Sun Yat-sen University

Modeling the Impact of Active Site Mutations on the Quenching Fate and Cyclization Depth of a Rare Oxidosqualene Cyclase

Abstract Oxidosqualene cyclases (OSCs) convert linear 2,3-oxidosqualene into diverse polycyclic triterpenoids. The precise control over highly reactive carbocation intermediates, particularly the ultimate quenching mechanism (deprotonation vs hydroxylation), remains a fundamental...

Terrain‐Induced Contrasts in the Diurnal Variations of Low‐Level Jets Over the Middle Reaches of the Yangtze River During the 2010 Mei‐yu Field Campaign

Abstract The diurnal cycle of low‐level jets (LLJs) plays a crucial role in severe convective weather during the Mei‐yu season over the middle reaches of the Yangtze River (MRYR). However, previous studies have focused on individual sites or large‐scale climatic contrasts, leavin...

Spatiotemporal dynamics of rhizosphere soil water, temperature and salinity under various drip irrigation regimes and their effects on cotton biomass formation

Optimizing drip irrigation regimes is critical for managing the rhizosphere soil environment and enhancing cotton productivity in arid regions. A two-year field experiment (2023–2024) was conducted in northern Xinjiang, China, with four irrigation levels (60%, 80%, 100%, and 120%...

Moderate grazing enhances soil nutrient cycling in desert grasslands through microbial community assembly at the patch scale

Desert steppes are highly sensitive ecosystems, yet how long-term grazing regulates soil microbial assembly and ecological functions at the patch scale remains unclear. Using a 10-year in situ grazing experiment, we investigated microbial communities within native Stipa breviflor...

The dual role of fibrinogen in vascular permeability and alveolar senescence reveals its potential as a pharmacological target for asthma

Fibrinogen (Fg), a critical mediator in vascular and inflammatory diseases, is poorly understood in asthma pathogenesis. Here, our data support a model in which Fg acts as a dual-function driver of asthma progression through distinct endothelial and epithelial mechanisms, and we...

Follicular dendritic cell sarcoma in association with Castleman disease complicated by paraneoplastic pemphigus: a retrospective analysis of six cases

Abstract Background Follicular dendritic cell sarcoma (FDCS) arising from Castleman disease(CD) is an extremely rare entity. This study aimed to evaluate the detailed clinicopathological characterization, including histomorphology, immunohistochemical profiles, clinical presentat...

Association of hydroxychloroquine use with pregnancy outcomes in euthyroid TPOAb-positive women with unexplained recurrent pregnancy loss: a retrospective cohort study

Recurrent pregnancy loss (RPL) is a multifactorial disease. Approximately 40–60% of cases remain unexplained and are classified as unexplained recurrent pregnancy loss (URPL). Thyroid autoimmunity (TAI), particularly thyroid peroxidase antibody (TPOAb) positivity, has been implic...

Kirkendall Effect-Driven Construction of Hollow Rare-Earth Silicate Nanospheres for Drug Loading

Abstract Monodisperse oxide nanoparticles have attracted attention for biomedical applications. However, conventional synthetic methods often provide limited control over particle size, morphology, and polydispersity. Herein, we report a bottom-up strategy for synthesizing hollow...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

Decomposition of phengite from residual subducted slabs enhancing lithospheric tin mineralization: Insights from K–Li–Nd isotopes

The sources and roles of volatiles in tin (Sn)-related magmatic systems remain controversial. We present integrated K–Li–Nd isotopic, trace element, and volatile data from Late Cretaceous Xishan Sn-mineralized granites in the southern margin of the South China Block to constrain...

Bridging electrochemical desalination and energy storage: Coordination chemistry of organic electrode materials for capacitive deionization and aqueous batteries

Organic materials are attracting attention as tunable electrodes for capacitive deionization (CDI) and aqueous batteries, owing to their structural designability, abundant redox-active sites, and resource sustainability. This review systematically presents progress on three class...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

A new data-driven model for rapid urban low-level wind field simulation using conditional generative adversarial networks

Rapid and accurate representation of urban low-altitude wind fields is essential for understanding urban wind environments, assessing ventilation performance, and supporting emerging low-altitude aviation applications. Conventional computational fluid dynamics (CFD) provides reli...

Emerging compound air-soil heatwaves amplify global vegetation losses

Abstract Compound air-soil heatwaves—periods in which extreme air and soil temperatures co-occur—pose a growing threat to terrestrial ecosystems, yet their occurrence and impacts remain poorly understood. Here, we show that compound air-soil heatwaves have become more frequent (0...

Short-term neonatal in-hospital associations following delivery room ETI versus PPV resuscitation: a multicenter retrospective cohort study

Abstract Background Endotracheal intubation (ETI) and positive pressure ventilation (PPV) are core neonatal resuscitation interventions. Baseline clinical imbalances confound gestational-age (GA)-specific associations between ETI and in-hospital adverse events. We evaluated GA-st...

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts

TGF-β is a central driver of kidney fibrosis, a common pathological hallmark of chronic kidney disease (CKD). Initiation of TGF-β signaling requires not only its synthesis but also the conversion of latent TGF-β to its bioactive form. However, the mechanisms governing TGF-β activ...

Conceptual Interpretation and Practical Teaching Design of Ideal Work and Lost Work: Comments on Chemical Engineering Thermodynamics Textbooks

Abstract Ideal work and lost work are key contents connecting the second law of thermodynamics and engineering practice, and they pose major teaching challenges in chemical engineering thermodynamics courses. Mainstream textbooks widely use a two-step model including adiabatic re...

Integrating bioinformatics and experiments to identify neddylation-related prognostic features in prostate adenocarcinoma

Targeting neddylation represents a promising treatment strategy for prostate adenocarcinoma (PRAD). This study integrated bioinformatics and experimental approaches to identify neddylation-related prognostic genes in PRAD, with the goal of providing new insights. Public datasets...

Donor‐Site Outcomes of the Superficial Circumflex Iliac Artery Perforator Flap Versus Radial Forearm Flap in Unilateral Tongue Reconstruction: A Propensity Score Matching Analysis

ABSTRACT Background We compared the superficial circumflex iliac artery perforator (SCIP) flap with the radial forearm flap (RFF) to identify limitations restricting its widespread use. Methods We retrospectively evaluated unilateral tongue reconstruction using propensity score m...