University of California, Los Angeles

The Circle That Remembers, the Interval That Forgets: GG-Theory and the Sixteen Problems of Particle Physics and Cosmology

Physics keeps a short list of questions its own tools cannot close: what happens when a measurement happens; where the Standard Model's two dozen unexplained numbers come from; what launched the Big Bang; what became of the information that fell into a black hole. Their median ag...

GDOS: Geometric Dynamics of Open Systems: 6D GG-6 Bulk Projected to 4D Boundary for Quantum Measurement, General Relativity, and QFT

Every system in nature is open. No real system has ever been isolated. Indeed, the very act of observation already presumes that observer and observed are coupled. Yet for three and a half centuries, the foundational theories of physics have been written as if isolation were the...

Characterising caregivers’ contingent responses: Short, slow, and clear speech facilitates infant turn-taking

Bidirectional temporal contingency in infant-caregiver interaction is believed to be instrumental in shaping the development of turn-taking and speech. Likewise, caregivers are known to modulate their voices in a distinctive register when speaking to infants. Yet, less is known a...

The filtration performance of fabrics against particles of viral size: a systematic review

Wearing a mask is part of the comprehensive strategy to suppress transmission of the SARS-CoV-2 virus and respiratory tract infections. Despite available COVID-19 vaccines, wearing a mask has remained one of the simplest and most effective ways. There was, however, little data av...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Development and Reliability Testing of the Sinonasal Assessment of Reepithelialization, a Novel Wound Healing Scale to Assess Postoperative Healing

ABSTRACT Background Sinus and skull base surgery create areas of demucosalized bone and cartilage in the sinonasal cavity, yet no standardized system exists to describe the progressive healing of these wounds. The goal of this study was to develop the novel Sinonasal Assessment o...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

Expert Perspectives on TGCT and the Outcomes of the Phase 3 MANEUVER Study of Pimicotinib Presented at ASCO and ESMO 2025: A Podcast Discussion

Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive neoplasm that significantly impacts patients’ quality of life through pain and swelling of the affected joint, resulting in limited range of motion. TGCT is categorized into two radiographic subtypes (localized an...

Viscosity of NaAlSi3O8−H2O fluids and implications for arc magmatism

Water plays a crucial role in the transport properties of silicate liquids and is especially important in subduction-zone magma source regions where conditions promote complete miscibility between water and silicate melts. However, accurately tracing the movement of fluids and vo...

Strategic design of methane observation networks to improve emission estimates: A case study in Africa

Abstract. Ground-based and satellite atmospheric observations are essential for reducing uncertainties in methane (CH4) emissions by atmospheric inversion, particularly in data-sparse regions such as Africa. However, adding new observation sites does not yield linear improvements...

Thermal bottlenecks constrain early-life survival of native fish in regulated rivers

Climate change is reshaping thermal regimes worldwide, threatening species whose early development depends on narrow temperature ranges. Yet directly linking warming to reproductive failure in wild populations remains intractable, particularly in aquatic ecosystems. We developed...

Association between exposure to air pollution and age at natural menopause: The Study of Women's Health Across the Nation.

CONTEXT: Air pollution is a recognized risk factor for women's subfertility, yet its association with the timing of natural menopause remains understudied. OBJECTIVES: To examine the association between exposure to ambient air pollution and age at natural menopause (ANM). DESIGN...

Comparative Analysis of Ion and Electron Contributions to Ionospheric Ionization at Auroral and Subauroral Latitudes

Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...

A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures

Abstract It is increasingly recognized that genetic effects on complex traits and diseases are shaped by environmental context. Biobanks that measure diverse environmental exposures alongside genotypes and phenotypes at scale enable systematic study of gene-environment (G×E) inte...

Acromial Stress Fractures in Reverse Total Shoulder Arthroplasty: Diagnosis, Prevention, and Treatment

PURPOSE OF REVIEW: This review critically evaluates the literature on acromial stress fractures (ASFs) following reverse total shoulder arthroplasty (rTSA), with a focus on risk factors, prevention, and treatment. By synthesizing contemporary evidence and highlighting areas of on...

An ex vivo gut mucosal explant assay to compare HIV tissue susceptibility shows increased HIV susceptibility with methamphetamine exposure

Background: mucosal explant models for HIV assess viral replication but do not fully capture the ability of tissue to support productive infection and transfer to target cells, an important indicator of tissue susceptibility. Additional tools to investigate relative mucosal susce...

Ancestry and Kawasaki Disease: Clinical Pathway Considerations

Kawasaki disease (KD) is the leading cause of pediatric acquired heart disease in developed countries.1 Despite decades of research, no established biologic marker has been identified, and KD remains a clinical diagnosis.1,2 However, KD research has shown that different populatio...

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

Purpose To characterise regional and topographic choroidal thickness (CT) profiles using ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) and to compare topographic CT between normal eyes and eyes with pachychoroid disease. Methods All participants underwent...

Simulating exciton transport with complex absorbing potentials

We introduce a stochastic framework based on complex absorbing potentials (CAPs) to investigate exciton transport in large molecular aggregates. Within this framework, CAPs act as non-Hermitian reservoirs and sinks, enabling an effective assessment of transport efficiency. We app...