Sun Yat-sen University

The Oxidized Phospholipid PGPC Impairs Angiogenesis by Inhibiting Endothelial Autophagosomal–Lysosomal Fusion Through NPC1-Induced Syntaxin 17 Acetylation and Ubiquitination

BACKGROUND: Angiogenesis is essential for the recovery of ischemic hearts with coronary artery disease (CAD). PGPC (1-palmitoyl-2-glutamyl-sn-glycero-3-phosphocholine) is a major phospholipid oxidation product in atherosclerotic lesions. Autophagy participates in angiogenesis. Ho...

Poly(propylene carbonate- co -thioether- co -ether) Terpolymer and Its Application as a Solid-State Electrolyte

Abstract Sulfur-containing polymers, especially those with sulfur in the main chain, have attracted significant interest owing to their diverse structures and unique properties, making them promising candidates for solid-state electrolytes. However, their controllable synthesis i...

Dirac‐Point‐Assisted Topological Charge Exchange in Dual‐Wavelength BIC Vortex Microlasers

ABSTRACT On‐chip lasers that emit wavelength‐multiplexed structured light are important in integrated photonics. Bound states in the continuum (BICs) provide high‐quality resonances with radiation topology, enabling vortex lasing at multiple wavelengths. However, the topological...

Shared genetic architecture underlying cataract and cardiovascular disease: insights from multi-omics analyses

Abstract Cataract and cardiovascular disease (CVD) are prevalent age-related disorders with overlapping risk factors. While epidemiological associations are established, the shared genetic mechanisms underlying their comorbidity remain largely unexplored. We performed a comprehen...

The Dual-Ribozyme RNA Ladder and RNA-Calibrated ssDNA Marker System for Inexpensive RNA Size Standards

Abstract RNA size markers are essential for denaturing Urea-PAGE analysis, but commercial RNA ladders are expensive, available only in fixed size ranges, and require careful handling to prevent RNA degradation. Here, we developed a modular dual-ribozyme platform for preparing RNA...

Comparative corneal biomechanical characteristics in polypoidal choroidal vasculopathy and neovascular age-related macular degeneration analyzed by corvis ST: a cross-sectional study

To explore the differences in corneal biomechanical characteristics among patients with polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and healthy individuals. This cross-sectional study included patients with nAMD or PCV and healthy...

Moral and perceptual conflict processing are implemented by distinct brain activation and functional connectivity patterns

While humans resemble other primates in terms of motor and perceptual abilities, our behavior is uniquely characterized by morality—the ability to choose our actions based on specific ethical values. The evolutionary origins and neurobiological basis of moral behavior are debated...

Iterative Optimization of Photoactivatable BRD4 Degraders for Aging‐Amplified Immunotherapy in Patient‐Derived Lung Cancer Organoids

ABSTRACT Cancer remains a major global health threat. Targeted protein degradation (TPD) has revolutionized the modulation of protein function in therapeutic development. Nevertheless, the design of current TPD agents continues to face challenges, including hook effects and, more...

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

ABSTRACT Successful pregnancy requires dynamic extracellular matrix (ECM) remodeling at the maternal‐fetal interface, yet whether individual collagen subtypes actively regulate this process remains unknown. Here, collagen type XXIV alpha 1 chain (COL24A1), a uterine‐enriched fibr...

Halogen‐Bond Dimensionality Controls π–π Packing to Unlock Ultrahigh Second‐Harmonic Generation and Giant Birefringence

ABSTRACT Compact all‐solid‐state lasers require nonlinear optical crystals that combine strong second‐harmonic generation (SHG) with large birefringence, yet planar π ‐conjugated molecules often pack antiparallel, canceling their macroscopic second‐order response. Here, we break...

A linear-in-$q$ range of dimensions for the MDS conjecture over $\mathbb F_q$ in odd characteristic

Let $q$ be a power of an odd prime $p$. We prove the MDS conjecture over $\mathbb F_q$ in every dimension $k$ satisfying$$ 2\leqslant k\leqslant B(p,q) \quad\text{or}\quad q+2-B(p,q)\leqslant k\leqslant q, \qquad B(p,q)=\left\lfloor\frac{(p-2)q+6p-10}{2p-3}\right\rfloor.$$For fix...

A hybrid framework combining enhanced fields and consistent spatial features for stroke lesion segmentation in MR images

Stroke lesion segmentation plays a critical role in clinical diagnosis, prognosis and rehabilitation treatment. However, this task remains highly challenging due to inter-subject differences, shape variations, noise and artifacts in MR images, which hinder the accurate extraction...

A linear-in-$q$ range of dimensions for the MDS conjecture over $\mathbb F_q$ in odd characteristic

Let $q$ be a power of an odd prime $p$. We prove the MDS conjecture over $\mathbb F_q$ in every dimension $k$ satisfying$$ 2\leqslant k\leqslant B(p,q) \quad\text{or}\quad q+2-B(p,q)\leqslant k\leqslant q, \qquad B(p,q)=\left\lfloor\frac{(p-2)q+6p-10}{2p-3}\right\rfloor.$$For fix...

LayerToFair: An Efficient Post-processing Framework for Layer-aware Fairness Repair of Deep Neural Networks

DNNs are increasingly deployed in high-stakes information systems, where fairness is a critical requirement. Existing post-processing methods can repair unfairness without retraining or accessing original data, but they often treat all layers indiscriminately, resulting in high c...

mRNA-LNP vaccines targeting conserved virulence factors elicit protective immunity against lethal Legionella pneumophila infection

Legionnaires’ disease (LD), caused by the intracellular pathogen Legionella pneumophila , imposes a substantial global health burden, yet no vaccine has been clinically approved. Here, we develop mRNA-LNP vaccines encoding conserved virulence factors Pal, PilE, and FlaA. In BALB/...

Can Non‐Orthogonal Bases Form Stable Skyrmionic Beams?

ABSTRACT Skyrmions, topologically stable spin textures, have recently garnered significant attention in optics, promising robust high‐density information transmission and nontrivial light‐matter interaction. Optical skyrmionic beams have generally been considered to require the s...

Single-nucleus transcriptomics reveals an early-relapse-associated epithelial–myeloid–T cell niche in advanced high-grade serous ovarian cancer

Early relapse remains a major clinical challenge in advanced HGSOC, but the tumor microenvironmental features associated with relapse timing remain poorly defined. Here, we performed snRNA-seq on treatment-naive tumors from patients with advanced HGSOC, including STDFS ( n = 4) a...

Chest wall tissue microsporidiosis associated with metagenomic next-generation sequencing detection of Encephalitozoon cuniculi: a case report

Encephalitozoon cuniculi is an obligate intracellular microsporidian that typically causes clinically apparent disease in immunocompromised hosts, whereas symptomatic infection in individuals without recognized immunodeficiency is uncommon. We report a 57-year-old man without kno...

Temperature-dependent phage-bacterium coexistence strategy mediates the intestinal microbial community diversity in shrimp

The diversity of intestinal bacterial communities is closely associated with host health. Phage-bacterium interactions are key determinants of this diversity, and temperature represents a critical environmental factor influencing these interactions. At elevated temperatures, path...

Three-decade trends in nonalcoholic fatty liver disease across 204 countries and territories

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading chronic liver disease globally, driven by the rising incidence of obesity, type 2 diabetes, and metabolic syndrome. Despite the increasing burden, most studies focus on prevalence rather than incidence, leaving a g...