Northwestern University

Examining smartphone-assessed executive function metrics and intrinsic resting-state functional connectivity in depression

<title>Abstract</title> Major Depressive Disorder (MDD) is a common and costly mental health condition that is often associated with deficits in executive function. Smartphone applications (“apps”) have emerged as promising methods for assessing mental health-related outcomes in...

The Role of Dopaminergic Agonists in Geographic Atrophy: Converging Evidence From Clinical and Experimental Data

Purpose: Levodopa (L-DOPA) is an emerging drug repurposing candidate for age-related macular degeneration (AMD). Basic and clinical studies identify a potential role for L-DOPA to prevent and treat neovascular AMD. However, only one prior study has been performed in geographic at...

Accessible Complexity Bounds for Restarted PDHG on Linear Programs with a Unique Optimizer

The restarted primal-dual hybrid gradient method (rPDHG) has recently emerged as an important tool for solving large-scale linear programs (LPs). For LPs with unique optima, we present an iteration bound of [Formula: see text], where [Formula: see text] is the target tolerance, [...

The blood system in Ukraine: Experience in martial law conditions

BACKGROUND/CASE STUDIES: Efficient blood and blood components supply is key to the stable operation of a health care system, especially to a civilian population and military under martial law. The blood system is an important component of a state's defense capability and national...

Cranio-orbital craniotomy via an eyebrow incision for resection of anterior clinoid and tuberculum sella meningiomas

Abstract Background Anterior clinoid meningiomas (ACM) and tuberculum sella meningiomas (TSM) are anterior skull base tumors that commonly cause visual deterioration. The supraorbital keyhole approach may be used to resect these tumors but is limited by restricted intraoperative...

Four Lenses Toward Principle-Based Understanding of Granular Segregation in Dense Flows: Particle, Continuum, Statistical, and Conceptual Approaches

Abstract This review examines the development of concepts and models describing the spontaneous spatial separation—segregation—of dense flowing granular mixtures. Although particle-scale interactions are largely understood and modern discrete element methods can resolve system dy...

Cardiac Implantable Electronic Device Infection: Nationwide Trends in Extraction Utilization and In‐Hospital Outcomes

INTRODUCTION: Contemporary, real-world adherence to guideline-directed transvenous cardiac implantable electronic device (CIED) extraction for patients with CIED infections in the US remains incompletely characterized. As such, we sought to evaluate national trends in CIED extrac...

Gold‐Stabilized Copper Enables Anodic Hydrogen Evolution for Ultralow‐Voltage CO‐to‐Ethylene Electrolysis

ABSTRACT Electrochemical upgrading from CO 2 and CO to ethylene has typically been coupled with the oxygen evolution reaction (OER), whose high standard reduction potential leads to full‐cell voltages above 2.2 V at 200 mA/cm 2 . Here we explored an alternative anodic reaction, w...

Association between clinician team structure and continuous pulse oximetry overuse among infants hospitalized with bronchiolitis: An Eliminating Monitor Overuse Trial substudy

Abstract Continuous pulse oximetry (cSpO 2 ) monitoring for hospitalized children with bronchiolitis not requiring supplemental oxygen is an established form of medical overuse. We examined whether clinician team structure influences cSpO 2 overuse. In this secondary analysis of...

The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation

Abstract N-acetyltransferase 10 (NAT10) is a multifunctional enzyme that harbors RNA acetyltransferase and RNA helicase domains and has emerged as a therapeutic vulnerability in solid and hematological malignancies. By coupling Proteolysis Targeting Chimera-mediated degradation o...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Bridging Practice and Publication: Reexamining Quality Improvement in Pediatric Scholarship

Quality improvement (QI) publication rates in pediatrics surged through the early 21st century yet have noticeably plateaued since that time, a paradoxical shift given the volume of ongoing improvement work across pediatric health systems. We propose that the gap lies not in the...

Exploration of visual analogue scale versions with the EQ-HWB-9 to measure health, social care, and carer-related quality of life: a VASt landscape

Abstract Purpose Visual analog scales (VAS) serve as brief, informative patient reported outcome measures. The EQ VAS is an important component of EQ-5D instruments but is not currently included in the EQ-HWB-9. This study qualitatively assessed perceptions of alternative VAS con...

HeartMate 3 in Pediatric and Complex Populations: Physiologic Rationale, Patient Selection, and Management Strategies

The HeartMate 3 (HM3) left ventricular assist device (LVAD), initially designed for adults, is increasingly utilized in children, small adults, and those with congenital heart disease (CHD), necessitating expanded knowledge and collaborative efforts. This review highlights key ph...

The Financial Burden of Amyotrophic Lateral Sclerosis Diagnosis: Estimating Costs of Unnecessary Procedural Interventions and Exclusionary Testing

Background: People living with amyotrophic lateral sclerosis (ALS) experience diagnostic delays, involving multiple visits to neurologists and non-neurologist specialists. During this process, patients may be misdiagnosed and undergo unnecessary procedures. Additionally, ALS diag...

Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease

Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or ATP2A2 -nEDD), an autosomal domina...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Teaching the Halstead Category Test: A survey of post-doctoral fellowships in adult clinical neuropsychology

The Halstead Category Test (HCT) is considered among the most sensitive measures for detecting global neurological impairment. Although its ability to localize neurological dysfunction or to assess executive function has been questioned, its demonstrated diagnostic sensitivity to...

Within-Person Sweat Chloride Variability in People with Cystic Fibrosis Measured via Wearable Microfluidic Sticker

Melissa H Ross, Thaddeus Cybulski, Rachel S Nelson, Roozbeh Ghaffari, John A Rogers, A J Aranyosi, Garett J Griffith, Daniel M Corcos, Manu Jain; Within-Pe

LGBTQ+ Youth Sexual Orientation and Gender Identity Support in Schools

Abstract LGBTQ+ youth continue to report significant challenges to their wellbeing in schools (e.g., bullying, lack of representation in staff and curricula, and discrimination). The current study employed a large, diverse sample of LGBTQ+ youth to explore the types of support th...