Sun Yat-sen University

NonlinearSynergistic Coupling of Poisson Deformationand Crack Engineering Enables Linear Mechanosensing up to 4 MPa

Abstract Reliable and accurate physiological mechanosensing requires tactile sensors that maintain linearity across ultrawide ranges, yet most reported devices saturate below 500 kPa due to strain hardening and deformation saturation of elastic microstructures. Balancing this lon...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Longitudinal MRI-based Delta-Habitat model for predicting pathological complete response to neoadjuvant chemoimmunotherapy in head and neck squamous cell carcinoma

To develop and validate a machine learning model integrating habitat imaging features before and after neoadjuvant chemoimmunotherapy (NACI) to predict pathological complete response (pCR) to NACI in head and neck squamous cell carcinoma (HNSCC). A multicenter retrospective study...

Elevated aerosol layers within the daytime mixed layer over ecologically sensitive areas of northwest China: diurnal variation, formation mechanisms and regional effects

Abstract. The cyclic processes of aerosol evolution have a profound impact on regional climate, water resources and ecosystems. However, studies on diurnal variations of aerosol vertical distribution in typical ecologically sensitive areas remain scarce due to limited availabilit...

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy is largely ineffective in most solid tumors, partially because of inadequate intratumoral trafficking. Bridging therapy, administered between leukapheresis and CAR‐T cell infusion, offers a distinct opportunity to control th...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

MemTrax as a scalable digital triage tool for mild cognitive impairment screening: primary validation in Alzheimer’s disease and exploratory analysis in Parkinson’s disease

Alzheimer’s disease (AD) and Parkinson’s disease (PD) pose escalating global health challenges, with early detection of mild cognitive impairment (MCI) being critical for timely intervention. The 2023 Delphi consensus highlights the need for scalable tools suitable for primary ca...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Efficacy of anti-PD-1/PD-L1 plus chemotherapy in treatment-naïve advanced HER2-negative gastric adenocarcinoma among different PD-L1 intervals: an updated meta-analysis and reconstructed individual patient-level data analysis

Abstract Background Chemo-immunotherapy (CIT) has become the frontline therapy for advanced human epidermal growth factor receptor 2 (HER2)-negative gastric or gastro-esophageal junction adenocarcinoma (GEAC). However, emerging evidence suggests that clinical benefit is primarily...

A multi-class gastric biopsy artificial intelligence model developed from whole slide histopathological images

Pathological diagnosis of biopsies remains the gold standard for gastric diseases such as gastric carcinoma (GC), but it suffers from clinical misdiagnosis and high workload. Accurately distinguishing early-stage GC (EGC) from advanced-stage GC (AGC) and preoperatively predicting...

A deep learning framework for amplitude generation of generic EMRIs

Abstract One of the main targets for space-borne gravitational wave detectors is the detection of Extreme Mass Ratio Inspiral (EMRIs). Data analysis of EMRIs requires waveform models that are both accurate and fast. The major challenge for the fast generation of such waveforms is...

Benchmarking RNA-seq with the Quartet and MAQC reference materials to establish best practices for accurate alternative splicing analysis

Previous limited characterization of short-read RNA-seq (srRNA-seq) accuracy in alternative splicing (AS) analysis due to methodological diversity and lack of reference standards, has left unclear how to achieve optimal performance—an issue increasingly critical with the rise of...

Discovery of a peripheral Myh11-expressing nucleus pulposus cell population demontrating therapeutic potential for disc degeneration

Continual turnover of nucleus pulposus (NP) cellularity is critical for maintaining intervertebral disc (IVD) homeostasis; however, the presence and identity of potential progenitor cells within the NP remain unclear. This study identifies NP cells expressing myosin heavy chain 1...

Drivers of flash flood frequency and intensity in the United States: a quantitative analysis of hydrometeorological interactions

Abstract. Inconsistent changes in precipitation and flooding have spurred investigations into the underlying mechanisms, yet the quantitative understanding of interactions between precipitation, temperature, and land cover in streamflow dynamics remains limited. We investigate st...

Oceanic Thermal and Storm Dynamic Controls on Precipitation Variability of Landfalling Typhoons in Zhejiang Province, China (2000–2025)

Landfalling typhoons frequently cause severe flooding and socioeconomic losses along the eastern coast of China, yet the relative influence of oceanic and storm-related factors on precipitation variability remains insufficiently understood. This study investigates the relationshi...

Roles of cerebrospinal fluid metabolites in neuromyelitis optica spectrum disorder: Insights from Mendelian randomization

Neuromyelitis optica spectrum disorder (NMOSD) is a rare multifocal inflammatory disease that primarily affects the optic nerve and spinal cord, leading to visual loss and paralysis. Although current research has identified numerous biomarker changes in the cerebrospinal fluid (C...

Optimized Molecular Nucleation Behaviors in Highly Efficient Organic Solar Cells Enabled by a Bezothiophene-Based Solid Additive

As the most critical component of organic solar cells (OSCs), the morphology of the active layer directly dictates the photovoltaic performance of the devices. Recent studies have demonstrated that tailoring the active layer morphology using solid additives is a facile and effect...

Preparation Method of Simulated Deep Sandstone Materials Based on Dual Equivalence of Principal Components and Mechanical Properties, and Quantitative Evaluation of Simulation Effectiveness

Intact deep sandstone cores are scarce, heterogeneous with poorly repeatable, limiting systematic laboratory studies of deep-rock mechanical behavior. This study selected dense sandstone recovered from 1050 m in the Pingdingshan mining area as the prototype system for the develop...

Prevalence and associations of biological rhythm disorders with depression and anxiety symptoms in Chinese adolescents: A multicenter study across seven provinces

Biological rhythm disruption is increasingly implicated in adolescent emotional ill-health. We conducted a multicenter cross-sectional survey of 9,498 senior high school students (15–18 years) from seven Chinese provinces. Depressive and anxiety symptoms were assessed with the Pa...

Targeted uterine artery infusion of bone marrow-derived mesenchymal stem cells for severe intrauterine adhesions: a randomized controlled trial with exploratory translational analyses

Severe intrauterine adhesions (IUA) represent a profound failure of endometrial regeneration, characterized by excessive fibrosis and vascular insufficiency. Mesenchymal stem cell-based therapies show regenerative potential, but clinical evidence is inconsistent, and optimal deli...