Sun Yat-sen University

Intelligent Governance of Complex Social Systems: A Hybrid AI–System Dynamics Model for the Simulation and Projection of Sustainable Energy Transition

Amidst growing uncertainty regarding global sustainable development goals and the increasing complexity of social systems, accurately characterizing long-term transition processes driven by the interactions of multiple agents and factors remains a critical challenge. Using China’...

Decentralized Solar-Driven Plant Factories Secure an Adequate Global Vegetable Supply beyond the Electricity Grid and Water Limitations

Abstract Conventional open-field vegetable production is increasingly constrained by climate volatility and natural resource endowments, creating supply instabilities and shortages that threaten global food resilience and human health. Here, we integrate solar photovoltaics and a...

A scene-mapped framework for deriving clear-sky surface longwave downward radiation from remotely sensed measurements

Accurate estimation of clear-sky surface longwave downward radiation (LWDR) is fundamental to surface energy budget studies, yet widely used parameterizations and conventional lookup-table (LUT) searches often suffer from regional biases and limited transferability. This study de...

Three-decade trends in nonalcoholic fatty liver disease across 204 countries and territories

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading chronic liver disease globally, driven by the rising incidence of obesity, type 2 diabetes, and metabolic syndrome. Despite the increasing burden, most studies focus on prevalence rather than incidence, leaving a g...

Placenta-Related PEG10 Inhibits mRNA Decay to Promote Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma

Abstract Tumors display marked similarities with embryos, exploiting embryonic developmental programs. Beyond the embryo, the placenta also shares features with malignant tumors, such as invasion, immune evasion, and rapid nutrient exchange, highlighting the need for mechanistic...

Staged Multi-step UTXO Workflows via Recursive Invariants

Stateless UTXO-style execution validates transactions using local and referenced data, enabling parallel validation and predictable serialized-size/weight accounting. However, multi-step workflows must thread state across outputs, and a prepared next-step transaction may become s...

From Static to Dynamic: Benchmarking Real-World Code Review with MCR-Bench

In real-world software development, code review typically involves iterative interactions between developers and reviewers to improve software quality, making the process costly and time-consuming. Although recent work explores large language models (LLMs) for automated code revi...

Quantum kinetic theory for quantum chromodynamics

We develop a quantum kinetic theory for QCD, which incorporates all leading order collision terms. The diagonal components of the Wigner functions for quarks and gluons satisfy a spin-averaged Boltzmann equation. The non-diagonal components of the Wigner functions give spin polar...

Integrated Multi-Omics Profiling of Thymoma Identifies Subtype-Specific Remodeling and Myasthenia Gravis-Associated Targets

Abstract Thymoma is a rare thymic epithelial tumor strongly associated with myasthenia gravis (MG), yet the tumor intrinsic molecular states underlying this link remain unclear. Here, we profiled paired thymoma and distant nontumorous thymic tissues using untargeted metabolomics,...

Understanding and Improving Model Editing for Secure Code Generation

Large language models (LLMs) are widely used for code generation but may reproduce vulnerabilities learned from insecure training data. Prior work mainly relies on inference-time hardening, which introduces auxiliary components and runtime overhead. We present the first systemati...

An association of Liquidambar (Altingiaceae) vegetative and reproductive structures from the Miocene of South China

Liquidambar is a classic example of the eastern Asian–eastern North American biogeographic disjunction, and its fossil record is critical for understanding the evolutionary history and taxonomy of Altingiaceae. In particular, associated vegetative and reproductive fossils provide...

D-allose reprogrammes the mitophagy–mtDNA–cGAS–STING–ADM2 axis to restore nucleus pulposus cell homeostasis in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is driven by progressive loss of nucleus pulposus cell (NPC) homeostasis, yet the stress-responsive mechanisms governing this process remain incompletely defined. Here, we identify a mitochondrial stress-innate immune signalling axis in whi...

Risk Prediction Models and Predictors of Low Anterior Resection Syndrome in Patients with Rectal Cancer: A Systematic Review and Meta-Analysis

Objectives Identifying patients at high risk of low anterior resection syndrome (LARS) after rectal cancer surgery may facilitate early management and improve postoperative quality of life. Several LARS prediction models have been developed, but their predictive performance and m...

Data-driven modeling of Galactic diffuse emission with multi-wavelength observations

Abstract We present a data-driven investigation of Galactic diffuse emission. Using multi-frequency Planck maps (30–857 GHz), we construct a non-linear mapping between microwave-to-far-infrared and gamma-ray intensity through supervised machine learning. Our models achieve high p...

De Novo Discovery of Cysteine-Targeted Reversible Covalent Cyclic Peptides with Prolonged Residence Time via Phage Display

Abstract Reversible covalent targeting of cysteine residues offers a powerful strategy for generating potent and tunable ligands, but designing electrophiles with balanced reactivity, stability, and reversible binding remains challenging. Here, we systematically optimized reversi...

Tumor specific cytokine pattern explored in renal cell carcinoma

Renal cell carcinoma (RCC) is a common urological malignancy, yet the cytokine landscape of the tumor microenvironment, especially in early-stage tumors, remains poorly defined. Using antibody arrays, 174 tumor-related cytokines were measured in 20 sets of normal, para-cancerous,...

Haploidentical hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for severe aplastic anemia patients aged 40–65: a multicenter retrospective study

Abstract Immunosuppressive therapy (IST) plus eltrombopag (EPAG) (IST+EPAG) is the preferred first-line treatment for severe aplastic anemia (SAA) patients over 40 years. However, direct comparison between IST+EPAG and upfront haploidentical hematopoietic stem cell transplantatio...

The Piezo1/Ca²⁺/NOTCH2 axis mediates matrix stiffness-induced osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells

Human bone marrow-derived mesenchymal stem cells (hMSCs) are key seed cells with multi‑lineage differentiation potential, and their osteogenic differentiation capacity forms the basis of bone regeneration. Extracellular matrix stiffness acts as a potent biophysical cue directing...

Circulating RANKL is required for glucose homeostasis during pregnancy

Gestational diabetes mellitus (GDM) poses a significant health burden on women worldwide, necessitating the search for predictive, diagnostic and therapeutic approaches. Increasing evidence suggests that the receptor activator of NF-κB ligand (RANKL) is closely associated with GD...

Knowledge and attitudes about artificial intelligence and its applications among Chinese endodontic practitioners: a cross - sectional survey

Artificial intelligence (AI) has been increasingly applied in dentistry, including cariology and endodontics. However, evidence remains limited regarding endodontic practitioners’ AI literacy, perceptions, clinical usage, and barriers to AI integration. This study aimed to invest...