinical validation, regula...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...

A structural cardiac pathway mediates the risk of ischemic heart disease from TyG-related indices: A prospective cohort study

The triglyceride-glucose (TyG) index and its derivatives are surrogate markers of insulin resistance and are closely associated with cardiovascular risk. However, whether and to what extent they are associated with IHD risk through subclinical cardiac remodeling remains unclear....

The Role of Transparency in Repeated First-Price Auctions with Unknown Valuations

Abstract. We study the problem of regret minimization for a single bidder in a sequence of first-price auctions where the bidder discovers the item’s value only if the auction is won. Our main contribution is a complete characterization, up to logarithmic factors, of the minimax...

A comprehensive assessment of dairy farming sustainability based on stakeholder priorities and concerns: a case study in Northern Italy

Improving the sustainability of dairy farming requires the identification of practices and indicators that are both scientifically robust and applicable under different farming conditions. This study aimed at identifying priority practices, perceived barriers and monitoring indic...

Clinical evaluation of AI-assisted quantitative marrow fibrosis assessment using Continuous Indexing of Fibrosis (CIF)

Abstract Assessment of fibrosis is central to the evaluation of diagnostic bone marrow trephine (BMT) biopsies. However, manual fibrosis grading is subjective and only semi-quantitative. We evaluated the clinical utility of a previously developed AI-based quantitative fibrosis as...