University of Milan

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria

Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality...

Pd-Catalyzed Reductive Cyclization Using CO Surrogates: Selective N–N Bond Formation and Access to Indazolo[3,2- a ]isoquinolines

A Pd-catalyzed reductive cyclization of nitroaryl isoquinolines using phenyl formate as a carbon monoxide (CO) surrogate is reported. The method provides selective access to 5,6-dihydroindazolo[3,2-a]isoquinolines, indazolo[3,2-a]isoquinolines, and 8,13-dihydro-7H-indolo[2',3':3,...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Transarterial embolization in inflammatory arthritis: will rheumatology shape the debate or inherit it?

Abstract The expanding use of transarterial embolization for musculoskeletal pain, most commonly operationalized as genicular artery embolization in osteoarthritis, raises a broader question that rheumatology has not yet systematically addressed: might a vessel-targeted, image-gu...

Sphingolipid signatures at the extremes of energy balance: a comparative study of obesity and anorexia nervosa in women

Background Anorexia nervosa (AN) and obesity (OB) represent opposite extremes of energy balance and are both associated with profound metabolic alterations. Increasing evidence suggests that sphingolipids play a central role in cardiometabolic regulation, inflammation, and insuli...

The “other Sixty-Eight”. Historical and cultural roots of far-right music in Italy (1968-1977)

Abstract The article aims to explore the origins of far-right music in Italy and its contribution to the formation of a new and corresponding youth movement, which constitutes a phenomenon at least partly independent of the historical and political legacy of the Fascist regime. T...

Digital solutions for tackling mental health in cancer patients and their families: The ALTHEA project

Despite advances in cancer treatment, the growing global cancer burden underscores the need for comprehensive and supportive care to address the needs of patients and their families. However, access to psycho-oncological support remains often limited across healthcare systems. Th...

Use of Tamoxifen Derivatives in Combination with Colistin against Colistin-Resistant Acinetobacter baumannii

Abstract Drug repurposing has led to the identification of tamoxifen, a well-known chemotherapy drug, as a compound with relevant antibacterial properties. In this field, the development of new tamoxifen derivatives with antimicrobial activity, particularly against colistin-resis...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

A scalable Zebrafish Platform for genetic validation and functional discovery of stage-specific breast cancer metastasis regulators

Metastatic disease accounts for over 90% of breast cancer-related deaths, yet scalable in vivo models for functional analysis of distinct metastatic steps remain limited. Here we show that an optimized zebrafish xenotransplantation platform enables quantitative, stage-resolved an...

On the Lavrentiev Gap for Manifold-Valued Maps

Abstract We characterize necessary and sufficient conditions ensuring approximation by smooth maps in the Sobolev space $$W^{1,\varphi }$$ W 1 , φ between suitable compact manifolds, where the prototypical example of Young function $$\varphi $$ φ is the double-phase integrand.

HIV breakthrough infection after 6 years of daily TDF/FTC oral PrEP with objectively documented optimal adherence

Oral Pre-Exposure Prophylaxis (PrEP) is highly effective for HIV prevention when adherence is optimal, with rare HIV breakthrough infections usually happening within 1–2 years since PrEP start. After 6 years of daily PrEP, routine HIV testing identified seroconversion in a 46-yea...

Conservative Management of Pediatric Mandibular Condylar Fractures: A Systematic Review

ABSTRACT Mandibular condylar fractures are common mandibular injuries in children. Conservative treatment is generally favored because of the remodeling capacity of the growing condyle, although rehabilitation protocols and the criteria for operative treatment remain variable. Th...

Delayed Arm Retraction Controls the Nonlinear Oscillatory Response of Long-Chain-Branched Polymer Melts

Abstract Long-chain branching profoundly modifies the nonlinear oscillatory response of entangled polymer melts by introducing arm-retraction pathways absent in linear polymers. We present a molecular tube theory that explains the characteristic maximum of the Nonlinearity Index...

A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells

Systematic strategies for identifying and classifying variants that directly modulate ribosome engagement are lacking. Here, we develop and extensively validate a pipeline to identify translation-associated single-nucleotide polymorphisms (tranSNPs) by integrating analysis of tot...

Computational identification and experimental validation of early glycinergic impairments in spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disorder characterized by lower motor neuron (MN) loss, due to mutations or deletions in the Survival Motor Neuron 1 ( SMN1 ) gene. Increasing evidence implies mitochondrial dysfunctions in SMA, suggesting these org...

21-Gene recurrence score assay in pN2-3 Early-Stage breast cancer: a national cancer database study

BACKGROUND: The clinical utility of the 21-gene recurrence score (RS) for guiding adjuvant chemotherapy in patients with pN2-3 early-stage breast cancer (eBC) has not been evaluated in prospective trials. This study aims to assess adjuvant chemotherapy benefit in patients with pN...

Everything you always wanted to know about sleep, but you were afraid to ask: expert concise guide and recommendations on assessing sleep-wake disturbances within a psychiatric context in contemporary times

OBJECTIVE: While disrupted sleep has long been linked to mental disorders there has been a notable decrease in interest and sleep-wake disorders have received low priority in psychiatric care. The aim of the paper was to present a concise guide for evaluating common sleep-wake di...