University of Milan

The collective bargaining challenges. The role of employers’ collective action in regulating the economy

In this article, we observe how employers are facing global and local challenges, which are often seen in IR literature as factors causing significant changes for businesses, workers, and consequently their representative associations. We observe that the logic of membership and...

A physics-informed neural network approach to diffusion and auto-oxidation in Fricke gel dosimeters

Precise dose quantification is critical for advanced radiation-based medical applications, particularly in emerging high dose-rate and mini-beam therapies. Fricke gels (FGs) are promising tissue-equivalent dosimeters based on the radiation-induced oxidation of \(Fe^{2+}\) to \(Fe...

Clinical evaluation of AI-assisted quantitative marrow fibrosis assessment using Continuous Indexing of Fibrosis (CIF)

Abstract Assessment of fibrosis is central to the evaluation of diagnostic bone marrow trephine (BMT) biopsies. However, manual fibrosis grading is subjective and only semi-quantitative. We evaluated the clinical utility of a previously developed AI-based quantitative fibrosis as...

Circulating tumor DNA-guided de-escalation or escalation of adjuvant therapy in high-risk stage II and stage III colon cancer: the phase 2 PEGASUS trial

Oxaliplatin–fluoropyrimidine combinations are standard adjuvant therapy after radical resection of high-risk stage II and stage III colon cancer but expose many patients to toxicity while failing to prevent relapse in others. PEGASUS was a multicenter, single-arm, phase 2 trial e...

Research Study Attrition and Participant-Informed Retention Strategies Among Cancer Survivors

Importance Attrition in longitudinal cancer cohorts compromises data completeness, introduces bias, and limits generalizability. Objective To quantify nonresponsiveness over time in a contemporary cohort of cancer survivors, identify individual- and center-level factors associate...

Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Background: Facioscapulohumeral muscular dystrophy (FSHD) is a progressive and heterogeneous disorder lacking reliable circulating biomarkers for disease monitoring and therapeutic response. We hypothesized that metabolic dysregulation, lipotoxicity, and endoplasmic reticulum (ER...

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

Abstract Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I 3 LUNG ( NCT05537922 ) is currently the...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Association of three different dietary patterns with the metabolomic profiles of children: the BiomarKid project

Abstract Background and aims Metabolomics offers a promising approach to objectively assess food intake and nutrition-related health risks. Three different dietary patterns (DPs) associated with cardiometabolic health were previously identified at 2 years of age in the EU Childho...

Paracetamol: A History of Assumptions, Errors, and Evidence Reversals in Pain Management

Abstract Purpose of Review Paracetamol (acetaminophen) is among the most widely used medications in the history of humanity for treatment of pain conditions. For more than half a century, it has occupied a unique position as the archetypal first-line analgesic and antipyretic, re...

A Remarkably Similar Oxygen Electronic Structure in CO-Treated CeO2 and Gd-Doped CeO2 Is Revealed by X-ray Raman Spectroscopy

Abstract CeO2 is a key material for catalytic and electrochemical applications due to its ability to store and release oxygen, linked to the formation of oxygen vacancies and the reversible reduction of Ce4+ cations to Ce3+. In this study, the oxygen K-edge was investigated in bu...

Assessing glymphatic role in the association between choroid plexus enlargement and white matter lesions load: The uncertain path through diffusion tensor imaging along the perivascular space (DTI-ALPS)

Background The choroid plexus (CP) is involved in cerebrospinal fluid production, immune surveillance, and brain fluid homeostasis. CP enlargement has been linked to neuroinflammation, glymphatic dysfunction, and white matter lesion (WML) burden, but the mechanisms underlying the...

Automated B-lines quantification with lung ultrasound in mechanically ventilated patients

BACKGROUND: If ultrasound dedicated software for the identification and quantification of interstitial syndrome is equal or superior to experts observation is still being explored. The primary objective of this study was to compare the performance of an automatic method based on...

Atomistic framework for glassy polymer viscoelasticity across twenty frequency decades

Glassy polymers are central to engineering applications, yet their viscoelastic response over broad frequency and temperature ranges remains difficult to characterize. We extend non-affine deformation theory by incorporating a time-dependent memory kernel within the generalized L...

Employees at risk within the “absent presence” paradox: a longitudinal comparison from non-smart to smart-working reward system in the Italian private/public sector

Purpose This contribution explores the evolution of employee motivation as a strategic asset in organisations. The objective is to investigate how the value of reward systems (monetary vs non-monetary) is changing in the era of the Smart Working Model (SWM), the paradoxes of the...

Emotion dysregulation in adolescents: comparing community and clinical samples and their association with mental health and risk behaviors

Abstract Background Emotion dysregulation (ED) is a multidimensional construct associated with mental health disorders, however, its distribution and clinical significance in the adolescent general population remain underexplored. This study aimed to investigate the prevalence an...

Development and Application of Computational Chemistry Methods

Computational chemistry has become an essential bridge between microscopic theory and measurable chemical behaviour [...]

Microbial adhesion promotes Piezo1 activation to initiate innate immunity

Abstract How mammals mount an effective immune response against infectious agents remains unresolved. Here we identify microbial adhesion to myeloid cells as a critical initiating event that precedes pattern recognition receptor (PRR) engagement. Using a skin infection model with...

Impact of postoperative pulmonary complications on survival after gastrectomy for cancer: individual patient data meta-analysis

Abstract Background Pulmonary complications (PC) may occur in up to 6.8% of patients after gastrectomy. Although PC are associated with prolonged hospital stay and increased overall healthcare costs, their impact on long-term survival remains controversial. This study aimed to an...

Dust Substructures and Line Perturbations driven by a Forming Planet in J16120

Abstract Hints of planet formation have been independently reported within the gap of the disc around 2MASS J16120668-301027 from millimetre continuum, infrared, and Hα observations. In this work, we present new evidence for ongoing planet formation based on Atacama Large Millime...