University of Milan

Mapping therapeutic exercise interventions in temporomandibular disorders: A scoping review

OBJECTIVE: Temporomandibular disorders (TMDs) are musculoskeletal conditions causing pain and functional limitations. This scoping review aimed to map therapeutic exercise interventions described in clinical studies on TMDs. METHODS: Following Joanna Briggs Institute methodology,...

Bioactive Nanocoatings Encode Bacterial Settlement Cues for Coral Restoration

Abstract Increasing larval settlement can substantially accelerate coral reef restoration by overcoming a key bottleneck in coral population recovery. Successful settlement depends on biological and chemical cues associated with microbial biofilms and crustose coralline algae tha...

Refined Shrimp Peptide Concentrate: Regulatory, Value Chain and Circular Blue Bioeconomy Perspectives

The European Union Regulation (EU) 2015/2283 on novel foods has created new opportunities for the valorization of marine by-products within the framework of the circular bioeconomy and sustainable blue economy. Refined shrimp peptide concentrate (RSPC), obtained through enzymatic...

Steady Vortex Sheets in Presence of Surface Tension

Abstract In this paper, we construct a new class of uniformly rotating vortex sheets arising as perturbations of the circular configuration within the Kelvin–Helmholtz model for two incompressible fluids of equal density, with surface tension effects taken into account. Despite t...

Market size and strategic interaction in pharmaceutical price regulation

Abstract We present a model of optimal regulation in the presence of spillover effects and asymmetric countries, and we use it to study strategic interaction among countries in pharmaceutical price regulation, where the spillovers result from innovation in drug development. Regul...

The diminishing polyads of parenting: exploring cultural perspectives of ‘good parenting' using grounded theory analysis

Introduction This study investigates Italian parents' perceptions of ‘good parenting' and cultural variations. 250 mothers and 87 fathers were surveyed during the third trimester, with follow-ups at 6–12 weeks and 6 months postpartum. Methods Using Grounded Theory Analysis, data...

Integrating molecular subtypes, genomics and functional dependencies to identify context-specific therapeutic vulnerabilities in small cell lung cancer

Abstract Small cell lung cancer is one of the most aggressive malignancies, characterized by rapid tumor growth, early metastatic spread and extremely poor survival. Although most patients initially respond to platinum-based chemotherapy, relapse is almost inevitable and treatmen...

Laminar pattern disruption in fetal incipient polymicrogyria: insights from post-mortem magnetic resonance imaging and neuropathological correlation

Abstract Background Polymicrogyria is a heterogeneous cortical malformation resulting from disruption of multiple processes of cortical development, either genetically determined or acquired. Objective To characterize early imaging and histopathological features of incipient poly...

Het-node2vec: second-order random walk sampling for heterogeneous graph embedding

Abstract Many real-world problems are naturally modeled as heterogeneous graphs, where nodes and edges represent multiple types of entities and relations. Existing learning models for heterogeneous graph representation usually depend on the computation of specific, user-defined h...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Microglia-derived extracellular vesicles uncover early alterations of inflammatory signaling in Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is increasingly recognized as a neurodegenerative disorder associated with chronic low-grade inflammation and age-related immune dysregulation. Microglial-derived extracellular vesicles (MDEVs) are emerging as important mediators of neuroimmune c...

Temporal Dynamics of Clinical Response Following Fecal Microbiota Transplantation in Dogs with Chronic Enteropathy

Fecal microbiota transplantation (FMT) is a promising adjunctive treatment for dogs with chronic enteropathy (CE), but response is usually assessed at scheduled follow-up visits, potentially overlooking day-to-day fluctuations. This prospective observational study evaluated tempo...

KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution

Abstract The tumor suppressor KDM6A / UTX , a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosphorylation in several solid tumors, generating a pseudo-hyperoxic en...

Why do girls receive better grades in school? The role of students’ competencies, personality traits, school-related attitudes, and behaviour

This study investigates the gender gap in teacher-assigned grades in German and mathematics among 7th-grade students in Germany. Using rich data from the National Educational Panel Study (NEPS, N = 1,972 cases), we examine the extent to which observed differences in grades betwee...

Association of plasma growth differentiation factor-15 with the frailty phenotype – Evidence from the COGFRAIL study

Background Growth differentiation factor-15 (GDF-15) has been consistently associated with physical frailty. However, it remains unclear whether GDF-15 further discriminates adverse outcomes among older adults who are already physically and cognitively impaired. Objectives To eva...

Mapping the nuclear environments of extreme coronal line emitting galaxies

Abstract Extreme coronal line emitters (ECLEs) are a rare class of galactic nuclei exhibiting unusually strong high-ionisation forbidden emission lines, and several ECLEs have been linked to tidal disruption events (TDEs). In this work, we compile and analyse optical spectra of 3...

Chaperone-assisted selective autophagy (CASA) in polyglutamine-related diseases: From mechanisms to therapeutic perspectives

Chaperone-assisted selective autophagy (CASA) is a crucial process aimed at maintaining proteostasis in several neurodegenerative diseases associated with protein misfolding, including polyglutamine (polyQ) diseases. Autophagy is a critical lysosome-mediated degradation pathway,...

Genetic determinants of low von Willebrand factor from whole exome sequencing

Low von Willebrand factor (VWF; 30–50 IU/dL) is a common clinical phenotype associated with bleeding, but its genetic basis remains poorly defined. We aimed to explore the contribution of rare and common variants to Low VWF and bleeding risk. Whole-exome sequencing was performed...

Longitudinal dynamics of gene expression and metabolomics in an aging population cohort

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudinal whole-blood gene expression and metabolite levels in 335 females over 8 year...

Lynch syndrome–associated urothelial carcinoma: clinical and molecular findings from a single-institution cohort

Lynch syndrome–associated urothelial carcinoma (LS-UC) is a rare and undercharacterized clinical entity. While FGFR3 alterations are well described in sporadic urothelial carcinoma, their prevalence and clinical implications in LS-UC remain unclear. We aimed to provide a comprehe...