University of Milan

Sociality and nesting strategy account for non-random associations between bees and their parasitic dipterans

Abstract Bees (Apoidea: Anthophila) are recorded as common hosts of a diverse array of parasitic Diptera species, but information is widely scattered across the literature, limiting our knowledge of global bee-dipteran association patterns. Here, we retrieved published informatio...

Real‐world outcomes of venetoclax plus hypomethylating agents in unfit acute myeloid leukaemia: Results of the GIMEMA AML2320 trial

Summary Venetoclax (VEN) plus hypomethylating agents (HMAs) represents the standard of care for newly diagnosed acute myeloid leukaemia (AML) patients unfit for intensive chemotherapy, but prospective real‐world observational data outside randomized clinical trials remain limited...

Self-Signaling and the Anonymity Norm: A Quasi-Natural Field Experiment on Identity-Based Altruism

Abstract Contrary to standard models of indirect reciprocity, Muslim donors prefer anonymous donations and out-group causes rather than public and in-group ones. This study investigates the Western context. It examines whether the self-signaling behavior of Western Muslim donors...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Spheroid cultures reveal cancer stem cell enrichment and distinct chemotherapeutic response in triple-negative breast cancer

Three-dimensional (3D) cancer spheroids mimic key morphological and biological features of solid tumors, providing a valuable model for evaluating drug responses. Here, we investigated whether intrinsic cancer stem cell composition and tumor subtype determine spheroid formation c...

The value of mortality data to advance learning and decision-making dynamics in Mozambique’s health system

Abstract Introduction There is a lack of evidence on whether and how health systems stakeholders in Mozambique learn from routine health data. Despite the recurring claim by the stakeholders themselves that data in general should be the centre of informed public health policy, it...

The memory metaphors held by ordinary people: an exploratory study

Metaphors are widely used by researchers to communicate ideas in cognitive psychology. This is the first study to systematically explore the naïve psychology of human memory metaphors. We attained this goal by surveying a large sample of the adult population resident in Northern...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Polynomial Prethermal Lifetimes in Non Smoothly Driven Quantum Systems

Abstract We study the dynamics of a quantum many-body lattice system with a local Hamiltonian subjected to a quasi-periodic driving with finite regularity. For sufficiently large driving frequencies, we prove that the system remains in a prethermal state for times growing polynom...

When the Law Changes Therapy: Interrupted Time-Series Analysis of the Regulatory Impact on Intravenous Analgesic Consumption in 2 Italian Orthopaedic Hospitals (2021-2024)

Objectives: Tramadol is a centrally acting weak opioid widely used for moderate postoperative pain in orthopaedic surgery, so its regulatory status is directly relevant to hospital pharmacists. In November 2022 the Italian Ministry of Health reclassified tramadol as a controlled...

Logarithmic prismatic cohomology, motivic sheaves, and comparison theorems

Abstract We prove that (logarithmic) prismatic and (logarithmic) syntomic cohomology are representable in the category of logarithmic motives. As an application, we obtain Gysin maps for prismatic and syntomic cohomology, and we explicitly identify their cofibers. We also prove a...

Revisiting the productide (Productidina, Strophalosiidina) brachiopod fauna from upper Visean (Mississippian) reefs in Belgium and UK: systematics, palaeoecology and evolutionary implications

The Asbian (upper Visean, Mississippian) reefs of North Yorkshire, Derbyshire (UK) and Visé (Belgium) host rich brachiopod faunas studied since the 19th century. This paper revises the productide brachiopods, which dominate the benthic assemblages in both abundance and diversity....

A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy

BACKGROUND: Type 2 diabetes (T2D) is a complex chronic disease often associated with other metabolic conditions that increase the risk of cardiovascular (CV) disease and early mortality. Hence, early, integrated management of T2D may prevent long-term CV complications. METHODS: T...

Comparison of LC–MS/MS and CLIA Methods for Vitamin D Measurement in an Unselected Outpatient Cohort: Statistical Evaluation and Impact on Clinical Classification

Background: This study aimed to compare a chemiluminescence immunoassay (CLIA; Siemens Atellica IM 1600) with an automated liquid chromatography–tandem mass spectrometry (LC–MS/MS) analyser (Thermo Scientific Cascadion SM) for serum 25-hydroxyvitamin D [25(OH)D] measurement in un...

Operation Melilli, forensic humanitarian medico legal activities on the largest known Mediterranean disaster: the shipwreck of April 18th, 2015

On April 18th, 2015, a boat carrying about 1,000 migrants sank in the Strait of Sicily, prompting one of the most complex recovery missions ever conducted in the Mediterranean. Operation Melilli was the first time a European Government authorized the recovery of a sunken migrant...

Non– AIDS ‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

People with HIV (PWH) are living longer, but contemporary data on non-AIDS-defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow-up was grouped into 2000-2007...

The consequences of mitochondrial dysfunction and upregulated glycolysis on innate and adaptive immune responses

Mitochondrial dysfunction occurs in response to a variety of causes. It leads to partial or complete inhibition of oxidative phosphorylation and, consequently, to the upregulation of fermentative glycolysis which remains the main or only energy-producing pathway. Mitochondrial dy...

Surface Functionalization of Small Extracellular VesiclesDerived from Caco-2 and HEK293T Cells in the Neutralizationof Shiga Toxin 1 Subunit B

Abstract Shiga toxins (Stx) are key virulence factors of Shiga toxin-producing Escherichia coli (STEC), which are responsible for severe foodborne infections that can progress to hemolytic-uremic syndrome (HUS). Currently, no specific antitoxin therapies are available. In this st...

Visceral-to-subcutaneous fat ratio is a time-stable predictor of survival and toxicity in advanced hepatocellular carcinoma

Abstract Purpose Nutritional status significantly impacts the prognosis of patients with hepatocellular carcinoma (HCC). Computed tomography (CT) has become a key tool for assessing body composition (BC), with abnormal patterns increasingly linked to reduced survival. However, BC...

Forensic evidence from a 30-year study of non-thrombotic pulmonary embolism

Non-thrombotic pulmonary embolism (NTPE) represents a heterogeneous and underrecognized group of conditions characterized by the obstruction of the pulmonary vasculature by non-thrombotic material, often associated with complex pathogenetic mechanisms and non-specific clinical pr...