University of Milan

Logarithmic prismatic cohomology, motivic sheaves, and comparison theorems

Abstract We prove that (logarithmic) prismatic and (logarithmic) syntomic cohomology are representable in the category of logarithmic motives. As an application, we obtain Gysin maps for prismatic and syntomic cohomology, and we explicitly identify their cofibers. We also prove a...

Comparison of LC–MS/MS and CLIA Methods for Vitamin D Measurement in an Unselected Outpatient Cohort: Statistical Evaluation and Impact on Clinical Classification

Background: This study aimed to compare a chemiluminescence immunoassay (CLIA; Siemens Atellica IM 1600) with an automated liquid chromatography–tandem mass spectrometry (LC–MS/MS) analyser (Thermo Scientific Cascadion SM) for serum 25-hydroxyvitamin D [25(OH)D] measurement in un...

Non– AIDS ‐Defining Cancer Incidence in People With HIV in Milan, Italy, 2000–2023: Temporal Trends and Comparison With the General Population

People with HIV (PWH) are living longer, but contemporary data on non-AIDS-defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow-up was grouped into 2000-2007...

Operation Melilli, forensic humanitarian medico legal activities on the largest known Mediterranean disaster: the shipwreck of April 18th, 2015

On April 18th, 2015, a boat carrying about 1,000 migrants sank in the Strait of Sicily, prompting one of the most complex recovery missions ever conducted in the Mediterranean. Operation Melilli was the first time a European Government authorized the recovery of a sunken migrant...

The consequences of mitochondrial dysfunction and upregulated glycolysis on innate and adaptive immune responses

Mitochondrial dysfunction occurs in response to a variety of causes. It leads to partial or complete inhibition of oxidative phosphorylation and, consequently, to the upregulation of fermentative glycolysis which remains the main or only energy-producing pathway. Mitochondrial dy...

Surface Functionalization of Small Extracellular VesiclesDerived from Caco-2 and HEK293T Cells in the Neutralizationof Shiga Toxin 1 Subunit B

Abstract Shiga toxins (Stx) are key virulence factors of Shiga toxin-producing Escherichia coli (STEC), which are responsible for severe foodborne infections that can progress to hemolytic-uremic syndrome (HUS). Currently, no specific antitoxin therapies are available. In this st...

Forensic evidence from a 30-year study of non-thrombotic pulmonary embolism

Non-thrombotic pulmonary embolism (NTPE) represents a heterogeneous and underrecognized group of conditions characterized by the obstruction of the pulmonary vasculature by non-thrombotic material, often associated with complex pathogenetic mechanisms and non-specific clinical pr...

Visceral-to-subcutaneous fat ratio is a time-stable predictor of survival and toxicity in advanced hepatocellular carcinoma

Abstract Purpose Nutritional status significantly impacts the prognosis of patients with hepatocellular carcinoma (HCC). Computed tomography (CT) has become a key tool for assessing body composition (BC), with abnormal patterns increasingly linked to reduced survival. However, BC...

Cholesterol nose-to-brain delivery as a possible therapeutic strategy in Huntington’s disease

Abstract Background Huntington’s disease (HD) is a genetically dominant neurodegenerative disorder characterized by several pathological mechanisms, including the disruption of brain cholesterol homeostasis. In several HD animal models, brain cholesterol biosynthesis and levels a...

The Orbitofrontal Expansion for Extending Nasoseptal Flap Reach in the Frontal Sinus

Abstract Skull base defects involving the superior and lateral posterior table of the frontal sinus are challenging to reconstruct due to limited surgical access and restricted reach of available reconstructive options. External approaches are often required, increasing morbidity...

Microfragmented Adipose Tissue in Pain Management: Bridging Regenerative Biology and Clinical Therapeutics

Regenerative medicine has emerged as a transformative paradigm in contemporary healthcare, shifting the therapeutic focus from symptomatic management toward the restoration of tissue structure and function through biologically active interventions. Within this framework, adipose-...

Fiberoptic endoscopic evaluation of swallowing in neurogenic oropharyngeal dysphagia in adults: Part 2 of a scoping review

PURPOSE: The main objective of this scoping review was to describe the qualitative and quantitative parameters of fiberoptic endoscopic evaluation of swallowing (FEES) protocols, including their operational definitions and scales used in adults with neurogenic oropharyngeal dysph...

Iron oral supplementation in anemic patients undergoing orthopedic prosthetic surgery: a randomised trial comparing short_term and prolonged administration regimen

Preoperative anaemia in patients undergoing major elective orthopaedic surgery is a relatively frequent condition and is associated with perioperative transfusions. The aim of the present study was to investigate the efficacy of liposomal iron, folic acid, and vitamins in reducin...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...

Collective Risk Measures for Processes

Abstract This paper develops a comprehensive framework for collective risk measures, tools designed to quantify the aggregate risk stemming from a collective of agents. Crucially, these measures explicitly account for inter-agent cooperation, allowing agents to exchange risk thro...

Exploring Sustainability Reporting in the Fashion Industry Towards European Sustainability Reporting Standards: Evidence on ESRS Readiness

ABSTRACT In recent years, companies have increasingly sought to strengthen their sustainability commitment and reporting practices, particularly in industries with significant environmental and social impacts, such as fashion. The completeness and quality of sustainability report...