Northwestern University

Translating etiological effect measures into medical test evaluation metrics

Abstract Traditional metrics for medical test evaluation (TE) and etiological evaluation (EE) are often analyzed within separate frameworks. We review these metrics, including recommendations to use less frequently used TE metrics. We propose a novel framework for TE by drawing f...

Alkoxyethyl Acetate Electrolytes for High‐Voltage Lithium Metal Batteries

High-energy-density lithium metal batteries (LMBs) require electrolytes that can simultaneously support stable lithium metal anodes and high-voltage cathodes such as NMC811 operated up to 4.5 V. Here, a molecular engineering strategy is introduced in which a carbonyl group and a...

Percutaneous peripheral nerve stimulation as an ancillary treatment following nerve repair surgery

Abstract Background Neuropathic pain after peripheral nerve injury severely degrades quality of life. Peripheral nerve stimulation (PN‐Stim) is cleared by the U.S, Food and Drug Administration for the treatment of acute and chronic pain. This broad indication supports its potenti...

Response to Comment on Baseline Haemoglobin Predicts Oncologic Outcomes in Intrahepatic Cholangiocarcinoma Treated With Yttrium‐90 Radioembolisation: A Retrospective Cohort Study of 136 Patients

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

Associations between smooth pursuit, predictive pursuit, anomalous self-experiences, and psychotic-like experiences

Abstract Oculomotor dysfunction is well-documented in the psychosis spectrum, particularly deficits in smooth pursuit eye movements. These disruptions are thought to serve as endophenotypic markers of psychosis vulnerability and more recent work has linked oculomotor dysfunction...

Integrating HiTOP and clinical staging: A developmental framework for multidimensional psychiatric assessment

Abstract Precise assessment and classification of psychopathology are essential components of precision psychiatry. The transdiagnostic clinical staging model holds tremendous promise to advance classification of psychopathology across the lifespan, but it is currently limited in...

Vascular Imaging Features and Time-Specific Recurrence Risk After Craniocervical Artery Dissection

Background and ObjectivesCraniocervical artery dissection (CCAD) is a major cause of stroke in young adults, yet its recurrence risk remains poorly defined because of delayed enrollment in prior research. We aimed to determine the temporal distribution of recurrent ischemic strok...

Performance and Symptom Validity Testing: Terminology, Conceptualization, Practice Standards, and Future Directions

Abstract Purpose of Review This commentary summarizes terminology and practice standards for assessing the validity of test scores obtained during neuropsychological evaluations. It also highlights conceptual gaps and emerging directions for improving validity assessment. Recent...

A compact, wireless fluorimeter system for continuous, real-time monitoring of tissue perfusion via in vivo fluorescence signals

In vivo fluorescence signals provide physiological and pathological insights for the interpretation of biological states associated with anatomical abnormalities or disease. Conventional methods for measuring fluorescence signals rely on bulky, costly instrumentation for imaging...

The primary premium: Why legislators are incentivized to side with primary voters over general election voters

How are legislators incentivized to behave when their primary and general electorates disagree about an issue? We argue that primary electorates are generally more unified in their issue preferences and more sensitive to roll-call positions than general electorates, incentivizing...

Consensus-Based Definitions for Vocal Biomarkers: The International VOCAL Initiative.

Introduction: Voice-based health technologies are growing rapidly, but they lack standardized terminology, which hinders interdisciplinary collaboration, research quality, and clinical translation. The objective of this work was to develop universally accepted definitions in the...

International variation in neuropsychological test use practices: Implications for test adaptation and fair assessment

Neuropsychological test selection varies substantially across countries and languages, yet which instruments clinicians use internationally remains poorly documented. Using a survey of International Neuropsychological Society members (INSConnect, 2023), we examined instrument end...

Disparities in Blood Pressure Measurement

Abstract Purpose of review We aimed to examine how inaccuracies and inequities in blood pressure (BP) measurement across office, ambulatory, home, and emerging cuffless modalities contribute to disparities in hypertension diagnosis and control, and to identify strategies to impro...

Comparison of Visual Feedback Conditions While Learning a Redundant Novel Visuomotor Task

Human movement relies on coordinating multiple degrees of freedom (DOFs) converging onto fewer DOFs of functional goals. We compared two forms of visual feedback as participants learned a novel motor task: using 18-DOF finger movements to control a 3-joint kinematic chain, ultima...

A Polynomial Improvement for the Odd Cycle–Complete Ramsey Numbers

Abstract We give a polynomial improvement to the cycle-complete Ramsey numbers $$\begin{aligned} r(C_{\ell },K_k) \geqslant k^{1+\frac{1}{\ell -2} + \varepsilon _{\ell } + o(1)}, \end{aligned}$$ r ( C ℓ , K k ) ⩾ k 1 + 1 ℓ - 2 + ε ℓ + o ( 1 ) , for all fixed odd $$\ell > 7$$ ℓ >...

Outer Retinal Volume on Macular OCT Predicts Two-Year Diabetic Retinopathy Progression

Purpose: To evaluate whether baseline retinal volume from macular optical coherence tomography (OCT) is associated with diabetic retinopathy (DR) progression over two years. Methods: In this longitudinal observational study, 190 eyes from 121 patients, across the DR severity spec...

Identifying Essential Topics for an Introductory Training Course on Eating Disorders:

There are no widely agreed-upon guidelines in the United States for topics that should be included in introductory training courses for identifying and treating eating disorders (EDs). The purpose of this study was to conduct a Delphi survey, bringing together a diverse group of...

Integrated Mental Health Care for Perinatal Anxiety and Depression in the United States: A Systematic Review

OBJECTIVE: The ongoing maternal mental health crisis highlights the urgent need to improve access to integrated behavioral health care within medical settings for perinatal individuals. This review aimed to synthesize the current evidence on integrated models of care in the Unite...

Disorder-promoted stability

Previous studies of network dynamics have suggested that heterogeneity among nodes inhibits stability, which is at odds with the ubiquity of inherently heterogeneous natural and engineered systems. Here, we show that this conclusion arises from model reductions introduced for mat...

Nutritional Deficiencies, Complications, and Nutrition Therapy/Counseling in Pediatric Patients Using GLP-1 Receptor Agonists

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used to treat childhood obesity, prediabetes, and type 2 diabetes. We examined nutritional deficiency incidence and nutrition therapy/counseling (NT/C) utilization among pediatric GLP-1RA users. Met...