Sun Yat-sen University

CoNewsReader: Supporting Comprehensive Understanding and Raising Critical Thoughts on Social Media News Through Comments

Critical news reading (CNR), which requires grasping the holistic ideas of and raising critical thoughts on the news, is beneficial yet challenging for general people who usually get information on daily social media. Comments under the news can aid CNR by providing complementary...

Applications of the multi-process action control framework in physical activity promotion: a scoping review

The “intention-behavior gap” represents a core bottleneck in the failure of health behavior interventions, with traditional theories offering insufficient explanations for the dynamic mechanisms from intention formation to behavior maintenance. The Multi-Process Action Control (M...

Perirenal fat thickness was associated with reduced estimated glomerular filtration rate in the hospital-based population: a mediation analysis

It is unclear how perirenal fat thickness (PrFT) and impaired renal function are related, particularly in patients with metabolic risk factors. A hospital-based cohort of individuals was examined to determine whether perirenal fat thickness, as measured by magnetic resonance imag...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

Triglyceride glucose‑derived indices combined with high‑sensitivity C‑reactive protein for predicting glycemic progression and regression in prediabetes: findings from a prospective national cohort study based on baseline and cumulative change analyses

Recent studies have identified triglyceride-glucose (TyG)‑derived indices as important novel predictors of progression from prediabetes to diabetes and regression to normoglycemia, with chronic inflammatory burden serving as a key mediator in this association. Building on these o...

Integrated analysis identifies a platinum resistance-related prognostic signature for overall survival in hepatocellular carcinoma

This study aimed to identify prognostically relevant genes from a platinum resistance-related pathway and to develop a concise signature for predicting overall survival (OS) in patients with hepatocellular carcinoma (HCC). We conducted an integrated bioinformatics analysis using...

Coronary plaque phenotypes, inflammation and cardiovascular prognosis in metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) correlates with cardiovascular events. We sought to assess the association of coronary computed tomographic angiography (CCTA)-detected high-risk plaque characteristics (HRPC) and coronary inflammation with MASLD an...

Genomic divergence and phenotypic heterogeneity of Legionella longbeachae reveal a putative novel proinflammatory serogroup with genome reduction and mobilome expansion

ABSTRACT Legionella longbeachae is an emerging respiratory pathogen primarily found in soil environments, yet its genomic architecture and evolutionary strategies remain poorly characterized. Here, through pan-genomic and functional analysis of 242 L. longbeachae isolates, we rev...

Involvement of the MAPK8-Caspase‑3 Apoptotic Pathway in Arecoline‑Associated Periodontitis

Aims Arecoline, a major betel nut-derived alkaloid associated with betel nut chewing, is linked to increased periodontitis severity, but the molecular mechanisms by which it contributes to periodontitis progression remain unclear. Materials and methods Arecoline- and periodontiti...

Large Rabi Splitting Driven by Plasmon‐Enhanced Hybrid Anapole States in Si–Au–WSe 2 Heterostructures

ABSTRACT Exciton–polaritons arising from strong light–matter coupling are key enablers of quantum coherent phenomena, whereas large Rabi splitting is critical for ensuring their robustness and stability. However, existing microcavity photonic modes rarely combine low radiative di...

Effectiveness of anti-TNF therapy after prior ustekinumab exposure in Crohn’s disease: A propensity-weighted cohort study

Abstract Background As ustekinumab is increasingly used earlier in Crohn’s disease (CD), evidence regarding the effectiveness of subsequent anti-tumor necrosis factor (TNF) therapy remains limited. We compared anti-TNF outcomes after prior ustekinumab exposure with first-line ant...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Integrative phylogenomics, polyphasic taxonomy, and metagenomics expand the characterized taxonomic diversity of Thermoleophilia

Abstract The class Thermoleophilia represents a deep‐branching lineage within the phylum Actinomycetota , and yet, its taxonomic diversity remains incompletely resolved due to the limited availability of cultured representatives and uneven integration of genome‐resolved diversity...

Programmable Te/MoTe 2 van der Waals Heterojunction for Image Preprocessing and Dynamic Recognition

ABSTRACT Van der Waals materials and their heterostructures offer strong gate tunability, enabling multilevel and polarity‐switchable photoresponse states in programmable photodetectors for in‐sensor encoding and computing. However, current gate‐programmable photodetectors often...

Postoperative radiotherapy for limited-stage high-grade neuroendocrine cervical carcinoma: a retrospective multi-center study from two Chinese institutions

Current treatment guidelines rely on limited retrospective data due to the rarity of high-grade neuroendocrine cervical carcinoma, which lacks consensus on the efficacy of postoperative radiotherapy. To facilitate decision-making support for individual patients, a recursive parti...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...

Decoding cell division history and lineage-resolved phenotypic patterns from single-cell barcode and transcriptomic data

The cell division tree encodes how proliferation and differentiation generate cellular diversity during multicellular development. Advances in single-cell RNA sequencing and CRISPR-based lineage tracing have enabled retrospective reconstruction of these histories at single-cell r...

Renal-Clearable Fluorogenic Nanoprobes for Molecular Imaging of Hepatic Drug-Metabolizing Cytochrome P450 2C19 Enzyme

Abstract Despite the fact that cytochrome P450 2C19 (CYP2C19) is an essential xenobiotic-metabolizing enzyme in many drug metabolisms, the real-time and dynamic monitoring of its activity remains challenging due to the lack of highly specific activity-based probes with translatio...

Remimazolam versus sevoflurane for maintenance of anesthesia and postoperative nausea and vomiting in laparoscopic gynecologic oncology surgery: a randomized controlled trial

Postoperative nausea and vomiting (PONV) remains a frequent complication following laparoscopic gynecologic surgery, particularly in female patients with multiple established risk factors receiving volatile anesthetics. Remimazolam, a short-acting benzodiazepine, is an alternativ...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...