Sun Yat-sen University

A Dual‐Regulation Strategy Enables Broadly Tunable Multiband Emission in Organic–inorganic Hybrid Rare Earth Halide Glass toward Dynamic Information Encryption

ABSTRACT Tunable multiband luminescence across a broad spectrum in a single transparent glass is highly desirable for advanced optoelectronics. However, this goal remains challenging in conventional inorganic glass systems, which are plagued by low doping concentrations of lumine...

Short-Term Exposure to Ambient Air Pollution and Hospital Admission for Stroke: A Multi-Center Hospital-Based Case-Crossover Study

Stroke is a leading cause of death and disability worldwide. Exposure to ambient air pollutants and the risk of stroke have been reported in many studies, but the results vary greatly among different regions. This study aims to investigate the association between short-term expos...

Cancer drug response and resistance: molecular mechanisms and combating strategies

Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...

The VASN-YAP-MYL9 axis drives M2-like macrophage polarization and immune evasion in colorectal cancer

Tumor-associated macrophages (TAMs) polarized toward an M2-like phenotype are critical drivers of immunosuppression in colorectal cancer (CRC). While Vasorin (VASN) is implicated in poor prognosis, its specific role in orchestrating the tumor immune microenvironment remains elusi...

Mitochondria‐Targeted Re (I) Complex Triggers Cuproptosis and Pyroptosis by Regulating Copper/Zinc Homeostasis in Cancer Cells

ABSTRACT Copper and zinc homeostasis is tightly regulated in mammalian cells, and their dysregulation is implicated in various pathological conditions including cancer. Herein, we have designed rhenium (I) complexes with Cu 2+ and Zn 2+ chelating properties, exhibiting significan...

Genetic diversity, haplotype structure, and population dynamics of Echinococcus granulosus isolates from human cystic echinococcosis in Tibet, China

Cystic echinococcosis (CE) is a globally important zoonotic disease caused by the larval (metacestode) stage of Echinococcus granulosus (sensu lato), a parasite complex characterized by marked genetic heterogeneity across geographical regions. The Tibet Autonomous Region (TAR) of...

Measured resting energy expenditure via indirect calorimetry of critically ill patients: A comparison with predictive equations.

BACKGROUND AND OBJECTIVES: Assessing the resting energy expenditure (REE) of critically ill patients is essential for individual nutritional programs. We hypothesized that different evaluated ways for REE can be compared, and REE may be associated with disease severity and clinic...

Embedding architectural prototype knowledge in interpretable deep learning for morphological similarity evaluation of traditional villages

Prototypes are inherited spatial rules that allow village morphology to persist through migration while adapting to local environments. Conventional studies of village morphology remain limited in large-scale comparison. Although remote-sensing-based deep learning enables large-s...

Enhanced acetate uptake and metabolism in endothelial cells promote tumour angiogenesis and immunosuppression by increasing histone acetylation

Background Acetate is the metabolic precursor of acetyl-coenzyme A (CoA), fuelling histone acetylation. Objective We aimed to investigate whether the acetate-acetylation axis is hijacked in tumour endothelial cells (TECs) to govern hepatocellular carcinoma (HCC) progression. Desi...

IL10RB-AS1 promotes pro-caspase-1-dependent pyroptosis via regulating the oligomerization and nucleation of CARD8 C-terminal domain to suppress acute myeloid leukemia

Abstract CARD8 (caspase activation and recruitment domain-containing 8) senses intracellular danger signals, leading to inflammasome formation and pyroptosis. Recently studies have shown that CARD8 was highly expressed in hematopoietic cells, however, the mechanism by which the r...

The diagnostic value of cardiovascular magnetic resonance in hypertrophic cardiomyopathy

Limited studies compare the clinical applications and diagnostic values of cardiovascular magnetic resonance (CMR) versus echocardiography in individuals with hypertrophic cardiomyopathy (HCM). This study was performed to evaluate the diagnostic value of CMR in patients with HCM....