Sun Yat-sen University

Risk Prediction Models and Predictors of Low Anterior Resection Syndrome in Patients with Rectal Cancer: A Systematic Review and Meta-Analysis

Objectives Identifying patients at high risk of low anterior resection syndrome (LARS) after rectal cancer surgery may facilitate early management and improve postoperative quality of life. Several LARS prediction models have been developed, but their predictive performance and m...

Data-driven modeling of Galactic diffuse emission with multi-wavelength observations

Abstract We present a data-driven investigation of Galactic diffuse emission. Using multi-frequency Planck maps (30–857 GHz), we construct a non-linear mapping between microwave-to-far-infrared and gamma-ray intensity through supervised machine learning. Our models achieve high p...

Knowledge and attitudes about artificial intelligence and its applications among Chinese endodontic practitioners: a cross - sectional survey

Artificial intelligence (AI) has been increasingly applied in dentistry, including cariology and endodontics. However, evidence remains limited regarding endodontic practitioners’ AI literacy, perceptions, clinical usage, and barriers to AI integration. This study aimed to invest...

De Novo Discovery of Cysteine-Targeted Reversible Covalent Cyclic Peptides with Prolonged Residence Time via Phage Display

Abstract Reversible covalent targeting of cysteine residues offers a powerful strategy for generating potent and tunable ligands, but designing electrophiles with balanced reactivity, stability, and reversible binding remains challenging. Here, we systematically optimized reversi...

Haploidentical hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for severe aplastic anemia patients aged 40–65: a multicenter retrospective study

Abstract Immunosuppressive therapy (IST) plus eltrombopag (EPAG) (IST+EPAG) is the preferred first-line treatment for severe aplastic anemia (SAA) patients over 40 years. However, direct comparison between IST+EPAG and upfront haploidentical hematopoietic stem cell transplantatio...

Tumor specific cytokine pattern explored in renal cell carcinoma

Renal cell carcinoma (RCC) is a common urological malignancy, yet the cytokine landscape of the tumor microenvironment, especially in early-stage tumors, remains poorly defined. Using antibody arrays, 174 tumor-related cytokines were measured in 20 sets of normal, para-cancerous,...

Circulating RANKL is required for glucose homeostasis during pregnancy

Gestational diabetes mellitus (GDM) poses a significant health burden on women worldwide, necessitating the search for predictive, diagnostic and therapeutic approaches. Increasing evidence suggests that the receptor activator of NF-κB ligand (RANKL) is closely associated with GD...

The Piezo1/Ca²⁺/NOTCH2 axis mediates matrix stiffness-induced osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells

Human bone marrow-derived mesenchymal stem cells (hMSCs) are key seed cells with multi‑lineage differentiation potential, and their osteogenic differentiation capacity forms the basis of bone regeneration. Extracellular matrix stiffness acts as a potent biophysical cue directing...

Thianthrenium Salt-Mediated Site-Selective Coupling of Arenes with Enynones

Abstract Herein, we report a palladium-catalyzed, diazo-free, regioselective carbene coupling reaction of unactivated arenes with furyl carbenes, which are readily generated in situ from enynones, serving as safe and practical surrogates for traditional carbene sources. In this t...

Selective Denitrificative Fluorination and Desulfurative Fluorination Controlled by AgF/AgF2

Abstract The development of novel N-fluoroalkylated phosphoramidates will enrich the toolbox of organophosphorus chemistry. Here, we report the synthesis of [19F]/[18F] phosphoramidofluoridates and N-CF3 phosphoramidates via two controllable fluorinations of phenyl phosphorylcarb...

Rigid-Flexible Coupling Pore Engineering in Covalent Organic Frameworks Enables the Selective Identification of Nucleotide Analogues

Abstract Covalent organic frameworks (COFs) offer programmable pore architectures and tunable host–guest interactions, yet their rigid channels limit the selective recognition of structurally similar biomolecules─a longstanding challenge in sensor design. Inspired by enzymatic po...

The Multidimensional Metaphorical Network and Ecological Philosophy in Emily Dickinson’s Garden Poetry

This thesis examines Emily Dickinson’s garden poetry by establishing the epistemological commensurability between cognitive poetics and ecopoetics. Grounded in embodied horticultural practice, by applying Conceptual Metaphor Theory (CMT) and Conceptual Blending Theory (CBT), this...

Spatial and single-nucleus transcriptomics reveal the complexity of genomic imprinting in maize

Genomic imprinting is a classic epigenetic phenomenon first discovered in maize, which occurs predominantly in the triploid endosperm and is thought to mediate parental influences on seed development. Previous studies based on bulk RNA sequencing of manually dissected endosperm h...

Dynamics at Infinity and on Invariant Algebraic Surfaces of a Generalized Lorenz-Type System

In this paper, we investigate the global dynamics of a generalized Lorenz-type system. We determine the phase portrait at infinity under the Poincaré compactification in [Formula: see text]. Moreover, we analyze the dynamics restricted to invariant algebraic surfaces and provide...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Metagenomic analysis of developmental-category-associated fungal communities in the gut contents of Achatina fulica, an intermediate host of Angiostrongylus cantonensis

The invasive giant African snail ( Achatina fulica ) poses serious agricultural and ecological threats and serves as an important intermediate host of the zoonotic parasite Angiostrongylus cantonensis , which causes human eosinophilic meningitis. While its gut bacterial microbiom...

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21 st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signali...

Bone‐Targeted Engineered Exosomes Delivering Betaine Alleviate Osteoporosis via Autophagy‐Driven Osteogenesis

Dysregulated bone remodeling, attenuated endogenous osteogenic capacity, and the lack of bone-targeting capability in therapeutics constitute the core challenges in current clinical interventions for osteoporosis. In this study, a hybrid nanodelivery system integrating betaine-lo...

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

ABSTRACT Resistance to second‐generation antiandrogens poses a major therapeutic challenge in castration‐resistant prostate cancer (CRPC). While ferroptosis evasion has been implicated in treatment failure, the key molecular determinants driving this evasive process are poorly un...

Anion‐Doped Manganese Oxides Enabling Relay Catalysis for Aerobic Alcohol Ammoxidation

ABSTRACT The development of noble‐metal‐free heterogeneous catalysts for room‐temperature aerobic ammoxidation of alcohols to nitriles represents an enduring challenge, primarily hampered by unselective lattice‐oxygen over‐oxidation via the classical Mars–van Krevelen (MvK) pathw...