Sun Yat-sen University

Toeplitz-structured deep unfolding network for TomoSAR 3-D reconstruction

Urban area 3-D imaging is a key application of synthetic aperture radar (SAR). Classical compressive sensing-based tomographic SAR methods rely on iterative optimization, which is computationally expensive and sensitive to hyperparameter tuning, limiting its scalability for large...

Meningeal lymphatics orchestrate vertebral neutrophils via a Hex1Cer-NETs axis to promote autoimmune neuroinflammation

Abstract Meningeal enhancement is observed on cranial and spinal magnetic resonance image in a subset of patients with multiple sclerosis (MS) and is associated with a higher risk of future disease progression, however, the underlying mechanisms by which it promotes such progress...

On the Convergence of JPEG Multiple Compression for Digital Forensics

Convergence means that the limit of the sequence will tend to a certain value. In some forensic scenarios, if the same manipulation is repeatedly performed on an image, the resulting image sequence tends to converge. Credible forensics can be achieved by utilizing this convergenc...

TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with limited molecular targets. This study aimed to identify candidate genes involved in ICC progression and to examine the functional role of PBK. Integrated bioinformatics analysis was performed on TCGA-CHOL data...

A Robust Mitochondria‐Targeted Photosensitizer Synergizes With Cisplatin Chemotherapy for Enhanced Antitumor Immunity

ABSTRACT Chemotherapy remains a major strategy for cancer treatment, with cisplatin widely used as a first‐line agent for diverse malignancies. Although cisplatin efficiently induces tumor cell death through DNA damage, its therapeutic efficacy is often limited by the development...

Cascading effect of early sensory differences on subsequent autistic traits in infants later diagnosed with autism: a prospective cohort study

Sensory differences constitute core diagnostic features of autism. The cascading effect model posits that early sensory differences may be prospectively associated with subsequent autistic traits, whereas empirical evidence in infancy remains scarce. This study aims to characteri...

Neighboring Fe-Cr electronic coupling simultaneously promotes intrinsic activity and suppresses Fe-induced degradation for oxygen reduction electrocatalysis

Fe-N-C catalysts are among the most promising platinum-group-metal-free electrocatalysts for the oxygen reduction reaction (ORR), yet their practical application is limited by the insufficient intrinsic activity of isolated Fe sites and Fe-induced degradation. Herein, a neighbori...

Proximal ProteomicsReveals Potential Regulators ofProgrammed Death-Ligand 1 in Human Cancer

Abstract Programmed death-ligand 1 (PD-L1) is a key mediator of tumor immune evasion, but the protein networks governing its post-translational regulation remain incompletely understood. Here, we used PhastID-based proximity labeling to map the PD-L1 proximal proteome and integra...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

ImbibitionTheory and Design for Multiscale MicropillarRandom Arrays

Abstract Efficient liquid transport in micrometer-scale confined spaces is crucial for phase-change thermal management systems, like heat pipes (HPs). While multiscale micropillar random arrays (MMRAs) demonstrate enhanced imbibition performance, their structural randomness has h...

2-methylbutanal remodels arachidonic acid metabolism and antitumor immunity through ENO1 in colorectal cancer

Active aldehydes are increasingly recognized as bioactive metabolites, but their roles in tumor immune regulation remain poorly defined. In colorectal cancer (CRC), prostaglandin metabolism contributes to immune suppression, whereas its upstream metabolic regulators are incomplet...

Gamma-Irradiation-EnhancedReduction of 99Tc(VII) and Re(VII) by Natural Pyrite

Abstract Reductive immobilization of 99Tc(VII) to sparingly soluble TcO2-type phases is a key process limiting 99Tc transport in the environment. However, the reactivity of natural pyrite toward 99Tc(VII) under conditions relevant to nuclear waste repositories remains poorly unde...

AOPQ-Net Acoustic–Optical Proposal Query Network for Underwater Multimodal Object Detection

Optical cameras and imaging sonars are widely used sensors in autonomous underwater vehicles. However, their different imaging mechanisms introduce substantial cross-modal discrepancies in the acquired data. In addition, underwater optical images are often degraded by low illumin...

Interaction-AwareGraph Learning for State-of-HealthEstimation of Sodium-Ion Batteries

Abstract Accurate state-of-health (SOH) estimation is critical to the reliable operation and large-scale deployment of sodium-ion batteries (SIBs). However, the complex and nonstationary degradation behavior of SIBs under different charging protocols pose a major challenge to ach...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

ABHD11-Mediated mtDNA Transcription Restored Mitochondrial Function to Attenuate Cardiomyocyte Ferroptosis After Myocardial Infarction

BACKGROUND: Cardiomyocytes exhibit marked susceptibility to ferroptosis after myocardial infarction (MI), rendering ferroptosis inhibition a promising therapeutic strategy to mitigate ischemic myocardial injury. Although mitochondrial dysfunction is recognized as a core driver of...

Cavity-Size-Dependent Recognition of Naphthalene Derivatives by 3,3′-Bipyridinium Tetracationic Cyclophanes

The recognition behavior of tetracationic cyclophanes is strongly influenced by the geometric match between the host cavity and aromatic guests. Herein, we compare two 3,3′-bipyridinium-based tetracationic cyclophanes, BPy-Box⁴⁺ and NBox⁴⁺, toward a series of naphthalene derivati...

A triboelectric nanogenerator sensor-based capture, positioning and release mechanism (CPRM) for test mass in TianQin Gravitational Wave detection Project

Space-based gravitational wave (GW) detection offers a powerful platform for observing millihertz GW signals and probing extreme astrophysical phenomena. As an important part for GW detection, monitoring key state during test-mass (TM) capture, positioning, and release is essenti...

Crystalline Lens Tilts Less With Higher Myopia in Children With Limited Age-Related Effect

Purpose: To evaluate tilted crystalline lens morphology in children across different orientations and their correlations with age and spherical equivalent (SE). Methods: This cross-sectional study encompassed 966 eyes of 493 children (5-15 years; SE, -6.00 to +3.00 diopters [D])....

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...