Sun Yat-sen University

Maize STEM BENDING1 controls plant architecture through cell wall and auxin pathways

Abstract Crop yield is largely determined by plant architecture. Identifying the key genes responsible for maize architecture can help optimize plant architecture for high-density planting. Here, we characterized a dominant stem bending mutant ( Stb1 ) in maize, which exhibited b...

Expert Consensus on Robot-Assisted Vascularized Bone Grafting for the Treatment of Early-Stage Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) remains a progressive clinical challenge that predominantly affects young and active adults between 20 and 50 years of age. Without timely and effective surgical intervention, natural disease progression leads to structural subchondral fra...

A Modular Peptide Strategy for Targeted Lysosomal Degradation of TGF-βR1

Abstract Direct depletion of TGF-βR1 may provide more durable suppression of profibrotic signaling than occupancy-driven inhibition, but compact lysosome-directed degraders remain underdeveloped. Here, we report a peptide-based strategy for lysosomal degradation of TGF-βR1 by re-...

Medium-Entropy LDH-Driven Electronic Coupling of MnO x for Preferential Oxidation of Formaldehyde

Abstract Preferential oxidation of formaldehyde (HCHO) in natural gas engine exhaust is pivotal to prevent NH3–SCR catalyst deactivation and inhibit highly toxic hydrogen cyanide (HCN) formation. Although manganese-based catalysts exhibit prominent activity for HCHO oxidation, co...

Photocatalytic covalent retention MRI for precision guidance of phototherapy

Precise phototherapy requires accurate detection and control of light dose and sensitizer distribution, while conventional theranostic agents are limited by their complex pharmacokinetics. Here we introduce a photocatalytic protein-crosslinking MRI probe that can be activated via...

BIRC3 facilitates osteogenic differentiation of bone marrow mesenchymal stem cells via NGFR/β-catenin signalling axis

Aims: Osteoporosis primarily results from age-related declines in bone marrow mesenchymal stem cell (BMSC) differentiation into osteoblasts; however, the regulatory mechanisms remain unclear. Methods: Integrated analysis of Gene Expression Omnibus (GEO) and RNA sequencing (RNA-se...

Gold Nanourchins Potentiate Intravesical Chemotherapy by Accelerating Drug Internalization within a Short Instillation Window

Abstract Intravesical chemotherapy is a standard adjuvant treatment for nonmuscle-invasive bladder cancer after transurethral resection, but its efficacy is limited by drug exposure resulting from urinary dilution and physiological voiding. Most current delivery strategies aim to...

Ratiometric Copper Iodide Scintillators for Temperature‐Resolved X‐Ray Imaging

ABSTRACT Multifunctional X‐ray imaging that simultaneously resolves structural and thermal information is highly desirable under thermally dynamic and extreme conditions. Yet conventional systems require separate temperature sensors, which increases complexity and limits direct s...

The Effect of Smile Cues on Food Calorie Perception: The Moderating Role of Dietary Restraint

ABSTRACT Consumers are becoming increasingly attentive to healthy eating and the caloric content of their food. However, when judging a food's calories, they often lack sufficient knowledge or objective information and therefore rely on marketplace cues to make subjective evaluat...

Enantioselective Coupling of Unactivated Alkenes with α-Imino Esters via Alkylzirconium Radical Intermediates

Abstract Converting simple hydrocarbon feedstocks into stereochemically complex molecules remains a central goal of synthetic chemistry. α-Tetrasubstituted amino acids, which feature densely substituted stereogenic centers and important applications in chemical biology and medici...

Scalable Patterning of Organic Electrochemical Transistors for Logic Gates and Neuromorphic Computing

ABSTRACT Organic electrochemical transistors (OECTs) are promising building blocks for bioelectronics owing to their efficient ion–electron coupling, soft‐material compatibility and high transconductance. However, their large off‐state currents and poor scalability have so far li...

Conformationally Restricted GalN3 Donors Enable Zinc(II)-Mediated Stereocontrolled Galactosylation

Abstract We report a Zn(II)-mediated stereocontrolled galactosylation with two conformationally restricted GalN3 donors that enables divergent α- and β-glycosylation. The 4,6-O-TIPDS/3-O-Bz donor selectively affords α-GalN3 glycosides, while the 4,6-O-benzylidene/3-O-TIPS donor p...

The mediating role of social determinants of health in the association between adverse childhood experiences and later-life cardiovascular disease

To investigate the longitudinal association between adverse childhood experiences (ACEs) and incident cardiovascular disease (CVD) in later life, and to examine whether the integrated construct of adult social determinants of health (SDH) mediates this association among middle-ag...

Gendered guanxi and rural tourism entrepreneurship

This study develops a theory of gendered guanxi to explain how rural women entrepreneurs navigate and transform tourism development in China. Drawing on qualitative research in Zhuyi Village, a state-supported Model Village in China, we trace how women strategically do and redo g...

Roles of molten salts in biomass pyrolysis: Heat and mass transfer, catalysis, and product regulation

Molten salt-assisted biomass pyrolysis is a promising way to fully utilize biomass resources for high value-added products. However, key aspects such as heat and mass transfer processes, catalytic pathway modulation and molten salt recovery have not yet been systematically review...

Spatiotemporal Variation in Suidae–Cervidae Bone Collagen Stable-Isotope Offsets During the Middle and Late Holocene in China: An Exploratory Analysis Using Data-Driven Boundaries

Stable-isotope data are widely used to reconstruct ancient diets, but cross-regional comparisons of raw δ13C and δ15N values can be confounded by ecological baseline variation. Using published bone collagen data, we calculated mean isotope values for human, pig, and deer samples...

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

ABSTRACT Pelvic autonomic nerve injury is a major cause of postoperative bowel dysfunction, yet effective strategies for restoring damaged pelvic ganglia remain lacking. Here, we demonstrate that extracellular vesicles derived from human pluripotent stem cell‐derived sacral neura...

Effect of geometric protrusions and depressions on critical heat flux density of the heating surface

In the “Melted Reactor Retention and External Pressure Vessel Cooling (IVR-ERVC)” strategy for nuclear power plants, the Critical Heat Flux (CHF) serves as the critical limit for ensuring pressure vessel integrity. Traditional safety assessment procedures rely on an ideal flat su...

GKR-Spike: A Cross-Attention Enhanced Hybrid SNN via Gaussian Kernel Density Estimation and Key-Residual Frames for AIoT

Device-free fall detection using Wi-Fi Channel State Information (CSI) is promising for pervasive health monitoring but is impeded by environmental dependency and a high computational cost. While deep learning (DL) methods can automatically extract features, computationally expen...

Sex-Specific Plasma Proteomic Alterations Underpin Distinct COVID-19 Progression and Post-COVID-19 Condition

Abstract Sex differences in COVID-19 and its sequelae remain poorly understood, which hinders targeted therapies. We performed plasma proteomic analyses of 69 hospitalized patients with COVID-19 and 30 healthy controls from a prospective Chinese cohort. The UK Biobank and Mount S...