University of Milan

Aflibercept 8 mg for diabetic macular edema and neovascular age-related macular degeneration: an italian expert consensus paper

To provide consensus recommendations on the clinical use of aflibercept 8 mg in managing neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) in the real-world setting. A modified Delphi study was undertaken, involving ophthalmologists from special...

Transcriptomic profile and endothelial changes during differentiation syndrome in acute promyelocytic leukemia

Abstract Acute promyelocytic leukemia (APL) is curable with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), but differentiation syndrome (DS) remains a potentially life-threatening complication, with poorly understood pathogenesis. We investigated clinical, molecular a...

Development of an inactivated, oral immunogenic product against post-weaning colibacillosis caused by enterotoxigenic Escherichia coli in piglets

Abstract Background Post-weaning diarrhea (PWD) caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 and F18 fimbriae remains a major challenge in pig production, contributing to economic losses and increased antimicrobial use. This study aimed to preliminary evaluate...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Assistive technologies (lumbar supports and other devices) for treating chronic low back pain

RATIONALE: Low back pain (LBP) is a major global health problem. It is the most common cause of activity limitation amongst individuals younger than 45 years, and one of the most frequent reasons for visits to a doctor. The 2019 Global Burden of Disease study named LBP as the lea...

Chronic pain in Italy: exploring patient perspectives on care gaps and opportunities

Abstract Background : Chronic pain represents a significant public health burden, yet comprehensive data on patient perspectives in Italy remain limited. Despite Law 38/2010 guaranteeing access to pain therapy, gaps persist in understanding how patients experience care, navigate...

Gravitational instability in planet-forming discs

During the earliest phases of star and planet formation, a young star is surrounded by a disc that can become gravitationally unstable. Indeed, if the protoplanetary disc is sufficiently massive, its self-gravity triggers the formation of large scale spiral arms, transporting ang...

Toward harmonized reporting of Alzheimer’s disease biomarkers in clinical practice

Abstract Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, thera...

Potential of temperate agroforestry systems to deliver ecosystem services: An evidence map

Abstract. Agroforestry systems are promoted as multifunctional land-use strategies, yet evidence of their benefits, especially in temperate regions, remains fragmented. This umbrella review maps 42 meta-analyses to quantify the effects of agroforestry on environmental, climate, a...

Oral Zinc Supplementation in Acne Vulgaris and Hidradenitis Suppurativa: An Updated Comprehensive Review

Oral zinc supplementation has emerged as a potential ⁠adjunctive strategy in inflammatory follicular disorders, including ⁠acne vulgaris and hidradenitis suppurativa. Beyond its role as an essential micronutrient, zinc modulates several pathways and biological processes directly...

Thermodynamic formulation of Cotton gravity in the Codazzi parametrization

Abstract We develop a thermodynamic formulation of Cotton gravity in the Codazzi parametrization, providing a general framework in which the gravitational dynamics can be interpreted in terms of horizon thermodynamics. As paradigmatic examples, we apply the formalism to Friedmann...

Ligand binding free energy landscapes at the tubulin colchicine site from coarse-grained metadynamics

Accessing deeply buried binding sites remains a major challenge in structure-based drug discovery, where accurate description of both protein dynamics and ligand binding pathways is required. All-atom funnel metadynamics (AA-FMD) enables simulation of complete binding processes b...

Second ipsilateral locoregional recurrence in patients with hormone receptor-positive, HER2-negative breast cancer: a cohort study

Background Evidence regarding outcomes in patients with hormone receptor (HR)-positive/HER2-negative breast cancer (BC) with a second consecutive ipsilateral locoregional recurrence (LRR) remains limited. Methods Single-center, cohort study including consecutive patients with HR-...

Shape coexistence in 94Zr from a model-independent analysis

Low-lying states of 94Zr were investigated via low-energy multi-step Coulomb excitation. From the measured γ-ray yields, 16 reduced E2 transition probabilities between low-spin states were determined, together with the spectroscopic quadrupole moments of the 2+1,2 states. Based o...

Allelopathy and Allelochemicals: Sources, Mechanisms of Action, and Their Role in Integrated and Sustainable Crop Protection

Allelopathy is an ecological process in which released chemicals modify the performance of neighbouring organisms, whereas phytotoxicity describes an inhibitory response to a substance under a defined assay and, by itself, does not demonstrate field-level allelopathy. This critic...

Co-occurrence of high levels of deformed wing virus genotype A and B in both managed and wild social bees

Abstract Bees are key pollinators that support global food production and plant biodiversity, yet wild pollinator populations are declining due to anthropogenic pressures, including habitat loss, pesticide use, and emerging disease. In honey bees ( Apis mellifera ), viral disease...

Early‐Life Telomere Length Negatively Covaries With Brood Size and Father Age, and Predicts Long‐Term Survival in Male Barn Swallows ( Hirundo rustica )

Parental decisions on breeding, such as brood size and timing of reproduction, influence the early-life environment of the offspring, exposing them to variable levels of stressors, which in turn may affect their fitness. In this context, telomeres, conserved DNA sequences at chro...

Bone marrow–derived thrombospondin-1 programs tumor cell dormancy via CD47–integrin αvβ3 axis

Dormant disseminated tumor cells are responsible for late metastatic relapses, a current clinical challenge. This study investigates the microenvironmental signals that maintain breast cancer cell quiescence in the bone marrow. 4T1.2-CVp27 cells, engineered to enable quiescence d...

Phenotyping iPSC-derived neurons from Angelman patients and partial rescue via JNK pathway inactivation

Angelman Syndrome (AS, MIM #105,830) is a rare neurodevelopmental disorder caused by imprinting defects, and it is marked by motor impairment, intellectual disability, speech limitations, and seizures. The condition arises due to the loss of function in neurons of the maternally-...

A nicotinic-dopaminergic hybrid probe enhances D2-like autoreceptor-mediated inhibition of dopamine release

β2-containing nicotinic acetylcholine receptors (nAChRs) and dopamine D 2 receptors (D 2 Rs) cooperate to shape striatal dopamine (DA) output, yet the mechanisms by which nicotinic-dopaminergic crosstalk influences D 2 -like autoreceptor-mediated inhibition of DA release remain u...