University of Milan

Early Introduction and Prolonged Full‐Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort

Background Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management. Methods We retrospec...

Liquid Biopsy-Guided Surgical Decision-Making in Oligometastatic Non-Small Cell Lung Cancer: Toward Dynamic Risk Stratification in the Multidisciplinary Era

Oligometastatic non-small cell lung cancer (NSCLC) is defined anatomically by a threshold of five or fewer metastatic lesions across three or fewer organs. That definition is a proxy for a biological question it cannot answer: whether the metastatic process has been arrested at a...

Volumetric Wear of Highly Cross-Linked Polyethylene Sockets in Total Hip Arthroplasty Differs Among Brands: A Retrieval Study

Outcomes after total hip arthroplasty (THA) remain limited by wear and wear particle reaction. Although highly cross-linked polyethylene (HXLPE) mitigated this issue, there are major differences among the various brands available. This study quantified, for the first time, the vo...

A nationwide student survey on biochemistry learning resources in Italy

Biochemistry is widely recognized as a crucial discipline in life sciences. However, learning biochemistry poses significant challenges, requiring students to understand complex molecular concepts while integrating knowledge across multiple disciplines. This necessitates instruct...

Turkey haemorrhagic enteritis live vaccination controls disease and field virus circulation: molecular, clinical and pathological evidence in field longitudinal studies

Haemorrhagic enteritis (HE) is a viral disease affecting turkeys. Live haemorrhagic enteritis virus (HEV)attenuated vaccines have recently been introduced in Italy. In this study, longitudinal field trials were conducted to assess the efficacy and safety of the live HE vaccine. T...

Impaired Flow and Physiology in Coronaries With Anomalous Origin From the Opposite Sinus of Valsalva

BACKGROUND: Anomalous Aortic Origin of a Coronary Artery (AAOCA) high-risk anatomical features (intramural segment, acute take-off angle, slit-like ostium) cause coronary stenosis leading to myocardial infarction. How these features alter coronary physiology remains unclear. AIMS...

Field-informed thermo-mechanical modelling of a full-scale energy quay wall

Energy quay walls (EQWs) represent an emerging class of energy geostructures that combine geothermal heat exchange with retaining-wall functions along waterways. While their thermal performance has been investigated in several recent studies, their thermo-mechanical (TM) behaviou...

Cosmological Constraints from Full-scale Clustering and Galaxy–Galaxy Lensing with DESI DR1

Abstract We present constraints on cosmic structure growth from the analysis of galaxy clustering and galaxy–galaxy lensing with galaxies from the Dark Energy Spectroscopic Instrument (DESI) Data Release 1. Our analysis includes four samples drawn from the Bright Galaxy Survey (B...

Speed-Accuracy Dissociation in Fencing: Performance Fatigability Without a Detectable Decline in Touch Accuracy: An Exploratory Study

Background: It remains unclear whether physiological load affects fencing accuracy to the same extent as movement speed and whether a shortened protocol can reproduce the outcomes of a full repeated-sprint protocol. Methods: Ten fencers (foil/épée; 7 men, 3 women; 16–30 years) co...

Sampling Weights at Intermediate Temperatures is Optimal for Training Large Language Protein Models

Using a statistical mechanics framework, we investigate the parameter space of transformer models trained on protein sequence data. We sample the loss landscape at varying temperatures using Langevin dynamics to characterize the low-loss manifold and to understand the mechanisms...

Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study

Background Disease features in resistance to thyroid hormone beta (RTHβ), caused by THRB mutations, arise from insensitivity to thyroid hormone in tissues expressing thyroid hormone receptor (TR)β and from lifelong thyrotoxic effects in TRα1-expressing tissues, posing substantial...

ADHD Presentations and Severity in Adults: Psychometric Profiles, Psychiatric Comorbidities, and Emotional Dysregulation in Relation to Psychiatric Hospitalization

Background/Objectives: Attention-deficit/hyperactivity disorder (ADHD) in adults is heterogeneous in symptom presentation, severity, and comorbid psychopathology, yet systematic data from Italian clinical populations remain limited. Methods: In this retrospective, cross-sectional...

Joint Modeling of GD-1 and C-19 as Old Streams

Abstract DESI observational data for the GD-1 and C-19 streams are compared to stream simulations in an evolving multihalo potential of a Milky Way–like galaxy based on a cosmological Milky Way–like simulation. The number of subhalos decreases with time, and the subhalo-stream en...

Apparent Ca Test Positivity and Crossmatch Reactivity in Donkeys from Italy: Intraspecies and Horse–Donkey Compatibility

Blood group distribution and serological compatibility are poorly characterized in donkeys. We estimated the apparent Ca positive-test frequency in 84 domestic donkeys and assessed donkey–donkey and horse–donkey crossmatch reactivity. Ca typing was performed using a commercial eq...

Understanding histotripsy ablation safety: a systematic review of pre-clinical and clinical adverse events

Abstract Histotripsy is the first cavitation-based ablation modality. Given limited clinical experience, synthesis of pre-clinical and early clinical data is essential to guide safe adoption. A PubMed and SCOPUS search was performed focused on pre-clinical and clinical adverse ev...

A Survey on Rigorous Results for the Dynamics of Periodic FPU Chains

Abstract In this paper we review some analytic results on the dynamics of the FPU system. In the first part of the paper, having in mind that the FPU Hamiltonian and the Toda Hamiltonian are close to each other, we present some results on the action angle variables of the Toda sy...

A consortium-driven framework for biomarker prioritization in the HEBE aging study

Abstract Aging is a complex biological process influenced by chronic low-grade inflammation, oxidative stress, and metabolic dysregulation, collectively termed inflammaging. The HEBE (Healthy aging versus inflamm-aging: the role of physical Exercise in modulating the Biomarkers o...

On the Fragility of Burnt Osteological Fragments: Technical Assessment of Potential Loss of Material

ABSTRACT The analysis of burnt osteological fragments from archaeological and forensic contexts is a challenging area of research due to the fragmentary and often incomplete nature of these remains. Conservation and preservation are ongoing issues, since the thermally altered bon...

The adapted version of the volunteer function inventory to assess the community perspective of volunteer motivation

Psychological inquiry on volunteerism has widely implemented self-part studies on volunteers’ motivations via the Volunteer Function Inventory (VFI). The literature in psychology also has widely acknowledged the limitations of the self-report assessment and the need for clarifica...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...